Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and/or from intraosseous locations within one or more vertebral bodies. For example, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

An energy radiation treatment method comprises: administering a medicinal agent to an affected part; performing energy radiation with a predetermined energy on the affected part; and confirming therapeutic effects by the energy radiation on the affected part, wherein in the administering, a determination based on at least one ultrasound image based on ultrasound waves reflected from the affected part is performed.

A hand piece for delivering energy from a laser to a target through a fiber tip includes an elongated handle having a proximal end and a distal end. An axial bore traverses the handle along a longitudinal axis thereof. A fiber tip holding mechanism is fixed within the axial bore of the handle and includes a forward section fixed with the handle, a spring, and a rear section that includes a hollow collet projecting forward therefrom that traverses the spring and the forward section. The forward section is slidable rearward towards the rear section to compress the spring in a rear position. The spring urges the forward section forward into a forward position. A chuck is fixed with the forward end of the fiber tip holding mechanism and includes a tapered sleeve and two or more oppositely tapered jaws.

Methods and systems for modifying tissue use a pressurized fluid stream carrying coherent light energy. The methods and systems may be used for resecting and debulking soft and hard biological tissues. The coherent light is focused within a stream of fluid to deliver energy to the tissue to be treated.

Methods and systems for modulating intraosseous nerves (e.g., nerves within bone) are provided. For example, the methods and systems described herein may be used to modulate (e.g., denervate, ablate) basivertebral nerves within vertebrae. The modulation of the basivertebral nerves may facilitate treatment of chronic back pain. The modulation may be performed by a neuromodulation device (e.g., an energy delivery device).

Methods and systems for modifying tissue use a pressurized fluid stream carrying coherent light energy. The methods and systems may be used for resecting and debulking soft and hard biological tissues. The coherent light is focused within a stream of fluid to deliver energy to the tissue to be treated.

Devices, systems, and methods to measure a baseline temperature of a tissue prior to a laser ablation procedure are disclosed. The devices can be a thermometer including an optical fiber probe and a catheter. The catheter includes nanodiamonds embedded into a wall of the catheter. The nanodiamonds are excited by light from the optical fiber probe to emit a temperature dependent fluorescent light that is received by the optical fiber probe and transmitted to a temperature sensor. The temperature sensor can process the fluorescent light to calculate a temperature. The thermometer can be positioned adjacent to or within a target tissue structure prior to a laser ablation procedure to measure the baseline temperature. The baseline temperature can be input into a magnetic resonance imaging system to calculate a thermal damage estimate.

The present disclosure relates to a fat-removing surgical instrument. The present disclosure additionally arranges/provides, on a lipolyzed fat suction passage of a wave-guide tube, an optical fiber support which is made from an insulating material and which supports optical fibers in a restrained state while fixed to the wave-guide tube, so that the optical fibers are prevented from being deformed and coming in contact with the wave-guide tube, and thus, the optical fibers are induced, even though a variety of factors (for example, weight, contact with human tissue and the like) are applied to the optical fibers during fat removal surgery, to effectively avoid coming in direct contact with the wave-guide tube and being damaged thereby, while a series of deformations (for example, a curved shape and the like) are inhibited/controlled, on the basis of forceful restraint of the optical fiber support.

Unitary endoscopic vessel harvesting devices are disclosed. In some embodiments, such devices may comprise an elongated body having a proximal end and a distal end. A conical tip may be disposed at the distal end of the elongated body. In addition, the surgical instrument may include one or more surgical instruments moveable in a longitudinal direction along an axis substantially parallel to a central longitudinal axis of the cannula from a retracted position proximally of a distal end of the tip to an advanced position toward the distal end of the tip to seal and cut a blood vessel.

Systems and methods are configured to detect and/or ablate cancerous tissue, such as during surgery. The system uses Laser Ramen Spectroscopy (LRS) or Surface Enhanced Raman Spectroscopy (SERS) to enhance a detection signal pursuant to a spectroscopy analysis of tissue. Rapid in situ detection of cancer can be combined with immediate laser thermal ablation of the cancerous tissue. The detection and ablation can occur before, during, or after surgical resection.