A variable length interstitial probe apparatus includes: a probe for effecting thermal therapy and/or cryotherapy to a tissue; a flexible umbilical sheath permanently affixed to the probe, including at least one interface for supplying energy, cooling fluid, cooling gas, heating fluid, and/or heating gas to the probe; and an adjustable depth stop configured to slide along a length of a shaft region of the probe, and lock to the shaft region at a selected position. The adjustable depth stop is configured to engage a probe driver and/or a skull mount apparatus to stabilize positioning of the probe and to control a depth of entry of the probe into a patient. The probe may be configured to effect temperature modulation therapy, where processing circuitry activates a modulation pattern of thermal therapy emission and cryogenic therapy emission for applying a thermal dose to the tissue.

A medical system includes an insertion device including a handle and a delivery portion, a laser fiber, a conductive wire, and a lock. The laser fiber extends through the insertion device and is coupled to a laser slider to control a position of the laser fiber relative to a distal end of the delivery portion. The conductive wire extends through the insertion device and is coupled to a wire slider to control a position of the laser fiber relative to a distal end of the delivery portion. The lock is positioned within the handle and is movable in order to selectively lock either the movement of the laser slider or lock the movement of the wire slider.

A medical system includes an insertion device including a handle and a delivery portion, a laser fiber, a conductive wire, and a lock. The laser fiber extends through the insertion device and is coupled to a laser slider to control a position of the laser fiber relative to a distal end of the delivery portion. The conductive wire extends through the insertion device and is coupled to a wire slider to control a position of the laser fiber relative to a distal end of the delivery portion. The lock is positioned within the handle and is movable in order to selectively lock either the movement of the laser slider or lock the movement of the wire slider.

A method of treating a subject having glaucoma comprises performing excimer laser trabeculostomy (ELT) on a subject having glaucoma and having previously undergone a failed treatment or a treatment that has been rendered ineffective by progression of the disease. In some examples, the failed treatment is a non-surgical treatment comprising administering medicated eye drops. In some examples, the failed treatment is a laser treatment or surgical treatment, such as a trabeculoplasty, iridotomy, iridectomy, trabeculectomy, trabeculotomy, goniotomy, surgical insertion of a shunt or implant, deep sclerectomy, viscocanalostomy, or a combination thereof.

The present disclosure provides a method and a system for treating a tissue using photodynamic therapy (PDT). A photosensitizer is administered to the tissue and one or more optical fibers are placed in the tissue. A treatment light is applied to the tissue by way of the one or more optical fibers. A temperature of the tissue is measured during application of the treatment light, and a fluence rate of the treatment light is modified based on the temperature of the tissue. For example, the fluence rate may be modified to be lower if the temperature of the tissue is higher than a predetermined threshold.

A method of generating a treatment plan for delivering treatment light for intracavitary photodynamic therapy to a targeted region within a cavity of a patient may include receiving shape information for an interior surface of the cavity. A first set of control points located on a first trajectory within the cavity is initialized by assigning, to each of the first set of control points, one or more axis positions of a treatment light emitter relative to the interior surface of the cavity. A simulated total treatment dose is iteratively optimized relative to a set of one or more optimization goals when the treatment light emitter is activated to emit treatment light at each of the first set of control points. The treatment plan is then generated to provide a total treatment dose to the targeted region.

The present invention provides a system and method for treating artery having atherosclerosis. The system comprises a flexible device for wrapping around the diseased artery, at least an imaging fiber and/or an ablation fiber removably adapted on the inner side of the flexible device for imaging and/or treating the said artery and a controller for controlling the process of imaging or treatment on the said artery.

A method and delivery system are disclosed for creating an aqueous flow pathway in the trabecular meshwork, juxtacanalicular trabecular meshwork and Schlemm's canal of an eye for reducing elevated intraocular pressure. Pulsed laser radiation is delivered from the distal end of a fiber-optic probe sufficient to cause photoablation of selected portions of the trabecular meshwork, the juxtacanalicular trabecular meshwork and an inner wall of Schlemm's canal in the target site. The fiber-optic probe may be advanced so as to create an aperture in the inner wall of Schlemm's canal in which fluid from the anterior chamber of the eye flows. The method and delivery system may further be used on any tissue types in the body.

The present invention relates to an optical apparatus for skin treatment and to a method for controlling the optical apparatus. The optical apparatus includes a radiating part for radiating light generated in a light-generation part onto a target position of the skin, a cooling part for spraying cooling gas onto the target position to cool the surface of the skin, and a control part for controlling operations of the radiating part and cooling part. The control part controls the radiating part and the cooling part such that the radiating part radiates a first light onto the target position, the cooling part sprays the cooling gas onto the target position, and then the radiating part radiates a second light onto the target position.

A modular handpiece having a proximal handle module with a handle unit having at least one interior fluid cavity, having an exterior gripping surface, defining a fluid control port enabling fluid communication between the atmosphere and the interior fluid cavity, and capable of accommodating at least one waveguide for carrying optical radiation and capable of accommodating at least one RF electrode. The handpiece further comprises a cannula module having a distal portion with a distal tip, a central portion, and a proximal portion connectable with the handle module. All three cannula portions are capable of at least one of (a) defining a waveguide conduit, (b) carrying at least one RF electrode, and (c) defining a fluid passageway between the distal tip and the interior fluid cavity of the handle unit.