A method for determining parameters for operating a light source within a photo-thermal targeted treatment system is disclosed. The method includes cooling a treatment location, administering first laser pulses at the treatment location, the first laser pulses having thermal energy below a known damage threshold, tracking skin surface temperatures at the treatment location while administering the first laser pulses, estimating a relationship between parameters for operating the light source and the skin surface temperature by fitting tracked skin surface temperature to a correlation model, determining a safe operating range for the light source to avoid thermal damage at the treatment location while still effectively targeting the chromophore, administering second laser pulses at the treatment location, the second laser pulses staying within the safe operating range for the light source, and adjusting the light source according to the tracked skin surface temperatures to stay within the safe operating range.

A temperature measurement system for measuring a temperature of a measured surface includes: 1) a first temperature sensor; and 2) a reference surface including a second temperature sensor integrated therein. The first temperature sensor includes a field of view simultaneously covering both at least a portion of the measured surface and at least a portion of the reference surface, thus is configured for simultaneously taking a first measurement of both the portion of the measured surface and the portion of the reference surface. The first measurement of the reference surface taken by the first temperature sensor is compared to a second measurement taken by the second temperature sensor for use in calibrating the first temperature sensor.

A system including a thermal sensor with an instrument placed in a volume. The thermal sensor may be useful in determining a temperature at a surface of the instrument and a distance away from the instrument. A therapy may be performed based on a sensed temperature with the thermal sensors.

Methods for treating post-traumatic stress disorder (PTSD) and/or for reducing a risk associated with developing PTSD in patients via therapeutic renal neuromodulation and associated systems are disclosed herein. Sympathetic nerve activity can contribute to several cellular and physiological conditions associated with PTSD as well as an increased risk of developing PTSD following a traumatic event. One aspect of the present technology is directed to methods for improving a patient's calculated risk score corresponding to a PTSD status in the patient. Other aspects are directed to reducing a likelihood of developing PTSD in patients presenting one or more PTSD risk factors. Renal sympathetic nerve activity can be attenuated to improve a patient's PTSD status or risk of developing PTSD. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly configured to use, e.g., electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the renal sympathetic nerve.

A diode laser system having high-power diode(s) said high-power diode(s) producing laser outputs in a range of 0.1 to 25 Watts of power using optimum wavelengths via a single optical delivery fiber.

Embodiments of the invention provide a hollow cable for conveying radiofrequency and/or microwave frequency energy to an electrosurgical instrument that can fit within, e.g. slide relative to, the hollow cable. The hollow cable provides a bipolar electrical connection to the electrosurgical instrument that is maintained when the electrosurgical instrument is rotated relative to the hollow cable. The cable may comprise a hollow coaxial transmission line having a rotatable component mounted at its distal end. The rotatable component comprises a longitudinal passageway continuous with the hollow coaxial transmission line. The rotatable component is rotatable relative to the transmission line and comprises a first and second conductive portions that are respectively electrically connected to first and second terminals on the coaxial transmission line and which are configured to maintain an electrical connection with their respective terminal when rotated relative to the coaxial transmission line.

Embodiments of the invention provide a hollow cable for conveying radiofrequency and/or microwave frequency energy to an electrosurgical instrument that can fit within, e.g. slide relative to, the hollow cable. The hollow cable provides a bipolar electrical connection to the electrosurgical instrument that is maintained when the electrosurgical instrument is rotated relative to the hollow cable. The cable may comprise a hollow coaxial transmission line having a rotatable component mounted at its distal end. The rotatable component comprises a longitudinal passageway continuous with the hollow coaxial transmission line. The rotatable component is rotatable relative to the transmission line and comprises a first and second conductive portions that are respectively electrically connected to first and second terminals on the coaxial transmission line and which are configured to maintain an electrical connection with their respective terminal when rotated relative to the coaxial transmission line.

Resonance Raman scatter is used to differentiate in quasi-real time (QRT) surfaces bearing pathogens from adjacent pathogen-free surface regions. The fingerprint generated from pathogens on a selected surface by a 1 second pulse of 532 nm emission for approximately one second is collected and is relayed by fiber-optic to a computerized controller that determines whether the target selected surface is contaminated by pathogens or is pathogen-free. If contaminated the pathogens are eradicated by UVC radiation. This is performed by a pattern of Resonance Raman diagnostic emission and diagnostic sensor fibers. The data received by the computer is examined instantly, and should the site be diagnosed as contaminated with pathogens, UVC radiation is repeated immediately and repeated until the selected surface is read as being pathogen-free.

Resonance Raman scatter is used to differentiate in quasi-real time (QRT) surfaces bearing pathogens from adjacent pathogen-free surface regions. The fingerprint generated from pathogens on a selected surface by a 1 second pulse of 532 nm emission for approximately one second is collected and is relayed by fiber-optic to a computerized controller that determines whether the target selected surface is contaminated by pathogens or is pathogen-free. If contaminated the pathogens are eradicated by UVC radiation. This is performed by a pattern of Resonance Raman diagnostic emission and diagnostic sensor fibers. The data received by the computer is examined instantly, and should the site be diagnosed as contaminated with pathogens, UVC radiation is repeated immediately and repeated until the selected surface is read as being pathogen-free.

A tool has a handle and an elongate shaft that extends distally from the handle. A distal portion of the shaft is inserted into a subject during a surgical procedure. An optical fiber delivers laser energy to a tip at the distal portion of the shaft. The tip includes a mechanical cutting mechanism including a moving part that absorbs the laser energy, thermally conducts the absorbed energy to tissue that is disposed between the moving part and another part, and moves with respect to the other part in order to cut tissue that is disposed between the parts using a mechanical force that is lower than a mechanical force that would be required to cut the tissue in the absence of the laser energy. Other embodiments are also described.