A disposable marker for use in preparation for medical procedures. The marker is made of plastic or such similar material that does not show up on an x-ray monitor. The marker includes one or more metallic elements that have an elongated aspect disposed in proximity to the marker tip. As such, a clinician may introduce the marker into an x-ray field and view it in space by following the metallic element an x-ray monitor.

Tissue localization devices and methods of localizing tissue using tissue localization devices are disclosed. The tissue localization device can comprise a handle comprising a delivery control, a delivery needle extending out from the handle, and a localization element within the delivery needle. The localization element can be deployed out of the delivery needle or retracted back into the delivery needle when the delivery control is translated in a first direction or a second direction, respectively. The localization element can be coupled to a flexible tracking wire.

Systems and methods for detecting metal clips inserted within a portion of a body of a patient are disclosed herein. In one embodiment, a clip detector assembly includes a detector having a ferrous member, a transmitting coil around the ferrous member and configured to induce a current in the metal clip, and a receiving coil around the ferrous member and configured to receive a magnetic field generated by the current induced in the metal clip. The assembly can further include a control circuit having a band-pass filter configured to pass electrical signals induced by the magnetic field from the receiving coil that are within at most 35 kHz of a resonance frequency of the metal clip. The assembly still further includes a user notification component configured to alert a user to a location of the metal clip.

Valve devices for replacement of mitral valves while preserving valvular and subvalvular mitral valve apparatus. The valve device may be configured as a double orifice valve replacement device, and may include an anchoring and manifold assembly coupleable to a delivery catheter. The assembly may include means for anchoring the device to the mitral valve or to a fixation device already attached to the mitral valve. A peripheral ring anchoring system secured to the assembly may include at least one expandable anchoring ring that is expandable within an orifice of the mitral valve so as to surround the orifice perimeter. A helical suture may be helically disposable about the ring, securing the ring to adjacent leaflet tissue. A trap door valve including a trap door body that seals against the anchoring ring during systole and unseals during the diastolic portion of the cardiac cycle may be provided.

Targeted ablation of parathyroidal tissue is provided through hyperthermia adjuvant therapy. An in situ localization of parathyroidal tissue is obtained. A temperature-sensitive adjuvant is instilled into the parathyroidal tissue. Hyperthermia is therapeutically induced within the parathyroidal tissue. Heat-inducing energy is targeted into the parathyroidal tissue, which selectively includes the temperature-sensitive adjuvant. Application of the heat-inducing energy to the parathyroidal tissue is continued over a therapeutic range. In a further embodiment, the targeted ablation of the parathyroidal tissue is provided through hypothermia adjuvant therapy with the targeted use of cold-inducing energy.

A biopsy system comprises an introducer and a biopsy device. The introducer comprises a cannula and at least two leaves. The cannula comprises an ovular cross-section, an open distal end and an open proximal end. The ovular cross-section defines a lumen extending between the open distal end and the open proximal end. The ovular cross-section of the cannula includes at least two flat sides. The at least two leaves extend distally from the open distal end. At least a portion of each of the at least two leaves extend from a respective flat side of the at least two flat sides of the cannula. The biopsy device comprises a body and an elongate needle. The elongate needle extends distally from the body. The elongate needle includes an ovular cross-section defining two straight sides. The cannula of the introducer is configured to slidably receive the elongate needle of the biopsy device.

Provided herein are systems, devices, assemblies, and methods for generating exciter signals, for example, to activate a remotely located tag. The systems, devices, assemblies, and methods find use in a variety of application including medical applications for the locating of a tag in a subject.

This document provides methods and devices for localizing, delineating and/or anchoring lesions for resection from a solid organ (e.g., liver, breast, or pancreas). For example, this document provides devices that can be positioned within liver tissue to help delineate liver tumor tissue from normal liver tissue and to help hold liver tumor tissue in position for resection.

A peroperative probe for guiding a manual excision tool. The probe includes a detection head, an optical fiber for the reception and guidance of a signal emitted by radioactive tracers and fluorescent molecules in a tissue area, a photo-detector for converting the emitted signal into an electrical signal, a transmitter for transmitting information carried by the electrical signal to an analysis equipment, and a fastener for attaching the probe onto the manual excision tool, so that the excision tool can be used to remove a portion of tissue from the tissue area emitting the signal.

A dilation assembly comprises an expandable and contractible main body having a corrugated outer surface, a guide cannula configured to be disposed through the main body to guide a movement of the main body, and an anchor configured to fix the main body in a target position.