This invention relates to apparatus and method for detection of human skin lesion malignancy. The method relies on two independent wavelengths regions: (a) visible and Near IR circa (0.4-1.3 um); (b) Far Infrared (6-12 um). The visible and NIR wavelengths will analyze sub-skin scattering and absorbance to detect structural and diffusion abnormalities, and the FIR wavelengths will monitor the thermal blood perfusion, as reflected by monitoring temperature variation of suspected region. An apparatus according to the present invention would comprise a cooling/heating component which encloses the suspected area, MIR camera or thermal sensors, visible and NIR camera. Evaluation of the rate of the skin temperature changes and propagation in the suspected area will enable to detect increased blood perfusion and metabolic heat, identifying alarming signals related to skin diseases. Parallelly, the sub-skin density and coagulation will be analyzed by peripheral illumination. Evaluation procedure will include image analysis and artificial intelligence to enhance the detection capabilities. Using two independent technologies minimizes the false-negative detection and increases sensitivity and specificity. This invention relates to different body parts without limitations.

An optical tomography device includes a carrier base, at least one slide rail, at least one sliding assembly, and at least one optical channel member. The carrier base has a through hole. The slide rail is located on the carrier base and extends toward the through hole. The sliding assembly includes a sliding block, a guiding rod, and an elastic component. The sliding block is slidably connected to the slide rail and has a first restriction portion. The guiding rod is slidably connected to the sliding block and has a second restriction portion. The elastic component is configured to be deformed by the first restriction portion and the second restriction portion. The optical channel member is coupled with the guiding rod.

A wearable device is described. The wearable device includes a housing having a back cover, and an optical mask on first portions of the back cover. The back cover includes a set of windows, with a first subset of windows in the set of windows being defined by an absence of the optical mask on second portions of the back cover, and a second subset of windows in the set of windows being inset in a set of openings in the back cover. An optical barrier surrounds each window in the second subset of windows. A set of light emitters is configured to emit light through at least some of the windows in the set of windows. A set of light detectors is configured to receive light through at least some of the windows in the set of windows.

An apparatus and method of measuring oxygenation of tissue in a non-invasive manner are provided. The apparatus comprises a light source configured to emit a light pattern to be projected onto the tissue, in which the light pattern comprises superimposed patterns having different patterns. A detector captures an image of a reflected light pattern which is reflected from the tissue as a result of the projected light pattern. A processor coupled to the detector can be configured to perform a transform on the image of the reflected light pattern and determine oxygenation of each of a plurality of layers of the tissue in response to the transform of the image. Polarimetry can be used in determining a change in polarization angle of light beam. Tissue oxygenation can be determined at a plurality of layers from one snapshot, for example oxygenation of retinal layers.

Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes one or more electrodes configured to apply RF energy to a portion of a sample in contact with the electrode. The distal section also includes a plurality of optical elements configured to transmit one or more beams of exposure radiation away from the distal section of the catheter. The proximal section includes an optical source configured to generate a source beam of radiation and a detector configured to generate depth-resolved optical data. The multiplexer is configured to generate the one or more beams of exposure radiation from the source beam of radiation.

An oximeter probe is user configurable for being in an absolute reporting mode and a relative reporting mode for measured values. The measured values for the absolute and relative modes include absolute oxygen saturation, relative oxygen saturation, absolute hemoglobin content, relative hemoglobin content, absolute blood volume, relative blood volume. The relative modes and absolute modes for determining and reporting relative or absolute hemoglobin content or relative or absolute blood volume for individual patients are beneficial when determining the efficacy of administered medications, such as epinephrine, that effect blood flow, but not oxygen saturation, in tissue, such as skin. The oximeter probe in these relative modes displays the efficacy of the administered medication as reported values for relative hemoglobin content or relative blood volume fall or rise.

A forward looking MEMS based OCT probe (50) is provided that comprises an elongate probe housing (51) having at a first end a probe interface (54) for an optic fibre (56), and at a second opposite end a viewing window (58). The probe housing accommodates a MEMS mirror (10) for sweeping a hght beam (60) through the viewing window and for reflecting light received through the viewing window towards the probe interface, wherein a rotation axis (18) of the MEMS mirror extends transverse to a longitudinal axis (62) defined by the probe housing. The MEMS mirror (10) has a stator (12), a rotor (14), and an actuator (16) with at least one pair of mutually interdigitated comb elements including at least a first comb element fixed to the stator defining a reference plane and at least a second comb element fixed to the rotor and that is further coupled at mutually opposite sides via a respective torsion beam (20A, 20B) to the stator. The rotor has a rotor body (14RB) and a rotor support (14RS), fixed at a first face of the rotor body, that keeps the rotor body at a distance from the stator within said rotation range, the rotor body having a mirror surface (14MS) at a second face opposite the first face, the MEMS mirror comprising the stator (12) and the rotor support (14RS) at mutually opposite sides of the reference plane (RP).

An irradiation device comprises a light source, an optical switch element and an image recognition module communicatively connected to the optical switch element. In some embodiments, a contour of a target area is recognized by an image recognition module and is provided by the image recognition module to the optical switch element, and a contour of an irradiation area of the light source is controlled by the optical switch element to match with the contour of the target area according to the contour of the target area provided by the image recognition module. Thus, when skin diseases are treated using the irradiation device according to some embodiments of the present disclosure, the contour of the irradiation area of the light source coincides with the contour of the target area, thereby ensuring a therapeutic effect with respect to the target area while avoiding damages to skin in a healthy area.

A photoelectric sensor module includes a first light emitting element that emits light having a first wavelength, a second light emitting element that emits light having a second wavelength different from the first wavelength, and a light receiving element that receives light emitted from the first light emitting element and reflected by an object and light emitted from the second light emitting element and reflected by the object are mounted on a substrate with linear edges. With respect to a virtual straight line defined on a surface of the substrate, a light emitting portion of the first light emitting element and a light emitting portion of the second light emitting element are line-symmetric, a light receiving portion of the light receiving element is line-symmetric, and a shape of the substrate in plan view is line-symmetric.

An apparatus for estimating a biological substance in a user using a unit spectrum for the biological substance acquired using a biological tissue simulation solution is provided. The apparatus may include a spectrometer configured to emit a light to a skin of a user, detect the light returned from the skin, and measure a skin spectrum of the user from the detected light and a processor configured to estimate a biological substance in the user based on the measured skin spectrum and a unit spectrum acquired using a biological tissue simulation solution.