A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.

Disclosed are methods and systems for: (i) sequentially illuminating a specimen with different spatial distributions of light, wherein each illumination causes an object embedded in the specimen to emit radiation in response to the light; (ii) for each different spatial distribution of illumination light, imaging the radiation emitted from the specimen from each of multiple sides of the specimen; and (iii) determining information about the object in the specimen based on the imaged radiation from each of the multiple sides for each of the different spatial distributions of illumination light.

A system configured to perform the DCS-type measurements with the use of low-coherence continuous-wave (CW) light source at levels of light intensities that are substantially lower and with pathlengths through the tissue that are substantially longer than those afforded by the use of conventional methods. The method includes utilizing the optical detection system to producing signals representing interference between the portion of CW light arriving through reference arm of interferometer and the sample CW light potion that has traversed the sample arm including different paths through the target tissue while switching between first and second of said different paths only by adjusting a delay in the delay line. The spatial resolution of different pathlengths of sample light through tissue is defined by coherence length of CW light.

Featured are methods, apparatus and devices for detecting a hematoma in tissue of a patient. In one aspect, such a method includes emitting near infrared light continuously into the tissue from a non-stationary near infrared light emitter and continuously monitoring the tissue using a non-stationary probe so as to continuously detect reflected light. The near infrared light is emitted at two distances from a brain of the patient, so the emitted light penetrates to two different depths. Such a method also includes applying a ratiometric analysis to the reflected light to distinguish a border between normal tissue and tissue exhibiting blood accumulation.

An apparatus for estimating a biological substance in a user using a unit spectrum for the biological substance acquired using a biological tissue simulation solution is provided. The apparatus may include a spectrometer configured to emit a light to a skin of a user, detect the light returned from the skin, and measure a skin spectrum of the user from the detected light and a processor configured to estimate a biological substance in the user based on the measured skin spectrum and a unit spectrum acquired using a biological tissue simulation solution.

An apparatus and method of measuring oxygenation of tissue in a non-invasive manner are provided. The apparatus comprises a light source configured to emit a light pattern to be projected onto the tissue, in which the light pattern comprises superimposed patterns having different patterns. A detector captures an image of a reflected light pattern which is reflected from the tissue as a result of the projected light pattern. A processor coupled to the detector can be configured to perform a transform on the image of the reflected light pattern and determine oxygenation of each of a plurality of layers of the tissue in response to the transform of the image. Polarimetry can be used in determining a change in polarization angle of light beam. Tissue oxygenation can be determined at a plurality of layers from one snapshot, for example oxygenation of retinal layers.

A non-contact brain blood oxygen detecting system includes a mobile terminal device. The mobile terminal device includes a control module, a transmitting module, a receiving module and a display module. The control module is connected to the transmitting module, the receiving module and the display module, respectively. The transmitting module in the mobile terminal device is configured to emit dual-wavelength near-infrared light to a detected subject. The receiving module is configured to receive a light signal after propagation fed back by the detected subject, and to perform data conversion on the received light signal to obtain a digital signal containing blood oxygen information. The control module is configured to obtain the blood oxygen information of the detected subject according to the digital signal obtained by the receiving module. The display module is configured to display the blood oxygen information obtained by the control module.

A bio imaging system includes a substrate, a light source on the substrate, and a sensor on the substrate, wherein at least one of the light source or the sensor is configured to emit or absorb light of different wavelength spectrum. The bio imaging system is configured to combine a plurality of images obtained based on the light of different wavelength spectra to obtain a three-dimensional image of an internal tissue of a living body.

Source light having a range of optical wavelengths is generated. The source light is split into sample light and reference light. The sample light is delivered into a sample, such that the sample light is scattered by the sample, resulting in signal light that exits the sample. The signal light and the reference light are combined into an interference light pattern having optical modes, each having a direct current (DC) component and at least one alternating current (AC) component. Different subsets of the optical modes of the interference light pattern are respectively detected, and analog signals representative of the optical modes of the interference light pattern are output. Pair of the analog signals are subtracted from each other, and differential analog signals are output. The sample is analyzed based on the differential analog signals.

Disclosed are a probe for photoacoustic measurement which can suppress generation of artifacts obstructive to signal observation in a photoacoustic measurement, and a photoacoustic measurement apparatus including the same. The probe for photoacoustic measurement includes a light emission unit which emits measurement light to a subject, and an acoustic wave detection unit which detects a photoacoustic wave generated in the subject by the emission of measurement light. An emission end surface of the light emission unit is positioned to a side where the acoustic wave detection unit is located, with respect to a contact plane of the probe, and an optical axis at the emission end surface is inclined to a side opposite to the side on which the acoustic wave detection unit is positioned with respect to a normal direction of a detection surface of the acoustic wave detection unit.