In an example, physiological signal(s) are received from physiological sensor(s) configured to measure at least one physiological property of a user. An arousal of at least one characteristic of at least one treatment resistant mood disorder is detected through employment of an estimation method based at least in part on at least one of the physiological signal(s). A value for at least one of a plurality of stimulation parameters is selected based at least in part on at least one of the physiological signal(s). An electric field based at least in part on the arousal is produced. The electric field is configured to stimulate at least a portion of a median nerve of the user transcutaneously. The electric field is based at least in part on at least some of the plurality of stimulation parameters.

A method of monitoring a patient's foot forms a thermogram of the sole of at least one foot of the patient, and determines whether the thermogram presents at least one of a plurality of prescribed patterns. The method also compares the thermogram against a prior thermogram of the same foot, and produces output information indicating the emergence of an ulcer on a given portion on the at least one foot as a function of 1) whether the thermogram is determined to present the at least one pattern, and 2) the comparison with the prior thermogram, which shows non-ulcerated tissue at the given location.

A measurement system includes: a sensor wire comprising an insertable portion configured to be inserted in a blood vessel of a patient's body; a sensor disposed at the insertable portion at a distal end of the sensor wire, wherein the sensor is configured to provide an output indicative of a temperature in the blood vessel of the patient's body, when inserted inside the blood vessel of the patient's body; and a transceiver unit configured to transfer information related to the output of the sensor to an external communication module using a frequency hopping technique. The transceiver unit comprises a housing adapted to be connected to a proximal end of the sensor wire and configured to remain external to the patient's body.

An elongated device and a system that at the same time allow acquisition of temperature-related data of high spatial and temporal resolution from hollow structures together with other relevant data of physical or chemical variables. In a preferred embodiment infrared or visible light sensors are used to obtain thermal or color images from the inner surface during imposed change of the temperature in the lumen of the hollow structure. The disclosure makes it possible to evaluate thermal variations when the inner surface returns to pre-change thermal conditions. High-resolution data can be obtained with the disclosure. The disclosure further includes a system with rotators, injection pumps, a control unit and display operably coupled to one or more of the data acquisition and processing system.

An electronic device comprises an enclosure configured for insertion into the ear canal and comprising a distal end configured to extend at least beyond a first bend of the ear canal. A distal temperature sensor is situated at a location of the enclosure that faces a tragus-side of the ear canal between the first and second bends when the enclosure is fully inserted into the ear canal. A proximal temperature sensor is situated on the enclosure at a location spaced apart from a surface of the ear canal and proximal of the distal temperature sensor in an outer ear direction when the enclosure is fully inserted into the ear canal. A processor, coupled to the distal and proximal temperature sensors and to memory, is configured to calculate an absolute core body temperature using a heat balance equation stored in the memory and the first and second temperature signals.

The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.

Systems for detecting contact between an electrode and a patient's skin using one or more contact detection schemes are provided. An example system can include an electrode assembly comprising at least one electrode configured to be disposed substantially proximate to the patient's skin and configured to at least one of sense an ECG signal of the patient and provide one or more therapeutic pulses to the patient, one or more sensors disposed on the electrode assembly and isolated from the electrode, the sensors configured to measure one or more properties to determine contact between the electrode and the patient's skin, and a controller configured to receive data representing the measured one or more properties and determine, based at least in part on the received data, whether the electrode is in contact with the patient's skin. The sensors can include temperature, impedance, capacitance, optical, and other similar sensors.

A camera attachment for measuring a temperature of a surface, and related methods of measuring the temperature of the surface, employ a temperature reactive material that is thermally coupled with the surface and imaged to provide image data of the temperature reactive material that is analyzed to measure the temperature. A camera attachment for measuring a temperature of a surface includes a distal surface configured to be thermally coupled with the surface, a frame configured to be coupled with a camera that has a field of view, and a temperature reactive material coupled with the frame and thermally coupled with the distal surface. The frame positions the temperature reactive material within the field of view of the camera so that an image captured by the camera includes at least a portion of the temperature reactive material.

A measurement system includes: a sensor wire comprising an insertable portion configured to be inserted in a blood vessel of a patient's body; a sensor disposed at the insertable portion at a distal end of the sensor wire, wherein the sensor is configured to provide an output indicative of a temperature in the blood vessel of the patient's body, when inserted inside the blood vessel of the patient's body; and a transceiver unit configured to transfer information related to the output of the sensor to an external communication module using a frequency hopping technique. The transceiver unit comprises a housing adapted to be connected to a proximal end of the sensor wire and configured to remain external to the patient's body.

A thermosensitive nanosensor includes a substrate having a plurality of vertically standing nanostructures attached thereto, the plurality of vertically standing nanostructure being covered with a conductive material to form conductive coated nanostructures; a thermosensitive hydrogel adjacent to the plurality of conductive coated nanostructures; and a cover layer on top of the thermosensitive hydrogel to prevent loss of moisture and mechanical stress.