A flexible photonic skin is provided, including a functional layer, an adhesive layer used for fixing the functional layer and made of hypoallergenic polyvinyl ethyl ether, and a packaging layer made of a polyurethane semi-transparent film and adhered to the adhesive layer, which are arranged successively from the top down, wherein the functional layer consists of two electrodes located on two sides and used for acquiring electrocardiographic signals of a human body, and a polymer-based photonic integrated chip located between the two electrodes and used for acquiring body temperature, pulse, blood pressure and blood glucose signals of the human body; and, the polymer-based photonic integrated chip processes and outputs the acquired electrocardiographic signals of the human body as well as the body temperature, pulse, blood pressure and blood glucose signals of the human body.

A regional oximetry pod drives optical emitters on regional oximetry sensors and receives the corresponding detector signals in response. The sensor pod has a dual sensor connector configured to physically attach and electrically connect one or two regional oximetry sensors. The pod housing has a first housing end and a second housing end. The dual sensor connector is disposed proximate the first housing end. The housing at least partially encloses the dual sensor connector. A monitor connector is disposed proximate a second housing end. An analog board is disposed within the pod housing and is in communications with the dual sensor connector. A digital board is disposed within the pod housing in communications with the monitor connector.

An implantable optical sensor comprises a photonic integrated circuit comprising a substrate 2 and an optical microstructure 3 integrated with the substrate 2. The optical microstructure is positioned to form an exposed optical interaction area 4 on a part of a surface 5 of the substrate 2. A cover cap 6 is sealed onto a part of the substrate 2 adjacent to the optical interaction area 4 and by wafer-to-wafer bonding technology or another wafer-level hermetic packaging technique. At least one active component 8 is positioned in a sealed cavity 9 which is formed between the surface 5 and the cover cap 6. The substrate 2 comprises at least one optical feedthrough 10, which is an embedded waveguide extending from the sealed cavity 9 to the optical interaction area 4.

A system and apparatus comprising a multisensor guidewire for use in interventional cardiology, e.g., Transcatheter Valve Therapies (TVT), comprises a plurality of optical sensors for direct measurement of cardiovascular parameters, e.g. transvalvular blood pressure gradients. The guidewire has flexibility and stiffness characteristics for use as a support guidewire for TVT, e.g. for Transcatheter Aortic Valve Implantation (TAVI), comprises multiple optical pressure sensors and respective optical fibers, and a pre-formed three-dimensional flexible tip, e.g. in the form of a helix. The three-dimensional pre-formed tip is configured to assist with anchoring the guidewire within one of the ventricles and atria of the heart, or within the pulmonary artery or aorta, during interventional cardiology procedures.

Dental handpieces, motors, couplers and other dental instruments and methods having multiple very small, high output, LEDs in a single lamp assembly to facilitate incorporation of a plurality of wavelengths emitted from these devices to allow dentists to select between the benefits of multiple wavelength light outputs to the working area in a single device.

A system (1) and apparatus comprising a multisensor guidewire (100/200/300) for use in interventional cardiology, e.g., Transcatheter Valve Therapies (TVT), comprises a plurality of optical sensors (10/20) for direct measurement of cardiovascular parameters, e.g. transvalvular blood pressure gradients and flow. A conventional outer coil wire (35) contains a shaped core wire (31) having a cross-section defining a channel surface (132), e.g. grooves (32), extending along its length, to position optical fibers (11) and optical sensors (10/20) in a channel (33). Advantageously, the core wire has a diameter that provides sufficient stiffness to the guidewire for use as a support guidewire for TVT, e.g. Transcatheter Aortic Valve Implantation (TAVI), while accommodating multiple sensors and fibers within a guidewire of outside diameter 0.89 mm. An optical connector (112) couples the guidewire to a control system (150). Optionally, the guidewire includes a contact force sensor (60), a pre-formed tip (400-1/400-2) and a separable micro-connector (140).

Devices and methods for visually confirming the positioning of a distal end portion of an illuminating device placed within a patient include inserting a distal end portion of an illuminating device internally into a patient, emitting light from the distal end portion of the illuminating device, observing transillumination resulting from the light emitted from the distal end portion of the illuminating device that occurs on an external surface of the patient, and correlating the location of the observed transillumination on the external surface of the patient with an internal location of the patient that underlies the location of observed transillumination, to confirm positioning of the distal end portion of the illuminating device.

A regional oximetry sensor can have a sensor head configured to secure to skin of a user and a stem extending from the sensor head. The sensor head can include an emitter configured to transmit optical radiation into the skin and at least one detector configured to receive the optical radiation after attenuation by blood flow within the skin. The stem can be configured to transmit electrical signals from the sensor head to a cable. A plurality of notches can extend from a perimeter of the sensor head towards an interior thereof. The plurality of notches can form a plurality of independently flexible cutouts in the sensor head configured to allow for movement of at least a portion of the skin of the user underlying the sensor head when the regional oximetry sensor is in use.

An optoelectronic sensor may include a radiation source designed to emit electromagnetic radiation, a receiver designed to receive a reflection of the radiation, an optical waveguide optically coupled to the radiation source, and/or to the receiver so that an optical coupling region is formed to couple the radiation out of the sensor and to inject the reflection into the sensor to determine properties of a sample to be determined. The sensor may be configured to rest against a sample.

A diagnostic imaging catheter is disclosed, which is capable of preventing a solution from an internal space of a hub from flowing into a portion communicating with the internal space of the hub and to which the signal lines such as the optical fiber and the electric signal cable are electrically or optically connected. The optical diagnostic catheter includes a rotatable drive shaft, an elongated sheath configured to be inserted into a biological lumen, a hub that includes a port connected to the sheath for supplying the solution, a connector portion that includes an optical connector accommodated in an internal space of the hub and optically connected to an external optical connector, a first seal portion that prevents the solution from the port from flowing into a first connection portion, and a second seal portion that prevents the solution from the port from flowing into a second connection portion.