The present invention provides devices and methods for controlled and continuous delivery of drugs into the brain by bypassing the blood brain barrier, without the need for any surgical manipulation of the brain. The respiratory mucosa in the maxillary sinus or in the nasal region is surgically accessed from the oral or maxillofacial region through a window made on the bone overlying the mucosa. The device is used to deliver drugs in a continuous and controlled manner either beneath or above the respiratory mucosa depending on the clinical requirements, drug formulation and the volume of drug used. The drug distributes into the brain from the delivery site by bypassing the blood brain barrier without causing any significant increase of the drug in the peripheral circulation. The device can be used for continuous and controlled drug delivery into the brain by bypassing the blood brain barrier for a number of medical conditions.

An osseous anchoring implant with optimized expansion, having a tubular body and a rod whose external profile of the rod and internal profile of the tubular body are complementary. The implant being expandable between a rest configuration in which an abutment mechanism interlocks the tubular body and the rod thanks to the reversal of their two respective screw pitches, so that they provide in an expanded configuration radially: a proximal bearing point, a distal bearing point, a “central” bearing point located between these two bearing points, formed by the cooperation between the outer diameter of the rod and the inner diameter of the tubular body which induce an outer diameter of the tubular body at the “central” level greater than the outer diameter of the tubular body at the proximal bearing point.

Embodiments of the present invention provide an osseointegrative implant and related tools, components and fabrication techniques for surgical bone fixation and dental restoration purposes. In one embodiment an all-ceramic single-stage threaded or press-fit implant is provided having finely detailed surface features formed by ceramic injection molding and/or spark plasma sintering of a powder compact or green body comprising finely powdered zirconia. In another embodiment a two-stage threaded implant is provided having an exterior shell or body formed substantially entirely of ceramic and/or CNT-reinforced ceramic composite material. The implant may include one or more frictionally anisotropic bone-engaging surfaces. In another embodiment a densely sintered ceramic implant is provided wherein, prior to sintering, the porous debound green body is exposed to ions and/or particles of silver, gold, titanium, zirconia, YSZ, α-tricalcium phosphate, hydroxyapatite, carbon, carbon nanotubes, and/or other particles which remain lodged in the implant surface after sintering. Optionally, at least the supragingival portions of an all-ceramic implant are configured to have high translucence in the visible light range. Optionally, at least the bone-engaging portions of an all-ceramic implant are coated with a fused layer of titanium oxide.

A dental implant is provided, wherein the dental implant includes a dental root implant. The dental root implant forms a columnar body, and two ends thereof have a tubular portion and a joint portion, respectively, wherein the tubular portion is provided with a plurality of through holes. A central groove is formed inside the tubular portion and communicates with the through holes, wherein an inner diameter of the central groove tapers from approaching the joint portion to away from the joint portion. The joint portion can be coupled to a dental crown, and the tubular portion can be coupled to a human alveolar bone. The through holes can facilitate an osseointegration of the dental root implant in the alveolar bone.

An implant for implantation into bone tissue includes an elongated body having an outer surface. The outer surface has at least one thread. The thread makes a number of turns around the body of the implant and includes a root, a flank and a crest. The root and a segment of the flank have a roughened portion compared to the crest. A method of forming an implant having a threaded outer surface including a root, a flank, and a crest includes treating the threaded outer surface at only the root and a portion of the flank while the crest remains untreated.

A dental implant includes: a base having exterior surfaces and a plug opening formed therein; a plug assembly inserted into the plug opening; and at least one region of porous ingrowth material associated with at least one of the exterior surfaces of the base.

A multifunctional prosthetic component developed to have multiple functions within the conventional or digital workflow, in which a temporary or permanent prosthesis is made for a dental rehabilitation unit that is cemented or screwed on a dental implant. Thus, the component has a geometry that allows it to be used as a conventional closed tray transfer, conventional open tray transfer, scanbody, and temporary abutment, basically including three main regions: a lower region, an intermediate region and an upper region, being also able to cooperate with a positioner cap.

A tooth implant system is provided, comprising a fixture, protrusions, and an abutment. The fixture has a top opening portion, a bottom closed portion, an inner surface portion, an outer surface portion, and a central hole portion surrounded by the inner surface portion. The plurality of protrusions are provided on the inner surface portion of the fixture at locations of substantially same heights from the bottom closed portion and with even circumferential intervals, and each of the plurality of protrusions comprises a vertical stop and a bottom edge. The abutment comprises an upper cylindrical portion, a middle connecting portion extending from the top cylindrical portion, and a lower engaging portion extending from the middle connecting portion. The lower engaging portion of the abutment is configured to be received into the central hole portion surrounded by the protrusions and engage with the protrusions.

A dental device comprises: a dental implant comprising a core enveloped by an expandable anchor comprising a plurality of joined segments. Prior to insertion of the core into the expandable anchor a carrier apically displaces within the expandable anchor, generating an expansion force causing the plurality of joined segments to be displaced linearly away from the central axis of the implant where the coronal and apical ends of each joined segment are displaced in parallel paths normal to the central axis of the implant. The core inserts into the expandable anchor to lock the plurality of joined segments in their expanded configuration. At least a first rail on the core is received by a corresponding expandable anchor slot to align the core and expandable anchor and at least a first core and expandable locking lodge engage to lock the core into the expandable anchor.

Provided is an implant unit, and more particularly, a dental implant unit. The implant unit includes a fixture assembled to an alveolar bone; and an abutment assembled to the upper portion of the fixture, wherein the fixture includes a space defined by a groove-like structure formed in depth direction from the lower portion of the fixture facing the alveolar bone.