A method of manufacturing an article comprising: (a) performing an additive manufacturing process to firm an article in an initial state, the article comprising mounting features and being supported during the additive manufacturing process by support structures; and (h) performing a second manufacturing process to transform the article into a second state, which second manufacturing process is a subtractive process comprising: (i) mounting, via the mounting features formed during the additive manufacturing process, the article in a holding device of a machine for operating on the article, with the support structures or at least remnants thereof remaining on the article, and (ii) with the article so mounted in the holding device, processing at least one feature on a surface of the article on which the support structures were provided to remove material on the at least one feature provided by the support structures.

A customizable implant made of plastic including a thermoplastic which is reinforced with long fibers arranged multidirectionally in a targeted manner and has a modulus of elasticity E of 10-70 GPa is provided. A system for producing a customizable implant including a device for collecting patient data regarding the environment into which an implant is to be inserted, a computer program for creating a model for a customized implant based on the patient data collected, and a device for producing the customized implant based on the calculated model by means of 3D printing and/or laser sintering is also provided.

Custom dental prosthesis or implants each individually designed and manufactured to replace nonfunctional natural teeth positioned in a jawbone of a specific pre-identified patient are provided. An example dental prosthesis/implant includes a dental implant body having a prosthesis interface formed therein to receive an occlusal-facing dental prosthesis component. The prosthesis interface has a custom three-dimensional surface shape positioned and formed to create a form locking fit with respect to the occlusal-facing dental prosthesis component when positioned thereon.

A core for obturating a root canal includes a body that has a pre-formed contour that closely matches a contour of the root canal. When the core is inserted in the root canal with or without sealer, there are essentially no voids in the root canal. A method of making a customized root canal obturation core includes generating a three-dimensional image of a root canal. The method also includes manufacturing the customized root canal obturation core based on the three-dimensional image of the root canal. The customized root canal obturation core has a preformed contour that closely matches a contour of the root canal such that when the core is inserted in the root canal with or without sealer there are essentially no voids in the root canal.

An antibiotic-eluting article for implantation into a mammalian subject, produced by an additive manufacturing process wherein a polymeric material is concurrently deposited with a selected antibiotic. The additive manufacturing process may be a selective laser sintering process or a selective laser melting process or a selective heat sintering process or an electron beam melting process. The antibiotic-eluting article may be temporary or permanent orthopedic skeletal component, an orthopedic articulating joint replacement component, and/or an external hard-shell casing for an implantable device. One or more bone-growth-promoting compositions may be concurrently deposited with the polymeric material. The implantable device may be a cardiac pacemaker, a spinal cord stimulator, a neurostimulation system, an intrathecal drug pump for delivery of medicants into the spinal fluid, and infusion pump for delivery of chemotherapeutics and/or anti-spasmodics, an insulin pump, an osmotic pump, and a heparin pump.

Embodiments of the present invention provide an osseointegrative implant and related tools, components and fabrication techniques for surgical bone fixation and dental restoration purposes. In one embodiment an all-ceramic single-stage threaded or press-fit implant is provided having finely detailed surface features formed by ceramic injection molding and/or spark plasma sintering of a powder compact or green body comprising finely powdered zirconia. In another embodiment a two-stage threaded implant is provided having an exterior shell or body formed substantially entirely of ceramic and/or CNT-reinforced ceramic composite material. The implant may include one or more frictionally anisotropic bone-engaging surfaces. In another embodiment a densely sintered ceramic implant is provided wherein, prior to sintering, the porous debound green body is exposed to ions and/or particles of silver, gold, titanium, zirconia, YSZ, -tricalcium phosphate, hydroxyapatite, carbon, carbon nanotubes, and/or other particles which remain lodged in the implant surface after sintering. Optionally, at least the supragingival portions of an all-ceramic implant are configured to have high translucence in the visible light range. Optionally, at least the bone-engaging portions of an all-ceramic implant are coated with a fused layer of titanium oxide.

The present invention enables modification of an intraosseous implant device that is not only biologically non-inert, but can stimulate bone and vascular growth; decrease localized inflammation; and fight local infections. The method of the present invention provides a fiber with any of the following modifications: (1) Nanofiber with PDGF, (2) Nanofiber with PDGF+BMP2, and (3) Nanofiber with BMP2 and Ag. Nanofiber can be modified with other growth factors that have been shown to improve bone growth and maturationBMP and PDGF being the most common. Nanofiber can be applied on the surface of the implant in several ways. First, a spiral micro-notching can be applied on the implant in the same direction as the threads with the nanofibers embedded into the notches. Second, the entire surface of the implant may be coated with a mesh of nanofibers. Third, it can be a combination of both embedding and notching.

A method of manufacturing an article including taking an article in an initial state formed using an additive manufacturing process, the article including at least one set of mounting features; performing a second manufacturing process to transform the article into a second state, which includes mounting, via the at least one set of mounting features, the article in a holding device of a machine for operating on the article, wherein the position and orientation of the article in three linear and three rotational degrees of freedom within the machine operating volume is known and defined by virtue of the interaction of the mounting features with the holding device, and processing at least one feature on the article. The at least one mounting feature includes kinematic mount features which engage with corresponding kinematic mount features on the holding device of the machine.

A hybrid method for producing dental connections by sintering and milling, providing a plate (1) of known dimensions; using a sintering machine (3) having a sintering disc (2); attaching the plate (1) to the sintering disc (2) of the sintering machine (3); sintering support columns, dental connections (5) and at least one centring lug (4); providing a milling machine having an attachment support (6); movably providing the plate (1) on the attachment support (6); providing a centring shaft (10) coupled to the milling machine, which has a head (11) with sloped surfaces; positioning the plate (1) in a horizontal plane (X, Y) by moving the centring shaft (10) such that the centring shaft (10) fits closely on the centring lug (4); attaching the plate (1), once positioned in the milling machine; and milling the dental connections (5), a height reference in the vertical component (Z) being known.

A method for making a rapid prototype of a patient's mouth to be used in the design and fabrication of a dental prosthesis. The method takes an impression of a mouth including a first installation site having a dental implant installed in the first installation site and a gingival healing abutment having at least one informational marker attached to the dental implant. A stone model is prepared based on the impression, including teeth models and model markers indicative of the at least one informational marker. The model is scanned. Scan data is generated from the scanning. The scan data is transferred to a CAD program. A three-dimensional model of the installation site is created in the CAD program. The at least one informational marker is determined to gather information for manufacturing the rapid protocol. Rapid prototype dimensional information is developed. The rapid prototype dimensional information is transferred to a rapid prototyping machine which fabricate a rapid prototype of the patient's dentition as well as a dental implant analog position.