A flow control device (241, 260, 300, 350, 450, 480, 500) for a bronchial passageway including: a one-way valve (273, 313, 360, 478, 511); a hollow structural frame (242, 302, 352, 453, 468, 509) housing the one-way valve, wherein the structural frame is expandable from a collapsed configuration to an expanded configuration; and a sealing membrane (316, 470, 512) mounted to at least a distal portion of the structural frame, wherein the sealing membrane forms an enclosed wall defining at least a portion of an airflow passage through the flow control device, and the one-way valve is included in the airflow passage.

An implant (500) comprises an elastic deformation portion (51) and a connection portion (52) connected with the proximal end (511) of the elastic deformation portion (51), wherein the elastic deformation portion (51) is covered by an elastic outer layer (55); the proximal end of the connection portion (52) is surrounded by a tightening ring (58); and the proximal end of the elastic outer layer (55) is covered by the tightening ring (58). Since the proximal end of the elastic outer layer (55) of the implant (500) is surrounded by a tightening ring (58), the elastic outer layer (55) is closely attached on the connecting portion (52) of the implant (500), such that the elastic outer layer (55) can be prevented from being rolled over from the surface of the implant (500) when the implant (500) is implanted, thereby improving safety of lung volume reduction surgery.

A conveyor for an implant having at least one cavity, including a conveying handle, a conveying cable, and a core wire. The conveying cable is a tubular body, a proximal end of the core wire is connected to the conveying handle, and a distal end of the core wire penetrates a distal end of the conveying cable from a proximal end of the conveying cable; a first control is provided on the conveying handle, and when the implant is connected to the distal end of the conveying cable, the first control controls the distal end of the core wire to extend into the implant to straighten the curved implant, or the first control controls the core wire to withdraw from the implant to restore the implant to a preset shape. The conveyor can load and release the implant on the conveyor, and be used in the entire implanting process.

A lung-volume-reduction elastic implant (500) is tubular and at least the proximal end of the implant has an opening. The implant (500) comprises an elastic deforming part (51) and a flexible guiding part (53) connected to the distal end of the elastic deforming part (51). The elastic deforming part (51) has a shape memory property. The elastic deforming part (51) is provided in the lengthwise direction thereof with several slots (514) at intervals, wherein each slot (514) communicates with the tubular cavity of the elastic deforming part (51). Under the same externally applied force, the flexible guiding part (53) deforms more easily than the elastic deforming part (51). An implant delivering instrument (600) comprises an implant (500) and a matching delivering means (700). The delivering means (700) comprises a core wire (71) and a hollow pushing member (73). The implant (500) is detachably connected to the distal end of the pushing member (73) by means of the proximal end of the implant. The core wire (71) movably passes through the tubular cavity of the implant (500) and the tubular cavity of the pushing member (73).

Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region. An exemplary flow control device is configured to block fluid flow in the inspiratory direction and the expiratory direction at normal breathing pressures and allow fluid flow in the expiratory direction at higher than normal breathing pressures.

Tracheal stents may include a plurality of wave form structures each extending radially about the support structure, a plurality of axial loop members extending axially between adjacent wave form structures and a polymeric covering disposed thereover. Tracheal stents may include an expandable metal structure and a plurality of spacer fins extending above an outer surface of the expandable metal structure. The plurality of spacer fins may be formed of a material different than that of the expandable metal structure.

Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).

An airway support device of the present disclosure can be attached to tracheal and/or bronchial cartilage on opposing sides of a tracheal and/or bronchial wall to pull the tracheal and/or bronchial cartilages toward each other to reconstruct and/or reshape to a normal anatomy across the membranous tracheal and/or bronchial wall and thus relieving tension across the tracheal and/or bronchial wall. The airway support device can include at least two longitudinal strips that extend longitudinally along and are attached (e.g., sutured) to the trachea and/or bronchus on opposite sides of the tracheal and/or bronchial wall. Pairs of lateral strips extending from each of the longitudinal strips can be attached to each other under tension. The tracheal and/or bronchial wall can be attached (e.g., sutured) to the lateral strips to open the airway of the trachea and/or bronchus.

An intra-tumoral agent deployment apparatus for diagnosing and delivering targeted, sequential deployment of agents to an endo-bronchial and, or an intra-parenchymal tumor, said apparatus formed of, among other things, an elongated shaft assembly including: at least one lumen; an intra-tumoral probe wire for tumor traversal, slidably interposed there between or slidably disposed between any one of, or combination of the at least one lumen; and wherein the displacement of the intra-tumoral probe wire causes disruption of an endo-bronchial and, or an intra-parenchymal tumor tissue, and, or creating an inlet for deployment of at least a first agent comprising any one of a therapeutic agent and, or a delivery vehicle from the first lumen, and a subsequent second agent comprising any one of a therapeutic agent and, or a binding agent from any one of the first lumen, second lumen, and, or the delivery vehicle.

An endobronchial blocker for treatment of a persistent air leak, the endobronchial blocker comprising a perimeter wall, the perimeter wall comprising an exterior surface and an interior surface and enclosing a hollow internal cavity; an open end, the open end comprising a rim defining an opening to the hollow internal cavity; a closed end opposite the open end, the closed end and the perimeter wall being airtightly arranged so as to obstruct airflow into and out of the hollow internal cavity; and one or more friction enhancing elements on the exterior surface of the perimeter wall.