The present invention provides gastrointestinal devices for limiting transfer and contact of material across luminal walls along a segment of the gastrointestinal tract (e.g., at the duodenum and/or upper jejunum). Devices of the invention include a gastrointestinal sleeve, an anchor, and a flange for attachment to a luminal wall proximal to the pyloric orifice. The invention also provides methods of use associated with such gastrointestinal devices, including methods for delivery, removal, and treatment of metabolic disorders, such as type 2 diabetes, non-alcoholic steatohepatitis, non-alcoholic fatty liver disease, obesity, and related comorbidities thereof by implanting gastrointestinal devices.

Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).

The invention described herein relates to telescoping stents. The embodiments described herein allow for adequate securement to, accommodation for movement by, and prevention of injury of tubular organs or hollow areas of the body. Certain embodiments relate to telescoping steins with loop interlocking mechanisms. Further embodiments relate to telescoping stents with ball-in-groove interlocking mechanisms.

Methods, apparatuses and systems are described for delivering a stent through an access hole of a body lumen and covering up the access hole after deploying the stent, Stents are described that include a stent body defining a body lumen contact surface area and a deployable member configured to deploy from the stent body and increase the body lumen contact surface area of the stent. Deployable members that hinge, unroll, extend, expand, and coaxially translate with respect to the stent body are described. A system for delivering a stent into a body lumen are described that may include a coverage member configured to at least partially cover the hole in the wall of the stent upon withdrawing a tubular member through the hole in the wall of the stent. Coverage members may include a self-sealing membrane, a flap valve, or a hinged valve.

The present disclosure provides a kirigami-inspired injectable stent system. The stent systems and methods enable radial/circumferential and longitudinal delivery of an extended release of therapeutics within tubular structures of the body, such as the GI tract and trachea. According to some aspects, a kirigami-based injectable stent system is provided that can enable drug release through deposition of therapeutic-coated needles of the stent in the tubular mucosa, such as often found in the gastrointestinal tract or trachea.

A bypass device may include an elongate member extending from a proximal end toward a distal end, and a proximal opening and a distal opening coupled to one another by a lumen disposed through the elongate member. The bypass device also may include at least one port extending through a side surface of the elongate tubular member, wherein at least a portion of the bypass device may be bioabsorbable.

An illustrative stent may comprise an elongated tubular member having a first end and a second end and an intermediate region disposed therebetween. The elongated tubular member configured to move between a collapsed configuration and an expanded configuration. The elongated tubular member may comprise at least one twisted filament, such as a knitted filament having a plurality of twisted knit stitches with intermediate rung portions extending between adjacent twisted knit stitches, or a plurality of helical filaments twisted with a plurality of longitudinal filaments.

A medical tool for placement in a digestive tract lumen includes a tubular portion, which opens at two ends, and an annular attachment portion, which is configured to be fixed to at least a part of the tubular portion and be capable of installing the tubular portion in the digestive tract lumen. The tubular portion is placeable along the digestive tract, has a side surface that is capable of conforming to the shape of the inner wall of the digestive tract, and allows digestive juice or digested contents to permeate. The attachment portion is configured to be placeable in the stomach through the mouth.

The present disclosure is related to medical devices, stents, drainage devices, and the like, which feature a doubled back design. Various embodiments described herein have a portion with overlapping layers, at least one of which may comprise a cover.

A gastrointestinal system includes a bracelet type anchor constructed and arranged to reside in a body cavity, a gastrointestinal sleeve configured to expand under a load and contract when the load is removed and a string connecting a bracelet type anchor with the sleeve. Pulling the string transforms the bracelet type anchor from a flexible mode into a rigid state.