The present disclosure relates to a layered graft material and to implantable medical devices including such a graft material. In one embodiment, the device is a stent-graft. In other embodiments, the invention relates to methods of manufacturing and using such devices. In one embodiment the graft is formed of at least three layers, including a folded central layer.

An embodiment in accordance with the present invention provides a device and method for the treatment of urethral stricture. The present invention places and holds a graft at an incised urethral stricture site for 5-21 days, while the graft adherences to the incised urethral stricture site. A device of the present invention includes a delivery component, a graft carrier component, and a removal component. In some embodiments, the delivery and removal components may be combined into the same device. The delivery component, the graft carrier component, and the removal component are all configured to enter and exit the urethra without trauma. A method according to an embodiment of the present invention includes harvesting a graft, loading the graft onto the graft carrier component, introducing the delivery device into the urethra with the graft carrier component and graft loaded, and delivering of the graft to the incised urethral stricture site.

Urologic stents that are adapted for temporary use to provide relief following treatments for benign prostatic hyperplasia and other disorders of the prostate, urethra and ureters.

Systems, devices, and methods are provided for the delivery of an implant into the prostatic urethra. Embodiments of delivery systems can include a delivery device for insertion into the patient and a proximal control device for use in controlling release of the implant from the delivery device.

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

Devices and methods for trimming a stent to a desired length with an outer tube and an inner tube having a distal end and a diameter configured to receive a portion of the stent in excess of the desired length. The inner tube may move within the outer tube and the distal end may include an end effector configured to trim the portion from the stent while the device and stent are within a patient.

Urological (prostatic) implant, system, and method for retracting or/and supporting periurethral tissue enclosing a prostatic urethra along lengths of prostate lobes, for example, in BPH patients. Prostatic implant includes independently actuatable distal retractor incorporating craniolateral corners and proximal retractor incorporating caudolateral corners. Retractors may be connected via elongated spine member, and formed as paired curved wing-liked structures having interconnecting members. May further include tissue support members extending between elongated edge members connecting retractors to spine member, and tissue support members extending between elongated edge members and spine member. Tissue support members are sized and configured for supporting portions of prostatic lateral lobes when spine member engages anterior interlobar groove extending between prostatic lateral lobes, and when elongated edge members engage posterolateral interlobar grooves. System and method include implant manipulator detachably connected to implant elongated edge members, for manipulating and forcing implant caudolateral corners into close proximity, for delivery into subject.

A convertible nephroureteral catheter is used in the treatment of urinary system complications, particularly on the need for a single surgically delivered device to treat patients who must be seen by an interventional radiologist (IR). In many current procedures, patients need to return to the operating room to remove a previously delivered nephroureteral catheter to exchange this catheter with a fully implanted ureteral stent delivered though the same access site at the flank. The present convertible nephroureteral catheter reduces the need to return for a second surgical procedure. Two weeks after initial implantation, the proximal portion of the convertible nephroureteral catheter extending out from the body may simply be removed. A simple action at the catheter hub allows this proximal portion to be removed, leaving behind the implanted ureteral stent within the patient's urinary system. Other medical procedures, devices, and technologies may benefit from the described convertible catheter.

An example medical stent for treating a body lumen is disclosed. The example stent includes an expandable scaffold having a first end region, a second end region and an outer surface. The stent further includes a first fixation member coupled to the expandable scaffold and a biodegradable material disposed along the first fixation member at a first tissue engagement region. Further, the biodegradable material is designed to degrade from a first configuration in which the biodegradable material shields the first fixation member from a target tissue site to a second configuration in which the first fixation member is engaged with the target tissue site.

Systems, devices, and methods are provided for the delivery of an implant into the prostatic urethra. Embodiments of delivery systems can include a delivery device for insertion into the patient and a proximal control device for use in controlling release of the implant from the delivery device.