Endovascular stents and endovascular device platforms and related methods that allow for the modulation/regulation of vascular flow to treat certain disease states are provided. In particular, a covered endovascular stent is provided that, upon deployment, is configured to an installed shape. A balloon catheter comprising a stem and an angioplasty balloon on an end of the stem can be provided to expand the stent. The angioplasty balloon can have a dumbbell shape when inflated with a first head on a first end of the angioplasty balloon having a first outer diameter and a second head on a second end of the angioplasty balloon having a second outer diameter and a narrow center portion having a third outer diameter that is less than the first outer diameter of the first end and the second outer diameter of the second end of the angioplasty balloon. Thereby, the covered stent configured in the installed shape can comprise a dumbbell shaped tubular structure having a first inner diameter of a first end portion and a second inner diameter of a second end portion that are larger than a third inner diameter within a center portion of the tubular structure.

A system for preventing thrombosis in an implantable medical device includes an implantable medical device sized for implantation at least partially within a patient's body. The device includes an at least partially electrically conductive portion that is disposed within a patient's body upon implantation, an electrode coupled to the electrically conductive portion of the device; and a power source coupled to the electrode. The power source provides a negative electric charge to the at least partially electrically conductive portion for an indefinite period of time. The device may be configured to resist thrombosis, infection, and/or undesired tissue growth via the charged conductive portion once implanted. Exemplary embodiments of the implantable medical device include a hemodialysis vasculature graft, a dialysis catheter, a coronary artery, and a heart valve.

A system for preventing thrombosis in an implantable medical device includes an implantable medical device sized for implantation at least partially within a patient's body. The device includes an at least partially electrically conductive portion that is disposed within a patient's body upon implantation, an electrode coupled to the electrically conductive portion of the device; and a power source coupled to the electrode. The power source provides a negative electric charge to the at least partially electrically conductive portion for an indefinite period of time. The device may be configured to resist thrombosis, infection, and/or undesired tissue growth via the charged conductive portion once implanted. Exemplary embodiments of the implantable medical device include a hemodialysis vasculature graft, a dialysis catheter, a coronary artery, and a heart valve.

The present invention provides systems and methods for deploying implantable devices within the body. The delivery and deployment systems include at least one catheter or an assembly of catheters for selectively positioning the lumens of the implant to within target vessels. Various deployment and attachment mechanisms are provided for selectively deploying the implants.

The invention relates to an endoprosthesis (1), in particular a vascular stent or a heart stent, comprising at least one body (3) part. At least one area (5,6) of an outer surface, preferably the whole outer surface, of the at least one body part (3) is provided with thrombogenic fibers (2). The invention further relates to methods of manufacturing endoprostheses (1).

A vascular prosthesis configured to be implanted in a vessel, having substantially a T-shape, comprises a proximal tubular part forming the base of the “T” and a distal tubular part forming the head of the “T”. The proximal tubular part has a first lumen, the distal tubular part has a second lumen, and the first and second lumens are fluidly connected to form a common lumen. The distal tubular part comprises a first end portion, a second end portion, and an intermediate portion extending axially between the first and second end portions. The first and second end portions are radially expandable. The proximal tubular part is connected to the intermediate portion and the second end portion is movable between a retracted position in which the second end portion is axially restrained and a deployed position in which the second end portion is axially deployed.

A device and method for diverting a portion of oxygenated blood from a lower pressure region, e.g., left atrium or pulmonary vein, and providing it to the aorta, bypassing the left ventricle, operating at least in part, on the Venturi effect. The device includes a first conduit that diverts a portion of blood from the aorta to a parallel flow path. The device includes a second conduit that delivers blood from the lower pressure region to the first conduit. The blood from the lower pressure region in the second conduit is combined with the blood from the aorta in the first conduit and returned to the aorta. The second conduit is coupled to the first conduit at or near a narrow segment of the first conduit. A Venturi effect at or near the narrow segment draws the blood from the lower pressure region into the first and/or second conduit.

A device and method for diverting a portion of oxygenated blood from a lower pressure region, e.g., left atrium or pulmonary vein, and providing it to the aorta, bypassing the left ventricle, operating at least in part, on the Venturi effect. The device includes a first conduit that diverts a portion of blood from the aorta to a parallel flow path. The device includes a second conduit that delivers blood from the lower pressure region to the first conduit. The blood from the lower pressure region in the second conduit is combined with the blood from the aorta in the first conduit and returned to the aorta. The second conduit is coupled to the first conduit at or near a narrow segment of the first conduit. A Venturi effect at or near the narrow segment draws the blood from the lower pressure region into the first and/or second conduit.

Methods of producing hybrid fibrous scaffolds are provided. The methods include dissolving a polymer, such as polydioxanone, in a solution, such as 1,1,1,3,3,3-hexafluoro-2-propanol (HFP), to form a polymer-containing solution. The method comprises electrically charging the polymer-containing solution. The method comprises writing the polymer-containing solution on a counter electrode or a ground in a grid pattern to form semi-stable fibers comprised of the polymer, the semi-stable fibers vary between bent and straight and forming the hybrid fibrous scaffold. The writing may be performed by a 3D printer. The resulting scaffolds and methods of using the same are also disclosed herein.

Methods of producing hybrid fibrous scaffolds are provided. The methods include dissolving a polymer, such as polydioxanone, in a solution, such as 1,1,1,3,3,3-hexafluoro-2-propanol (HFP), to form a polymer-containing solution. The method comprises electrically charging the polymer-containing solution. The method comprises writing the polymer-containing solution on a counter electrode or a ground in a grid pattern to form semi-stable fibers comprised of the polymer, the semi-stable fibers vary between bent and straight and forming the hybrid fibrous scaffold. The writing may be performed by a 3D printer. The resulting scaffolds and methods of using the same are also disclosed herein.