A biocompatible structure includes one or more base structures for regeneration of different tissues. Each base structure includes alternately stacked polymer layers and spacer layers. The polymer layer includes a polymer and tissue forming nanoparticles. The polymer includes polyurethane. The tissue forming nanoparticles includes hydroxypatites (HAP) nanoparticles, polymeric nanoparticles, or nanofibers. The spacer layer includes bone particles, polymeric nanoparticles, or nanofibers. The weight percentage of tissue forming nanoparticles to the polymer in the polymer layer in one base structure is different from that in the other base structures. A method of producing the biocompatible structure includes forming multiple base structures stacked together, coating the stacked multiple base structures, and plasma treating the coated structure.

A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c) optionally but preferably maintaining the support in a substantially static position during a second time period; and then (d) repeating steps (b) and (c) for a number of times sufficient to enhance the functionality of the tissue formed on the support and/or produce organized skeletal muscle tissue on the solid support from the precursor muscle cells.

A corrective device for the positioning of a foot is an apparatus used to treat foot drop. The apparatus includes a spring, a bone anchor assembly, and a tendon anchor assembly. The spring is used to prevent the foot from drooping downward. The spring includes a coil, a first spring coupler, and a second spring coupler. The first spring coupler is used to connect the coil to the bone anchor assembly. The bone anchor assembly anchors the apparatus to a human tibia. The second spring coupler is used to connect the coil to the tendon anchor assembly. The tendon anchor assembly is used to anchor the apparatus to one or more tendons in the foot. Because the coil is anchored above and below the ankle, rotations about the ankle may be limited by the coil.

Implants are provided, comprising the implant and a plurality of sensors. Briefly stated, implants (also sometimes referred to as devices or medical devices) are provided comprising an implant along with one or more sensors to monitor the integrity, position and efficaciousness of the implant. The sensors may be positioned on the inside of the implant, within the body of the implant, or on the outer surface (or surfaces) of the implant, and/or between the implant and any device that might be utilized to deliver the implant (e.g., another implant, catheter, tunneling catheter, endoscope, balloon implant, or other medical device).

Provided herein is an artificial muscle capable of being miniaturized, realizing precision movement, and performing selective relaxation/contraction deformation according to the power output necessary in the muscle, the muscle including a first operation unit that includes electro-active polymer where relaxation-deformation occurs based on electric energy being applied; a heating unit that generates heat energy based on the electric being applied; a second operation unit that has a yarn structure and where contraction-deformation occurs based on the heat energy generated in the heating unit; and a control unit that applies electric energy to the first operation unit and the heating unit.

Provided herein are methods of culturing organized skeletal muscle tissue from precursor muscle cells by cyclically stretching and relaxing said muscle cells on a support in vitro for a time sufficient to produce said organized skeletal muscle tissue, including reseeding said organized skeletal muscle tissue by contacting additional precursor muscle cells to said organized skeletal muscle tissue on said solid support, and then repeating said step of cyclically stretching and relaxing said muscle cells in said support in vitro for time sufficient to enhance the density (i.e., increased number of nuclei and/or number of multinucleated cells) of said organized skeletal muscle tissue on said support.

A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c) optionally but preferably maintaining the support in a substantially static position during a second time period; and then (d) repeating steps (b) and (c) for a number of times sufficient to enhance the functionality of the tissue formed on the support and/or produce organized skeletal muscle tissue on the solid support from the precursor muscle cells.

The present invention provides an actuator, comprising a fiber and a temperature regulator capable of at least one of heating and cooling the fiber. The fiber is twisted around a longitudinal axis thereof. The fiber is folded so as to have a shape of a cylindrical coil. The fiber is formed of linear low-density polyethylene. The following mathematical formula (I) is satisfied: D/d<1 (I), where D represents a mean diameter of the cylindrical coil; and d represents a diameter of the fiber.

Provided herein are methods of culturing organized skeletal muscle tissue from precursor muscle cells by cyclically stretching and relaxing said muscle cells on a support in vitro for a time sufficient to produce said organized skeletal muscle tissue, including reseeding said organized skeletal muscle tissue by contacting additional precursor muscle cells to said organized skeletal muscle tissue on said solid support, and then repeating said step of cyclically stretching and relaxing said muscle cells in said support in vitro for time sufficient to enhance the density (i.e., increased number of nuclei and/or number of multinucleated cells) of said organized skeletal muscle tissue on said support.

Described herein are intra-oral prostheses that can help replace or augment the function of the native tongue, such as to assist with swallowing. Disclosed prostheses can provide mechanical force, based on the power of mastication, to propel a food bolus into the pharyngeal phase of swallowing. Disclosed prostheses can be used to enhance swallowing rehabilitation as a temporary aid and/or can be used to permanently replace lost tongue functionality. Also disclosed are other anatomical prostheses, such as to provide power for the articulation of dysfunctional extremities, by transforming mechanical force from another nearby functioning muscle group.