A Descemet Membrane Endothelial Keratoplasty (DMEK) holder for placement within a vial for supporting a corneal tissue inserter is provided. The DMEK holder includes a top and an opposite bottom, at least one support member extending between the top and the bottom, with a bottom portion of the at least one support member sized and shaped to fit against a bottom inner surface of the vial to thereby support the corneal tissue inserter within the vial, and a first annular member having an opening sized and shaped such that a bottom end of the corneal tissue inserter is insertable through the opening and the first annular member separates the corneal tissue inserter from an inner surface of the vial and positions the corneal tissue inserter within the vial away from inner surfaces of the vial to thereby improve retrieval of the corneal tissue inserter by a surgeon.

This disclosure describes methods of preparing a decellularized Descemet's membrane and an isolated Descemet's membrane, methods of using an isolated Descemet's membrane, and tissues prepared using an isolated Descemet's membrane. This disclosure further describes a composition that includes an isolated Descemet's membrane. In some embodiments, the tissues and methods described herein may be used to treat a limbal stem cell deficiency or as an ocular surface bandage.

A device (1) for eye surgery includes a metallic ring (2) for suturing to the sclera of a patient's eye. A locking element (3) can be coupled to the metallic ring (2). The locking element (3) includes a lens (31) and a coupling ring (32) fixed to the lens (31) along the entire circumference of the inner edge of the lens (31). The coupling ring (32) is configured for coupling to the metallic ring (2).

A corneal implant injector system includes an injector including a plunger slidable in a plunger housing, and a distal cartridge grabbing member engageable with an implant-holding cartridge.

The invention provides keratoprosthesis devices and kits and surgical methods of their use.

The invention provides a device for secure support, storage and/or transport of a tissue graft or an implant, which allows for precise microscopic investigation and/or evaluation and quality control of the tissue graft or implant during processing as well as prior to introduction into a living body. The main body of the device is a cannula or a cartridge comprising rectangular shape, preferably with rounded edges, having two opposite openings of different sizes and shapes. The first opening has a round shape with a diameter suitable for connection to a tube or a syringe nozzle. The second opening has an elliptical, round, biconvex or rectangle shape, in the latter case preferably with rounded edges that is small enough to be inserted into a small surgical incision. The transparency and preferably rounded, rectangular shape of the main body of the device permits microscopic examination of the tissue graft or implant within the device, as well as secures the tissue graft or implant position during delivery and implantation. The elliptical, round, biconvex or preferably rounded rectangle inner shape of the second opening ensures the correct positioning of the tissue graft or implant during surgical implantation, thereby preventing issues such as loss of the tissue graft or implant orientation. The invention further provides assemblies for loading, storing and/or transporting a tissue graft or implant comprising the device according to the invention. The invention further provides a washing assembly and a method for preparing a tissue graft or implant.

Provided is a storage container for storing a cornea specimen in which an endothelium and an epithelium of a cornea can be immersed and stored in different storage solutions. The storage container 1A is provided with a specimen-supporting portion 3A which contains a first cornea exposure portion 31a and a second cornea exposure portion 31b that expose a cornea part 101, the specimen-supporting portion supporting a scleral rim 102 at an outer circumferential side of the first and second cornea exposure portions 31a, 31b; a first chamber 20a to which an endothelium side of the cornea part 101 in the cornea specimen 100 is exposed, the scleral rim 102 of the cornea specimen 100 being supported by the specimen-supporting portion 3A, and the first chamber containing a first storage solution 60a; and a second chamber 20b to which an epithelium side of the cornea part 101 in the cornea specimen 100 is exposed, the scleral rim 102 of the cornea specimen 100 being supported by the specimen-supporting portion, the second chamber being divided from the first chamber 20a by the specimen-supporting portion 3A, and the second chamber containing a second storage solution 60b that differs from the first storage solution 60a, wherein the storage container is configured to prevent the first and second storage solutions 60a, 60b from being circulated between the first and second chambers 20a, 20b.

Assemblies for storing, handling, transporting, viewing, evaluating, and/or shipping corneal tissue are provided. The assembly includes a corneal tissue carrier, optimized for DSAEK and UT-DSAEK corneal grafts, within a transport vial, the transport vial removably coupled to a stabilization base, wherein the ease of access to the graft carrier allows administering the corneal tissue sample to a patient in rapid succession so that more surgeries can be performed by a single surgeon in a single day.

A surgical device for implanting an artificial cornea into an eye can comprise an installation tool comprising an implantation end for receiving a back portion of an artificial cornea. The installation tool can further comprise a drive nut positioned above the implantation end. The surgical device can further comprise a thumbscrew that is received within the drive nut. The thumbscrew can be rotatable relative to the drive nut to adjust a position of the thumbscrew. During an implantation procedure, the implantation end with the back portion of the artificial cornea positioned thereon can be inserted into the eye, and the thumbscrew can be rotated relative to the drive nut to interact against a front portion of the artificial cornea to lock the artificial cornea in place.

A single-use adjustable depth trephine corneal punch device that allows a goal trephination depth of a donor cornea to be set and cut prior to a surgical procedure for cutting selected portions of an actual patient cornea. The corneal punch includes a punch block having a central well for receiving a donor cornea, a punch top mounted atop the punch block and having a central cylindrical opening coaxially aligned with the well, a punch blade mounted atop the punch top and through the opening cooperates with the top for combined limited rotation and limited axial movement from a reference or “start” point and into juxtaposed relation against the cornea and a limited axial downward movement during rotation to make a shallow cut in the cornea.