Medical kits and methods for performing small incision DLEK include a corneal transplantation donor tissue graft formed into an implantable and compact rolled configuration using the flexible substrate.

An eye enlargement implant and a method of performing a cosmetic procedure for the beauty of eyes, which is capable of being inserted into the eyes so as to make the eye look crisper and bigger, and being removed when it is not necessary without causing eye inflammation and without having to be replaced, the implant including a ring-shaped body which is inserted between a sclera and a conjunctiva of an eyeball having an inner diameter portion having at least a size enough to surround an outer periphery of the cornea, and an outer diameter portion having a width size of 0.8 to 1.2 mm so as to cover a white portion and having a maximum thickness of 0.05 to 0.20 mm at the center portion, where the ring-shaped body has flexibility and a predetermined color which is similar to that of the iris.

A method of corneal transplantation with cross-linking following implantation of a corneal graft is disclosed herein. The method includes the steps of: (i) removing a diseased central portion of a host cornea from an eye of a patient; (ii) implanting a corneal graft into the eye of the patient in a location previously occupied by the diseased central portion of the host cornea; and (iii) cross-linking a peripheral portion of the host cornea and the corneal graft after implanting the corneal graft so as to prevent an immune response to the corneal graft and to prevent a rejection of the corneal graft by the patient. A method of corneal transplantation with cross-linking following implantation of a corneal inlay is also disclosed herein. Also, methods disclosed herein utilize nanoparticles, antibody-coated nanoparticles, and cell penetrating agents to enhance the penetration of a photosensitizer in the cornea of a patient.

A surgical tool assembly is disclosed. The surgical tool assembly includes a forceps instrument including a proximal handle portion with an actuator, and a distal forceps portion including jaws. The actuator selectively moves the jaws. The surgical tool assembly includes an infusion assembly including a tube configured to be connected to a fluid source at a primary tube end and connected to a fitting at a paracentesis tube end. The fitting defines a passage configured to receive the distal forceps portion of the forceps instrument. An infusion sleeve extends away from the fitting. The infusion sleeve is arranged concentric around an outer surface of the distal forceps portion to define a fluid pathway. The jaws extend beyond a terminal end of the infusion sleeve such that the jaws are arranged outside of the infusion sleeve.

Disclosed is a delivery system for an ocular implant and a method of delivering an ocular implant to an eye using a delivery system. The delivery system includes a delivery tube having a delivery end and a control end, and the delivery end comprises an opening. A delivery device is configured to fit at least partially within the delivery tube. The delivery device configured to contact the ocular implant and control the position of the ocular implant within the delivery tube. The delivery system includes a fluid inlet nozzle that is configured to inject fluid into the delivery tube between the control end and the ocular implant. The delivery system is configured such that the injected fluid flows around the sides of the ocular implant and out from the delivery end of the delivery tube.

An injector of intracorneal segments has a disposable segment holding head comprising a lancet (36) formed with a housing closed by the lid (37) wherein a sterilized corneal segment (11) is housed, behind which there is a needle (26) longitudinally slidable under the action of a trigger (31) and a spring (32). The head also has a manual selector (38) to deflect the needle to place the segment at 90 of the head to the right or left of a channel made in the cornea for injection. The segment pre-installed in the head is provided with recesses formed by knurling (16) on its outer chord (14) where it couples to the needle for the push.

The present invention provides an insertion tool for inserting an implant, said implant having an implant lower side and an implant upper side, said implant upper side comprising cells, said insertion tool comprising: an implant carrier configured to hold said implant; and a body having at least two configurations, a first body configuration with said implant carrier at least partially contained within said body and said implant held by said implant carrier and a second body configuration with said implant carrier outside said body; said implant carrier is configured to maintain a position of the implant and a shape of the implant and functionality of said cells during such time as the implant carrier is contained by said body, and during an implantation procedure.

A device for manipulating an implant includes a handle coupled to a guide extending from the handle to a distal end. The device includes an engagement mechanism disposed at the distal end of the guide and configured to engage an implant. The device includes a first actuator disposed on the handle and coupled to the engagement mechanism. The first actuator causes the engagement mechanism to engage the implant. The device includes an air chamber disposed in an interior chamber of the handle and configured to hold air. The device includes a lumen coupled to the air chamber and extending along the guide to the distal end. The lumen includes an air channel extending through the lumen. The device includes a second actuator disposed on the handle. The second actuator causes the air chamber to deliver the air, via the air channel, to the distal end.

There is disclosed a surgical device comprising a handle (14) for releasable attachment to a cartridge (1) adapted to hold an endothelial corneal implant in a scrolled or double coiled configuration. The handle has a forward end for releasable attachment to the cartridge, a rearward end and a gripping portion (60) between said forward and rearward ends. The gripping portion is substantially planar so as to facilitate being gripped between finger and thumb. The handle incorporates a first flexible fluid conduit (61) for releasable fluid connection to the cartridge at the forward end of the handle. There is further disclosed a surgical device comprising a handle having a forward end and a rearward end and a gripping portion between said forward and rearward ends. The gripping portion is substantially planar so as to facilitate being gripped between finger and thumb. The surgical device also comprises a cartridge having a forward end, a rearward end and a hollow interior that is open at the forward and rearward ends, the rearward end for releasable attachment to the forward end of the handle, and the hollow interior of the cartridge adapted to hold an endothelial corneal implant in a scrolled or double coiled configuration. In addition, the surgical device comprises a first flexible fluid conduit incorporated in the handle, wherein the first flexible fluid conduit is configured for releasable fluid connection to the rearward end of the cartridge at the forward end of the handle.

A graft injector assembly includes a coating disposed on an interior surface of an injector body to form a lumen. The lumen is structured to store a graft comprising corneal tissue and to allow the graft to exit distally from the injector body, preferably with minimal or no damage to the corneal tissue. The corneal tissue may include a Descemet membrane and endothelial cells, which may be used in Descemet Membrane Endothelial Keratoplasty (DMEK). In one example, the assembly includes an organosilane coating disposed on a glass injector body.