A mask is provided that is configured to increase the depth of focus of a patient. The mask can include an aperture configured to transmit along an optical axis substantially all visible incident light. The mask can further include a portion surrounding at least a portion of the aperture. The portion may be configured to be substantially opaque to visible electromagnetic radiation and be substantially transparent to electromagnetic radiation transmitted from an ocular examination device (e.g., substantially transparent to at least some non-visible electromagnetic radiation with a wavelength between about 750 nm and about 1500 nm).

Provided are an artificial cornea having sufficient strength and optical properties, in which deviation or infection of the artificial cornea is restrained, and a method for manufacturing the artificial cornea. According to the present invention, the method for manufacturing the artificial cornea includes a nonwoven fabric preparation step of preparing a nonwoven fabric formed therein with a through-hole, and a gel arrangement step of arranging an aqueous polymer gel to cover the through-hole.

Devices, methods and kits are described for reducing intraocular pressure. The devices include a support that is implantable within Schlemm's canal and that may restore or maintain at least partial patency of the canal without substantially interfering with transmural or transluminal fluid flow across the canal. The devices utilize the natural drainage process of the eye and may be implanted with minimal trauma to the eye. Kits may include a support and an introducer for implanting the support within Schlemm's canal. Methods may include implanting a support within Schlemm's canal, where the support is capable of restoring or maintaining at least partial patency of the canal without substantial interference with transmural or transluminal fluid flow across the canal.

A method and delivery system are disclosed for creating an aqueous flow pathway in the trabecular meshwork, juxtacanalicular trabecular meshwork and Schlemm's canal of an eye for reducing elevated intraocular pressure. Pulsed laser radiation is delivered from the distal end of a fiber-optic probe sufficient to cause photoablation of selected portions of the trabecular meshwork, the juxtacanalicular trabecular meshwork and an inner wall of Schlemm's canal in the target site. The fiber-optic probe may be advanced so as to create an aperture in the inner wall of Schlemm's canal in which fluid from the anterior chamber of the eye flows. The method and delivery system may further be used on any tissue types in the body.

The present disclosure provides intraocular artificial lenses having a variable optical strength and methods of treating an eye disorder, such as presbyopia, using same. In some embodiments, the intraocular artificial lens comprises two optical elements that are moveable along the optical axis in relation to each other, for example in response to the accommodative process of the eye.

Implantable corneal and intraocular implants such as a mask are provided. The mask can improve the vision of a patient, such as by being configured to increase the depth of focus of an eye of a patient. The mask can include an aperture configured to transmit along an optical axis substantially all visible incident light. The mask can further include a transition portion that surrounds at least a portion of the aperture. This portion can be configured to switch from one level of opacity to another level of opacity through the use of a controllably variable absorbance feature such as a switchable photochromic chromophore within a polymer matrix.

A mask is provided that is configured to increase the depth of focus of a patient. The mask can include an aperture configured to transmit along an optical axis substantially all visible incident light. The mask can further include a portion surrounding at least a portion of the aperture. The portion may be configured to be substantially opaque to visible electromagnetic radiation and be substantially transparent to electromagnetic radiation transmitted from an ocular examination device (e.g., substantially transparent to at least some non-visible electromagnetic radiation with a wavelength between about 750 nm and about 1500 nm).

An ophthalmological implant includes a main structure with a central aperture, a first side, and a second side arranged opposite the first side. It further includes a plurality of pigment arrangements arranged in the main structure, at least one of the pigment arrangements includes at least one color pigment and an enclosure that encloses at least most of the at least one color pigment.

A method of corneal transplantation with cross-linking following implantation of a corneal graft is disclosed herein. The method includes the steps of: (i) removing a diseased central portion of a host cornea from an eye of a patient; (ii) implanting a corneal graft into the eye of the patient in a location previously occupied by the diseased central portion of the host cornea; and (iii) cross-linking a peripheral portion of the host cornea and the corneal graft after implanting the corneal graft so as to prevent an immune response to the corneal graft and to prevent a rejection of the corneal graft by the patient. A method of corneal transplantation with cross-linking following implantation of a corneal inlay is also disclosed herein. Also, methods disclosed herein utilize nanoparticles, antibody-coated nanoparticles, and cell penetrating agents to enhance the penetration of a photosensitizer in the cornea of a patient.

A scleral lens for correction of keratoconus and/or presbyopia is disclosed herein. The scleral lens includes a lens body for providing vision correction for a patient, the lens body having a central virtual pinhole, and a peripheral portion of the lens body configured to rest against a sclera of an eye such that a cavity is defined between a posterior surface of the lens body and an anterior surface of a cornea of the eye. The lens body is formed from a substantially transparent material and the central virtual pinhole includes a darkened perimeter, and the darkened perimeter of the central virtual pinhole includes a darkened internal wall extending through the lens body.