Described herein are methods and devices for delivering a drug to the frontal sinus system. An inflatable implant is positioned within the frontal sinus system using an anchoring means secured within the frontal sinus cavity. A drug-containing fluid is released directly into the frontal sinus drainage system.

A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.

A device for shaping tissue includes a tip with an internal close-looped circulation system. The tip is configured to connect to tubes. One tube is configured to connect to a submersible cold-water pump. Another tube is an outlet. The tip has a sapphire window on one face and, on opposite face, a shaft with a laser fiber therein, and an opening for laser beam to shine through.

Nasal implant obtained by additive manufacturing, comprising a main portion and a return portion connected by an intermediate portion, the main and return portions forming an angle of between 25° and 90°, said implant is made from a biocompatible ceramic of synthetic origin; said implant has an average macroporosity characterized by: a density of material of between 20% and 95% by volume, said density of material being higher in said intermediate portion than in said main portion; cavities defining sections of cavities, said sections of cavities each having a diameter of between 0.3 mm and 1 mm; said sections of cavities each having an area and a form substantially equal over the entire implant.

An accurate and precise surgical guide for dental procedures, especially a procedure involving a subject with few or no teeth as well as methods for making and use of such guides.

An implant that has a central body or core that functions as a spine, with extending articulating segments that extend from the spine. The articulating segments define a space between each section to allow the implant to be compressed and bent, such that the space between each section can be compressed or expanded. A specific use for the implant is as a sinus implant. Specific embodiments of the implant are useful in correcting missing tissue in the inferior turbinate. Specific embodiments are sized and shaped to treat empty nose syndrome (ENS). Embodiments also relate to an implant that has a port for allowing various fluids or solutions to be flushed into the implant and released through the implant surface.

Implants with fillable reservoirs have been developed that are suitable for rhinoplasty, breast reconstruction, ear reconstruction, and replacement, reconstruction or repair of other soft tissues. The implants can be filled with graft material prior to implantation. The implants are preferably made from resorbable polymers, can be tailored to provide different geometries, mechanical properties and resorption rates in order to provide more consistent surgical outcomes. The implants preferably have an interconnected network of unit cells with microporous outer layers and optionally some or all of the unit cells having at least one macropore in their outer layers. The implants can be loaded by injection with microfat, collagen, DCF, cells, bioactive agents, and other augmentation materials, prior to implantation.

Proposed is a nasal implant design method of manufacturing a patient-customized nasal implant; the nasal implant design method including: (a) acquiring a medical image of a patient's nasal portion; (b) automatically realizing a three-dimensional volume rendering image, including the skin, the bones, and the cartilage of a nasal portion, from the medical image of the patient's nasal portion on the basis of nasal cartilage data learned through artificial intelligence; (c) simulating the nasal cartilage with the three-dimensional volume rendering image in such a manner as to be suitable for a patient; (d) stably nesting a nasal implant selected from an imaginary nasal implant model database on the simulated nasal cartilage and a nasal bones; and (e) simulating the stably nested nasal implant and designing a patient-customized nasal implant in such a manner as to be suitable for the patient.

Nasal implants and nasal implant delivery tools are described herein. The nasal implants and tools can be used to deliver the implant in a minimally invasive way. The delivery tools can be adapted to separate the upper lateral cartilage from the septum and to place an implant between the septum and the upper lateral cartilage. The implant can be configured to be placed between the upper lateral cartilage and the septum. The implant system can include a first longitudinal body adapted to engage with upper lateral cartilage and the septum on a first side of the septum and a second longitudinal body adapted to engage with upper lateral cartilage and the septum on a second side of the septum.

A method and device for non-surgically repairing and augmenting internal nasal valve ligaments of a patient. The method and device comprise tunneling a working device subcutaneously into the ligaments of the nasal valve and the surrounding soft tissues and periosteum of the adjacent bony structures, causing a tightening of the nasal valve ligaments and repositioning the nasal valve in adjustable fashion. A device comprising a barbed elongate implant is introduced by tunneling subcutaneously into the nasal valve ligament allowing for structural re-positioning of the nasal valve cartilage structures and tightening of the ligaments, which is adjustable intra-operatively and allows for structural support of the nose and/or causes a change in the external shape of the nose.