The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 μm, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 μm, and having a surface area percentage of micropores in a range of 10-40%.

A universal low-profile intercranial assembly includes a mounting plate and a low profile intercranial device composed of a static cranial implant and an interdigitating functional neurosurgical implant. The low profile intercranial device is shaped and dimensioned for mounted to the mounting plate.

A device for delivering a bone material to a surgical site is provided. The device comprises a body having an upper portion and a lower portion. The lower portion of the body is substantially transverse to the upper portion and has an opening for receiving a bone material. An internal chamber is disposed within the upper portion and the lower portion, and a plunger is slidably disposed in at least the internal chamber of the body. The plunger has a distal end configured for delivering the bone material out of the lower portion of the body, wherein movement of the plunger in a first position toward the lower portion of the body delivers the bone material from the lower portion of the body to the surgical site. Methods of delivering the bone material are also provided.

A graft cage includes cross-sectional portions and longitudinal members. Each portion includes base transverse members forming a cage base; a first arm including first arm transverse members; a second arm including second arm transverse members; base connecting struts, each base connecting strut extending between first one and second one of the base members; first arm connecting struts, each first arm connecting strut extending between a first one of the first members and a second one of the first members; and second arm connecting struts, each second arm connecting strut extending between first one and second one of the second members. The longitudinal members connect the portions to one another. Intersections of the portions with the longitudinal members forming pores in the first and second arms. The pores receive an arm tip of a further graft cage therein to interlock the cage with the further cage.

A particle comprising hydroxyapatite, β-tricalcium phosphate, α-tricalcium phosphate, and/or bioactive glass is provided. The particle can be useful in bone graft compositions further comprising a carrier. The composition can include a quadphasic particle having hydroxyapatite, β-tricalcium phosphate, α-tricalcium phosphate, bioactive glass, and a carrier. The particle can have a size in the range of 50 microns to 2.5 mm. A method of repairing a bone defect is also provided. The method can include a step of applying the bone graft composition to a subject having the bone defect, such as a spinal bone defect. The subject receiving the bone graft composition can be a mammal, namely a human, pet, or domestic animal.

Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.

A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.

A bone fusion device provides stability to bones during a bone fusion period. The bones include, for example, the vertebrae of a spinal column. The bone fusion device comprises one or more extendable tabs attached to the bone fusion device by associated rotating means. The bone fusion device is preferably inserted by using an arthroscopic surgical procedure. During arthroscopic insertion of the device, the tabs are pre-configured for compactness. In this compact configuration, the tabs are preferably deposed along and/or within an exterior surface of the bone fusion device. After the bone fusion device has been positioned between the bones, one or more tab(s) are extended. In the preferred embodiment, the position of each tab is related to a positioning element and extending blocks. Typically, the tabs advantageously position and brace the bone fusion device in the confined space between the bones until the bones have fused.

Devices and methods for treating one or more damaged, diseased, or traumatized portions of the spine, including intervertebral discs, to reduce or eliminate associated back pain. In one or more embodiments, the present invention relates to an expandable interbody spacer. The expandable interbody spacer may comprise a first jointed arm comprising a plurality of links pivotally coupled end to end. The expandable interbody spacer further may comprise a second jointed arm comprising a plurality of links pivotally coupled end to end. The first jointed arm and the second jointed arm may be interconnected at a proximal end of the expandable interbody spacer. The first jointed arm and the second jointed arm may be interconnected at a distal end of the expandable interbody spacer.

A method for treating joint pain in a subject is disclosed. The method can include inserting a bone dowel and a first portion of a bone marrow aspirate into a subchondral region of a bone that is part of a joint being treated and introducing a second portion of the bone marrow aspirate into the intraarticular space of the joint being treated.