Patient-specific craniofacial implants structured for filling bone voids or planned bone voids in the cranium and face as well as for simultaneously providing soft tissue reconstruction and/or augmentation for improved aesthetic symmetry and appearance of face and skull. Pterional or temporal voids or defects generally result from a chronic skull or lateral facial deformity along with a compromised temporalis muscle or soft tissue distortion from previous surgery. When muscle and fat atrophy occurs in the pterion or temporal face, temporal hollowing deformity generally results where there would be soft tissue but for the atrophy. The patient-specific craniofacial implants with dual-purpose herein are configured to have an augmented region adjacent the temporal region of the face and cranium in order to prevent and/or correct any such temporal hollowing deformity and to utilize this newfound space to strategically embed implantable neurotechnologies for improved outcomes.

A cranial implant for access to a cerebral cortex includes a window member shaped and dimensioned for positioning within a dural defect to provide access through the dura such that access to the cerebral cortex is provided in a location under study. An implant body is provided having a geometry that substantially conforms to a resected portion of a patient's anatomy to which the implant body is to be secured.

A perfusion bioreactor system has an inner chamber and scaffold with matching porosities to equalize fluid flow through a bioreactor. The scaffold can be fabricated using additive manufacturing or other fabrication techniques to match the geometrical shape of a defect, such as a facial bone anomaly. The inner chamber is fabricated in a similar manner and has an inner cavity matching the shape of the scaffold to create a unified structure when assembled together with the scaffold. By matching the shapes of the scaffold and inner chamber, free space is eliminated within the interior volume of the bioreactor. Stem cells can be flowed through the bioreactor and attached to the scaffold, which are then cultured to grow a tissue graft.

The present disclosure relates to methods of; non-transitory, computer-readable media for; and systems for fabricating or modifying an implant. One example embodiment includes a method. The method includes registering a plurality of intraoperative locations of a surgically resected anatomical region of a patient. The method also includes generating, based on the registered plurality of intraoperative locations, a two-dimensional representation of the registered plurality of intraoperative locations. Further, the method includes determining, based on the two-dimensional representation, a two-dimensional shape of an anatomical feature excised from the surgically resected anatomical region. In addition, the method includes determining, based on the two-dimensional shape of the anatomical feature and a three-dimensional model of a portion of the patient that contains the surgically resected anatomical region, a three-dimensional shape of the anatomical feature. Still further, the method includes fabricating or modifying an implant based on the three-dimensional shape of the anatomical feature.

An intracranial prosthesis comprised of a flat body having an interior ultrasound-compatible window and a ring having a plurality of access ports about the outer portion capable of engaging a plurality of diagnostic instruments and/or intracranial delivery systems so that a practicing medical professional can monitor certain parameters of a patient or deliver therapeutic agents to the patient while using an ultrasound-monitoring device to image the patient's brain. The prosthesis is designed to allow for the continuous, uninterrupted, simultaneous monitoring of a number of parameters of a patient's brain at the patient's bedside.

Provided herein is a clip type cranial flap closing and anchoring device having a single structure including first part in contact with top surface of the flap and second part in contact with bottom surface of said flap maintaining a gap therebetween to accommodate the flap, wherein the first part is fixedly secured to third part for fastening the device to the skull.

In a three-dimensional implant and a method for manufacturing the three-dimensional implant, the three-dimensional implant is manufactured based on an image on a defect area of a skull. The image is generated based on a computed tomography on the skull of a patient. The three-dimensional implant includes a body portion, an extended portion and a fixing portion. The body portion has a shape substantially same as the defect area of the skull. The extended portion is disposed at a front of the body portion, is fixed to a zygomaticofrontal suture of the patient, and has a thickness larger than that of the body portion. The fixing portion is protruded along an outline of the body portion and is fixed with the skull.

A bone implant for enclosing bone material is provided. The bone implant comprises a covering, which can be a biodegradable mesh. The covering is configured to be rolled into a diameter to at least partially enclose the bone material within the covering. In some embodiments, the covering also includes a closure member, the closure member configured to hold the covering in a rolled configuration to a predetermined diameter to at least partially enclose the bone material. A kit and a method of using the bone implant are also provided.

A bone implant for enclosing bone material is provided. The bone implant comprises a covering, which can be a biodegradable mesh. The covering is configured to be rolled into a diameter to at least partially enclose the bone material within the covering. In some embodiments, the covering includes a body portion and a closure portion adjacent to the body portion. The closure portion is configured to hold the covering in a rolled configuration to a predetermined diameter to at least partially enclose the bone material. A kit and a method of using the bone implant are also provided.

Methods and apparatus are provided for forming a patient-specific surgical implant based on mold system. The apparatus comprises a forming tool and a mold that may be generated using imaging and processing techniques and rapid prototyping methods. The mold apparatus includes at least two non-adjacent surface features for securing an implant forming material (such as a titanium mesh) during the forming process, enabling the implant forming material to be stretched beyond its elastic and thus permanently deformed with the correct patient-specific curvature. The implant may include one or more anatomic surface features for guidance and registration when transferring the implant to a patient.