In accordance with one or more embodiments herein, a system 100 for customizing an implant is provided. The system 100 comprises a processor configured to: i) obtain one or more medical image stacks of a joint; ii) obtain a three-dimensional image representation of the joint based on at least one of said medical image stacks; iii) determine damage to the joint by analyzing said medical image stacks; iv) select an implant template from a predefined set of implant templates having predetermined types and sizes; v) generate a 3D model, in which the marked damage is visualized together with the selected implant template in a proposed position; vi) display the 3D model; vii) receive an approval for said selected implant template in said proposed position; and viii) determine the final shape and dimensions of a customized implant based on said selected implant template and said proposed position.

This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.

An implant resection system for preparing an implant site to replace a defect in an articular surface of a first bone includes a first guide configured to be coupled generally to the first bone. The first guide includes a body portion defining a channel configured to receive a pin, wherein the pin is configured to penetrate and form a longitudinally disposed bore within the first bone. The implant resection system further includes a second guide configured to be coupled generally perpendicular to the first bone proximate to the defect by way of the bore. The second guide includes a drill bit configured to form an excision site through a portion of the articular surface in preparation of receipt of an implant.

Artificial cartilage materials for repair and replacement of cartilage (e.g., load-bearing, articular cartilage). The artificial cartilage materials described herein include triple-network hydrogels including a cross-linked fiber network (e.g., a bacterial cellulose nanofiber network) and a double-network hydrogel (e.g., a double-network hydrogel including polfacrylamide-methyl propyl sulfonic acid). The artificial cartilage may be coated onto or formed into an implant (e.g., plug). The artificial cartilage may include a surface macroporosity, e.g., 0.1-300 micrometers diameter. Also described herein are methods of forming and methods of using the triple-network hydrogel artificial cartilage materials.

A method of manufacturing a bioscaffold implant for a specific patient is provided. The method can comprise obtaining an image of a tissue section of the specific patient from imaging scans of the tissue section, wherein the tissue section includes a resected portion. The method can further comprise determining on the image of the tissue section a surface topography of the resected portion, determining an image of a bioscaffold implant that matches the surface topography of the resected portion, and manufacturing a bioscaffold implant with a surface portion that mirrors the surface topography of the resected portion.

Methods, systems, and devices for treating osteochondral defects (OCDs) are disclosed. The disclosed methods and systems include collecting joint surface data using image-free methods, generating a three-dimensional (3D) healthy bone model based on the joint surface data and a database of healthy bone anatomies, defining the OCD boundary on the joint, generating a 3D implant model based on the 3D healthy bone model and the OCD boundary, manufacturing an implant based on the 3D implant model, generating an implantation plan, the resected cavity on the joint. The implant includes a 3D-printed titanium alloy substrate having a first and second porous layer separated by a nonporous layer. A polymer material is over-molded onto the second porous layer and treated to exhibit properties that mimic cartilage, while the first porous layer allows the implant to fuse to patient bone.

A scaffold (12) for tissue engineering comprises an inner portion (14), an outer portion (16), and a base portion (22) connecting the inner portion and the outer portion. The inner portion (14) comprises a channel (18) surrounded by a first set of one or more walls. The outer portion (16) comprises a second set of one or more walls. The portions are arranged such that the second set of one or more walls substantially surrounds the first set of one or more walls with a spacing between the first and second sets of walls defining a cavity (20) between the inner portion (14) and the outer portion (16). The inner portion (14) and the outer portion (16) may have different shapes; and/or the scaffold (12) may further comprise a filler material in the cavity (20) defined between the inner and outer portions.

The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

The present invention relates to a method for using a lyophilization hyaline cartilage powder to produce a composition for regenerating cartilage, and a composition for regenerating cartilage produced by using the method, the method comprising: A) a step for preparing hyaline cartilage; B) a step for freeze-drying and crushing the hyaline cartilage, and producing a lyophilization hyaline cartilage powder; C) a step for producing an adipose tissue extract from autologous adipose tissue; and D) a step for producing a composition which is for regenerating cartilage and including the lyophilization hyaline cartilage powder and the adipose tissue extract.

The present disclosure provides collagen bioink compositions and chemically uncrosslinked and crosslinked collagen structures including collagen microparticles and scaffolds. Also provided are methods of their fabrication and use. Applications for using these collagen structures include treatments of damaged tissue, particularly those caused by osteoarthritis.