An implant shredder includes a base and a cutting member. The base includes a first chamber and a second chamber intercommunicating with the first chamber. The first chamber includes an inlet. The second chamber includes an outlet. The cutting member is received in the second chamber. The cutting member is driven by a driving member to rotate. The cutting member includes a plurality of cutting edges located on a circumference of a same radius. The plurality of cutting edges is rotatably disposed adjacent to a location intercommunicating with the first chamber. An implant forming method includes creating data of an outline of an implant; producing a shaping mold based on the data; and cutting a to-be-processed object with the implant shredder, mixing the cut to-be-proceed object with a biological tissue glue to obtain a raw material, and filling the raw material into the shaping mold to form the implant.

The present invention relates to the diagnosis and treatment of joint-related diseases, in particular osteoarthritis. Based on the analysis of the microarchitecture, such as microchannels, of the subchondral bone, the present invention provides methods for evaluating the health state of a joint as well as determining whether a joint is prone to develop or has already developed a disease correlated to joint and cartilage destruction. The invention further provides for membranes and other implants mimicking healthy subchondral bone structure suitable for promoting regeneration of joint structure and function.

A system for harvesting bone material from a bone may include a rotary cutter defining a rotary cutter longitudinal axis extending between a rotary cutter proximal end and a rotary cutter distal end. The rotary cutter may have a drive shaft configured to receive input torque, and an osteochondral cutter configured to cut the tissue and receive the tissue material in response to rotation of the osteochondral cutter under pressure against the tissue. The system may further include a bone port defining a bone port longitudinal axis extending between a bone port proximal end and a bone port distal end. The bone port may have a bone port cannulation sized to closely fit over the osteochondral cutter. At least one of the bone port proximal end and the bone port distal end may be securable to the tissue. A stratiform tissue graft may be delivered through the bone port.

Biomaterials for tissue regeneration and engineering applications and methods of making and use thereof are described, as well as constructs and kits derived from the biomaterials. The biomaterials can be derived from extracellular matrix and functionalized to make them crosslinkable and amenable to tuning of their material properties.

Cellulose-reinforced hydrogels may include a cellulose nanofiber network and an interstitial hydrogel portion within interstitial regions of the cellulose nanofiber network, the interstitial hydrogel portion comprising polyvinyl alcohol (PVA), wherein the hydrogel component has a crystallinity of 20% or greater.

A medical implant for cartilage and/or bone repair at an articulating surface of a joint is provided. The implant includes a contoured implant body and at least one extending post. The implant body has an articulating surface configured to face the articulating part of the joint and a bone contact surface configured to face the bone structure of a joint, where the articulating and bone contact surfaces face mutually opposite directions and the bone contact surface is provided with the extending post. A cartilage contact surface connects the articulating and the bone contact surfaces and is configured to contact the cartilage surrounding the implant body in a joint. The articulating surface has a layer that is formed of titanium nitride (TiN) as the wear-resistant material. The cartilage contact surface has a coating that is formed of a material having chondrointegration properties.

A system 100 or designing a surgical kit 700 for articulating surface repair in an anatomical joint of a patient is provided, which comprises at least one processor 120 configured to: determine damage to the anatomical joint; select, from a predefined set of implants having varying dimensions, the implant 300 that is the best fit for repairing the determined damage; select, from a predefined set of insert tools, the insert tool 720 corresponding to the selected implant 300; and design a contact surface 540 of a guide tool 500 to have a shape and contour that is designed to correspond to and to fit the contour of a predetermined area. This enables the use of standardized implants 300 that can be manufactured batch-wise, while still using an individualized guide tool 500 to ensure correct positioning of the implant 300. This helps ensuring that the implant will be positioned in the exact location of the determined damage.

A soft tissue and bone repair system and corresponding method are provided which are particularly useful for labral repairs in the human shoulder. The system comprises at least two guide cannulae capable of being introduced into an anatomical structure of a human body at different entry points for repair of a tear in soft tissue. A pulling line can be passed within the anatomical structure between the guide cannulae. A guide device may be attached to the pulling line and inserted into one of the guide cannula. The guide device is capable of delivering a drilling device into the anatomical structure. The pulling line is capable of being pulled to move an end of the guide device from a one location to another within the anatomical structure to position the drilling device on a desired drilling path to access the tear in soft tissue.

Arthroplasty implant systems and methods are provided for restoring the functionality of a joint. The arthroplasty implant systems may include a threaded cup having a cylindrical shaped body and a flange. A thread may be provided on the cylindrical shaped body. The thread is configured to engage a bone, and the flange is configured to engage a cortical rim of the bone.

A method for use of a double-structured tissue implant or a secondary scaffold stand-alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand-alone secondary scaffold implant or unit for treatment of tissue defects.