Disclosed is directed to a method for restoring bone in an animal comprising: accessing a site to be restored; loading a syringe body with a flowable bone graft material; mating the syringe body with a delivery tube; positioning the delivery tube at the site to be restored; using a syringe piston to advance the said material into the delivery tube; using the syringe piston or a plunger that mates with the delivery tube after removal of the syringe body to deliver the bone graft to the site at a force of less than 50 lbs. extrusion force; wherein said material is at least 75% porous with a mineral to polymer ratio of 80:20.

Nanostructured surfaces on selected substrates are described which are highly resistant to cell adhesion. Such surfaces on medical implants inhibit fibroblast adhesion particularly on nanorough titanium deposited on smooth silicone surfaces. The nanostructured deposited metal coatings can also be engineered so that several cell types, including endothelial, osteoblast, and fibroblast cells, show little if any tendency to attach to the coated surface in vivo.

Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

To provide a sliding member having improved wear resistance, and a method of manufacturing the sliding member. A femoral head ball according to an aspect of the present disclosure includes a composite ceramic containing alumina and at least one oxide other than alumina. A surface roughness Ra of the sliding surface when the femoral head ball slides against a constituent member constituting an artificial joint is not more than 0.01 μm. The sliding surface includes a plurality of recessed portions each having an opening diameter of not more than 2 μm.

An apparatus for use in a chemical vapor infiltration process is disclosed. The apparatus can optionally include any one or combination of a first reaction chamber, a mixing chamber and a second reaction chamber. The mixing chamber can have at least a first inlet, a second inlet and an outlet. The first inlet can be in fluid communication with the first reaction chamber and receive a second precursor gas. The second inlet can be in fluid communication to receive a third precursor gas. The second precursor gas and the third precursor gas can mix within the mixing chamber before passing to the outlet and into the second reaction chamber. The second reaction chamber can contain a substrate that can receive a film deposition from reaction of the second precursor gas and the third precursor gas within the second reaction chamber.

An orthopaedic implant includes: a base including a molding material; a first porous ingrowth material region coupled to the base; a second porous ingrowth material region coupled to the base; and at least one barrier insert coupled to the base, the barrier insert including a barrier material that is configured to prevent introduction of the molding material of the base into some pores of the first porous ingrowth material region and some pores of the second porous ingrowth material region during molding of the base.

The disclosure describes examples of machine-learned model based techniques. A computing system may obtain patient characteristics of a patient and implant characteristics of an implant. The computing system may determine information indicative of an operational duration of the implant based on the patient characteristics and the implant characteristics and output the information indicative of the operational duration of the implant. In some examples, one or more processors may be configured to receive, with a machine-learned model of the computing system, implant characteristics of an implant to be manufactured, apply model parameters of the machine-learned model to the implant characteristics, determine information indicative of dimensions of the implant to be manufactured based on the applying of the model parameters of the machine-learned model, and output the information indicative of the dimensions of the implant to be manufactured.

The present invention discloses a connected structure of a porous surface structure and a substrate, a method for preparing the same, and a prosthesis of the same. The connected structure consists of a pre-connected or integrally formed composite body of a porous surface structure and an intermediate; and a substrate, which is connected to said intermediate to achieve the connection of said composite body to the said substrate; the composite body comprising a first composite region corresponding to a first stiffness; a remaining composite region in the composite body other than the first composite region, which at least contains a second composite region corresponding to a second stiffness; and the first stiffness is less than the second stiffness. The present invention achieves a fastened connection between the composite and the substrate and largely maintains the mechanical properties of the substrate; and it provides a prosthesis with excellent bone ingrowth properties and that the strength of the substrate is not substantially affected.

A method is disclosed for creating a patient-specific orthopedic implant. The method includes creating a numerical representation of an orthopedic implant design based on patient data describing an anatomical, physiological and pathological condition of a patient and simulating a characteristic of the orthopedic implant design based on the numerical representation. The method further includes selecting a patient-specific orthopedic implant design based on the simulated characteristic of the orthopedic implant design and the patient data and constructing at least one patient-specific orthopedic implant based on the selected patient-specific orthopedic implant design.

A medical implant which comprises a porous lattice is fabricated with additive manufacturing techniques such as direct metal laser sintering. A CAD model of the porous lattice is created by defining a trimming volume and merging some lattice elements with adjacent solid substrate.