Compositions and methods for making biocompatible articles are provided. A method includes preparing a 3D printable mixture and depositing successive layers of the mixture in a predetermined pattern to form a porous biocompatible article. The predetermined pattern has a porosity suitable for a bone or cartilage scaffold. Associated 3D printable compositions and porous articles made from the described methods are also described. The preparing a 3D printable mixture can comprise conjugating an alkyne-terminated polymer to a peptide to form a peptide-containing composite, or providing a mixture that comprises a ceramic material and a binder, and wherein the 3D printable mixture comprises from 50 wt. % to 80 wt. % of the ceramic material.

A method for forming a thermoplastic body having regions with varied material composition and/or porosity. Powder blends comprising a thermoplastic polymer, a sacrificial porogen and an inorganic reinforcement or filler are molded to form complementary parts with closely toleranced mating surfaces. The parts are formed discretely, assembled and compression molded to provide a unitary article that is free from discernible boundaries between the assembled parts. Each part in the assembly has differences in composition and/or porosity, and the assembly has accurate physical features throughout the sections of the formed article, without distortion and nonuniformities caused by variable compaction and densification rates in methods that involve compression molding powder blends in a single step.

A prosthetic appendage for attachment to an outer extremity of an amputated limb that is composed of modular elements fabricated by three-dimensional printing. In one embodiment the prosthetic appendage is a leg. The prosthetic leg includes a foot portion and a plurality of modular and three-dimensionally printed limb elements. One of the plurality of limb elements is pivotally coupled to the foot portion and another of the limb elements is configured at one end to receive the outer extremity of the amputated leg. In another embodiment of the present invention the prosthetic appendage is a hand. The prosthetic hand includes a wrist element with one end configured to receive the outer extremity of an amputated hand, a base portion attached to the wrist element and a plurality of modular and three-dimensionally printed finger elements selectively coupled to adjacent finger elements or the base to form prosthetic fingers.

A biological implant is implantable in a base being a part of a living organism. The implant includes an implant body including at least an outer circumferential surface containing a titanium alloy. The implant body is implantable in the base. Based on a first curve indicating a profile of the surface of the implant body obtained with a measurement length of 25.4 .Math.m and a second curve obtained by removing a long-wavelength component from the first curve at a cutoff value of 5 .Math.m in image processing performed on an image of a cut surface of the implant body perpendicular to the outer circumferential surface of the implant body, an arithmetic mean roughness value as a surface roughness value Ra of the outer circumferential surface calculated using the second curve is greater than or equal to 0.2 .Math.M.

A method for removing a stem portion of an orthopedic implant from a bone comprises exposing an implanted orthopedic implant having a body portion, a stem portion interconnected to the body and a porous metal section forming an interconnection between the body and the stem portion. A cutting tool is mounted on a holder connected to an exposed surface of the orthopedic implant. The porous section is aligned with the cutting tool mounted on the holder. The entire porous section is cut by moving the cutting tool therethrough in a direction transverse to the stem portion axis. The implant body portion is then removed and then the stem portion is removed from the bone. The cutting tool may be a saw or chisel which may be mounted on a guide fixed to the body portion.

The present disclosure provides zirconium powder particles comprising pure zirconium powder particles with an oxide layer ranging from 0.05 to 5 microns in thickness and/or zirconium alloy powder particles with an oxide layer ranging from 0.05 to 5 microns in thickness. In some embodiments, the zirconium powder particles may be spherical particles, the zirconium powder particles may range from 5 microns to 125 microns in diameter, and/or the zirconium powder particles may have a median particle size ranging from 25 to 70 microns in diameter. The present disclosure further provides methods of producing medical implants or medical implant components by a process that comprises selectively applying energy to such zirconium powder particles to build the medical implants or the medical implant components. In some embodiments, the methods comprise repeatedly forming a layer of zirconium powder particles and irradiating the layer of zirconium powder particles with an energy source.

A device including a delivery port and a method of delivering a material via a delivery port is disclosed. The device includes a body extending between a proximal surface and a distal surface. The body is sized and configured to be coupled to an anatomical structure at an implantation site. A first inlet port is formed in a distal surface of the body and is sized and configured to receive a first material. A first outlet port is formed in the proximal surface of the body. The first outlet port is coupled to the first inlet port by a first fluid path defined by the body and the first outlet port is sized and configured to provide the first material to a first predetermined location when the body is coupled to the anatomical structure.

An implant intended to be at least partially implanted into a bone by means of an implant part having an endosseous surface, wherein said endosseous surface comprises at least one zone having a surface topography exhibiting: an arithmetic mean peak curvature parameter (Spc) less than or equal to 1 μm.sup.1, a density of peaks parameter (Spd) greater than or equal to 0.020 μm.sup.−2.

A prosthesis for implantation in a de-nucleated intervertebral disc includes a fiber ring-like layer which encloses a polymeric layer to create an annular space. The annular space is inflatable with an in-situ curable liquid polymer and forms an interior cavity. The annular space may be expanded uniformly or differentially to be tailored to the needs of a particular vertebral segment and to achieve optimal disc space width and angle, thereby stabilizing the segment while preserving normal motion of the vertebral segment. The interior cavity provides a void that allows inward deformation of the implant during weight bearing activities and bending. The prosthesis can be elastically deformed through axial elongation to a reduced profile to load into a delivery cannula using pulling techniques.