This disclosure relates to an intraoperative guidance system for total joint replacement of a joint of a patient by a surgeon. The guidance system comprises: an X-ray imaging device for single-shot application of X-ray radiation to the joint and for etecting X-ray radiation to create a digital image of the joint and an implant component during a total joint replacement surgery; and a computer system configured to: store a digital three-dimensional model of the joint; receive the digital image during the total joint replacement surgery; perform registration between the digital image and the digital three-dimensional model to determine a placement of the implant component in the digital image in relation to the digital three-dimensional model; determine an intraoperative simulated erformance metric and provide an indication to the surgeon of the intraoperative simulated performance metric as an assessment of a current placement of the implant component.

This disclosure relates to an intraoperative guidance system for total joint replacement of a joint of a patient by a surgeon. The guidance system comprises: an X-ray imaging device for single-shot application of X-ray radiation to the joint and for etecting X-ray radiation to create a digital image of the joint and an implant component during a total joint replacement surgery; and a computer system configured to: store a digital three-dimensional model of the joint; receive the digital image during the total joint replacement surgery; perform registration between the digital image and the digital three-dimensional model to determine a placement of the implant component in the digital image in relation to the digital three-dimensional model; determine an intraoperative simulated erformance metric and provide an indication to the surgeon of the intraoperative simulated performance metric as an assessment of a current placement of the implant component.

This disclosure relates to an intraoperative localisation system for total joint replacement of a joint of a patient by a surgeon, the joint being associated with a bone. The localisation system comprises: an X-ray imaging device to create a digital X-ray image of the joint and a localisation object during a total joint replacement surgery; a computer system configured to: store a surgical plan comprising a digital three-dimensional model; receive the digital X-ray image of the joint and the localisation object during the total joint replacement surgery; determine a pose of the localisation object relative to the bone or the joint, based on the digital X-ray image; assess the pose of the localisation object against the surgical plan; and provide an indication of a clinical consequence of the pose in relation to the surgical plan to the surgeon.

This disclosure relates to an intraoperative localisation system for total joint replacement of a joint of a patient by a surgeon, the joint being associated with a bone. The localisation system comprises: an X-ray imaging device to create a digital X-ray image of the joint and a localisation object during a total joint replacement surgery; a computer system configured to: store a surgical plan comprising a digital three-dimensional model; receive the digital X-ray image of the joint and the localisation object during the total joint replacement surgery; determine a pose of the localisation object relative to the bone or the joint, based on the digital X-ray image; assess the pose of the localisation object against the surgical plan; and provide an indication of a clinical consequence of the pose in relation to the surgical plan to the surgeon.

This disclosure relates to an intraoperative guidance system. The guidance system comprises: an X-ray imaging device to create a two-dimensional digital image of a joint and an implant component; and a computer system configured to: store an initial three-dimensional model of the joint and the implant component; receive two or more two-dimensional digital images of the joint and the implant component; create a digital three-dimensional model of the joint and the implant component based on the two or more two-dimensional digital images; perform registration between the digital three-dimensional model and the initial three-dimensional model to determine a placement of the implant component; determine an intraoperative simulated performance metric by simulating movement of the digital three-dimensional model based on the placement; and provide an indication to a surgeon of the intraoperative simulated performance metric as an assessment of a current placement of the implant component.

This disclosure relates to an intraoperative guidance system. The guidance system comprises: an X-ray imaging device to create a two-dimensional digital image of a joint and an implant component; and a computer system configured to: store an initial three-dimensional model of the joint and the implant component; receive two or more two-dimensional digital images of the joint and the implant component; create a digital three-dimensional model of the joint and the implant component based on the two or more two-dimensional digital images; perform registration between the digital three-dimensional model and the initial three-dimensional model to determine a placement of the implant component; determine an intraoperative simulated performance metric by simulating movement of the digital three-dimensional model based on the placement; and provide an indication to a surgeon of the intraoperative simulated performance metric as an assessment of a current placement of the implant component.

The present invention is directed generally to (1) an articulating junction, and articulation method thereof, wherein articulation is facilitated by a plurality of magnetic particles; (2) an articulating junction, and articulation method thereof, wherein the stability and fluidity of the junction is based, at least in part, on the magnetic field(s) of the plurality of magnetic particles; and (3) reducing the resistance to articulation and/or increasing the structural integrity and support, of the articulating junction, via electro-magnetism. Further, the present invention is directed generally to the synergistic combination of magnetic particles and preferred bio-implant-materials and additive-manufacturing methods along with Baker correlation codes. Further, the present invention is directed to an artificial joint for implantation into a living body and methods for constructing such an artificial joint.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

An example method includes obtaining, a virtual model of a portion of an anatomy of a patient obtained from a virtual surgical plan for an orthopedic joint repair surgical procedure to attach a prosthetic to the anatomy; identifying, based on data obtained by one or more sensors, positions of one or more physical markers positioned relative to the anatomy of the patient; and registering, based on the identified positions, the virtual model of the portion of the anatomy with a corresponding observed portion of the anatomy.

Orthopedic systems and methods are provided for use in preparing joints for implants. Specifically, hip preparation systems and methods are disclosed which can include a surgical orientation device. The hip preparation systems and methods can be used, for example, to orient the hip during the procedure, determine the orientation of an anatomical plane or planes, and orient a prosthetic component or components.