A transtibial prosthetic socket frame may include a distal base assembly having a base plate, a carriage configured to support a socket suspension arrangement, and a distal prosthetic component connector. The distal base assembly supports a set of struts that includes two anterior struts and a single posterior strut. The set of struts and distal base assembly collectively define a prosthetic socket cavity having a central longitudinal axis and a residual limb hosting volume. The distal prosthetic component connector has a connecting adapter that is rotatable with respect to the prosthetic socket, and moveable with respect to the base plate between being aligned with the prosthetic socket's central longitudinal axis and a position offset therefrom.

A limb prosthesis including a socket having an inner cavity configured for disposal therein of a limb stump of a user, and a mechanism for changing an inner diameter of the inner cavity by a remote control, where the inner diameter includes a lining disposed within the cavity, having between fifteen and sixty of only longitudinal inflatable cells where each of the cells is situated immediately adjacent to two other of the cells such that no intervening element aside from a shared border is provided between two such immediately adjacent cells, thereby diminishing blood flow blockage in the limb stump, and a pump assembly, for inflating and deflating the inflatable lining to a desired air pressure set by a user or by a controller, the remote control being in data communication with the pump assembly, for instructing the pump assembly to inflate or deflate the lining to the desired air pressure.

A method of manufacturing a microfluidic architecture having at least one channel disposed therein. Steps can include pouring an uncured polymeric material into a mould to produce a first layer; at least partially curing the first layer; and forming the at least one channel by disposing a support material on the first layer; pouring an uncured polymeric material onto the first layer to form a second layer to thereby encapsulate the support material; and at least partially curing the second layer such that the first layer and second layer together form the microfluidic architecture; wherein the support material undergoes a phase change during the process of forming the at least one channel. The phase change of the support material enables the material to be more easily disposed and/or removed after formation of the channel.