The disclosure provides a system for EGRT. The system may include a radiotherapy device for treating a subject. The radiotherapy device may include a scintillation camera that is directed at an ROI of the subject. The subject may be injected with a radioactive tracer or implanted with a radioactive marker before treatment. The ROI may undergo a physiological motion during the treatment. The system may deliver a treatment session to the subject by the radiotherapy device. During the treatment session, the system may acquire a target image of the ROI indicative of a distribution of the radioactive tracer or the radioactive maker in the ROI by the scintillation camera, and adapt a radiation beam to be delivered to the subject with respect to the physiological motion of the ROI by adjusting the radiation beam based on the target image.

The invention relates to a detection system for automatic detection of bone cancer metastases from a set of isotope bone scan images of a patients skeleton, the system comprising a shape identifier unit, a hotspot detection unit, a hotspot feature extraction unit, a first artificial neural network unit, a patient feature extraction unit, and a second artificial neural network unit.

[Problem to be Solved] To improve stability of automatic normalization of a bone scintigraphy image. [Solution] A preferred embodiment includes: creating a pixel value histogram of image data representing a bone scintigraphy image; setting a plurality of thresholds related to pixel values based on the pixel value histogram; calculating respective average pixel values for the set thresholds; arranging the calculated average pixel values in order from the largest value; and determining a reference value for normalizing the image data based on at least part of a set of the average pixel values arranged in the order. The determining the reference value includes: determining one straight line that approximates a region of small average pixel values out of the set of the average pixel values arranged in the order; and calculating the reference value based on the straight line.

A method includes obtaining a first image of a patient procured during an X-ray, analyzing the first image for one or more unmasked anomalies, shifting the first image to provide a shifted image, obtaining a residual image comprising a combination of the first image and the shifted image, and analyzing the residual image for one or more masked anomalies, where the one or more masked anomalies include anomalies that went undetected in the analysis of the first image for the one or more unmasked anomalies due to a presence of one or more masking features in the first image.

A radiographing control apparatus includes a hardware processor. A radiographic imaging apparatus is exposed to a radiation from an irradiating apparatus through the subject. The hardware processor retrieves pre-exposure image data which the radiographic imaging apparatus generates by performing a pre-exposure to the subject at a pre-exposure dose of less than a dose of a subsequent main exposure, and calculates a total dose required to obtain diagnostic image data to be used for diagnosis. The hardware processor outputs a main exposure dose based on the calculated total dose to the irradiating apparatus and the radiographic imaging apparatus. The hardware processor retrieves main exposure image data which the radiographic imaging apparatus generates by performing the main exposure to the subject at the main exposure dose, and combines the main exposure image data with the pre-exposure image data to generate the diagnostic image data.

A method is disclosed for graphically depicting a marker which is applied to an examination object in an imaging system. In an embodiment, the position of the marker is ascertained by way of a first measuring method. An image of the examination object is provided on the basis of a second measuring method, in which image the position of a graphical object that represents the marker in the image is ascertained and depicted on the basis of the first measuring method.

An x-ray imaging apparatus includes a holdable housing; an x-ray source mounted within the housing and configured to output a fan beam of x-rays; and a hoop chopper wheel rotatably mounted within the housing and comprising an x-ray attenuating material configured to block x-rays of the fan beam. The hoop chopper wheel defines a set of beam apertures of which each aperture is configured to pass therethrough a corresponding angular portion of x-rays from the fan beam, so that rotation of the hoop chopper wheel causes scanning of the corresponding angular portion of x-rays. The x-ray source may be a transmission-type x-ray tube configured to output the fan beam centered in an x-ray extraction direction forming an angle greater than 0 degrees with respect to a longitudinal axis of the x-ray tube.

The present invention relates to a method of in vivo imaging with meta-[.sup.123I]iodobenzylguanidine ([.sup.123I]mIBG) and more particularly wherein said method is used to stratify a defined subset of subjects with heart failure into particular treatment regimens.

[Problem to be Solved] To improve stability of automatic normalization of a bone scintigraphy image.

[Solution] A preferred embodiment includes: creating a pixel value histogram of image data representing a bone scintigraphy image; setting a plurality of thresholds related to pixel values based on the pixel value histogram; calculating respective average pixel values for the set thresholds; arranging the calculated average pixel values in order from the largest value; and determining a reference value for normalizing the image data based on at least part of a set of the average pixel values arranged in the order. The determining the reference value includes: determining one straight line that approximates a region of small average pixel values out of the set of the average pixel values arranged in the order; and calculating the reference value based on the straight line.

A radio therapy apparatus (100) includes a tissue of interest tracker (124) that receives a first image of tissue of interest and a second later acquired spectral image of the tissue of interest and tracks a change in a geometry and/or location of the tissue of interest based at least on the first and second images and generates a signal indicative of the change. The second image is generated based on a first spectral signal corresponding to an output of an energy-resolving radiation sensitive detector array for a first predetermined energy range and a second spectral signal corresponding to an output of the energy-resolving radiation sensitive detector array for a second predetermined energy range and visually enhances scanned structure corresponding to the first or second signals while visually suppressing scanned structure corresponding to the other of the first or second signals. An adaptive planner (126) updates a radiotherapy treatment plan based on the signal.