Methods and systems are described for assessing a vessel obstruction. The methods and systems obtain a volumetric image dataset of a myocardium and at least one coronary vessel, wherein the myocardium comprises muscular tissue of the heart. A three-dimensional (3D) image corresponding to a coronary vessel of interest is created from the volumetric image dataset. Feature data that represents features of both the myocardium and the coronary vessel of interest is generated. At least some of the feature data is determined by a first machine learning-based model based on the 3D image. A second machine learning-based model is used to determine at least one parameter based on the feature data, wherein the at least one parameter represents functionally significant coronary lesion severity of the coronary vessel of interest.

A method is for providing decision-supporting data. In an embodiment, the method includes receiving photon-counting computed tomography data relating to an examination region; determining a location of a thrombus in the examination region, based on the photon-counting computed tomography data received; generating the decision-supporting data, relating to at least one of the thrombus and a vascular wall in a region of the thrombus, based on the photon-counting computed tomography data received and the location of the thrombus determined; and providing the decision-supporting data generated.

Systems and methods are disclosed for simulating microvascular networks from a vascular tree model to simulate tissue perfusion under various physiological conditions to guide diagnosis or treatment for cardiovascular disease. One method includes: receiving a patient-specific vascular model of a patient's anatomy, including a vascular network; receiving a patient-specific target tissue model in which a blood supply may be estimated; receiving joint prior information associated with the vascular model and the target tissue model; receiving data related to one or more perfusion characteristics of the target tissue; determining one or more associations between the vascular network of the patient-specific vascular model and one or more perfusion characteristics of the target tissue using the joint prior information; and outputting a vascular tree model that extends to perfusion regions in the target tissue, using the determined associations between the vascular network and the perfusion characteristics.

Embodiments relate to extracting blood vessel geometry from one or more optical coherent tomography (OCT) images for use in analyzing biological structures for diagnostic and therapeutic applications for diseases that can be detected by vascular changes in the retina. An OCT image refers generally to one or more images of any dimension obtained using any one or combination of OCT techniques. Some embodiments include a method of identifying a region of interest of a retina from a plurality of retinal blood vessels in at least one optical coherence tomography (OCT) image of at least a portion of the retina. Some embodiments include a method of distinguishing between a plurality of retinal layers from vessel morphology information of retinal blood vessels in at least one optical coherence tomography (OCT) image of at least a portion of the retina.

An automatic clipping technique capable of satisfactorily extracting blood vessels to be extracted is provided. A specific tissue extraction mask image which is created by extracting a specific tissue (for example, a brain) from a three-dimensional image acquired by magnetic resonance angiography and a blood vessel extraction mask image which is created by extracting a blood vessel from an area (a blood vessel search area) which is determined using a preset landmark position and the specific tissue extraction mask image are integrated to create an integrated mask. By applying the integrated mask to the three-dimensional image, a blood vessel is clipped from the three-dimensional image.

The present disclosure provides systems and methods for diagnosing disease. In some aspects, an imaging system is provided that includes a light source configured to illuminate a retina of the eye with light, one or more imaging devices configured to receive light returned from the retina to generate one or more spatial-spectral images of the retina, and a computing device configured to receive the one or more spatial-spectral images of the retina, evaluate the one or more spatial-spectral images, and identify one or more biomarkers indicative of a neurogenerative pathology.

A non-transitory computer-readable medium (CRM) storing computer program code executed by a computer processor that executes a process, an information processing apparatus, and a model generation method that outputs complication information for a medical treatment. The process includes acquiring a medical image obtained by imaging a lumen organ of a patient before treatment, inputting the acquired medical image into a trained model so as to output complication information on a complication that is likely to occur after the treatment when the medical image is received, and outputting the complication information. Preferably, complication information including a type of the complication that is likely to occur and a probability value indicating an occurrence probability of the complication of the type is output.

A non-transitory computer-readable medium (CRM) storing computer program code executed by a computer processor that executes a process, an information processing apparatus, and model generation method that generates an image of a lumen organ. The process includes acquiring a first image obtained by imaging a lumen organ of a patient based on an ultrasound signal of a first frequency; and generating a second image by inputting the acquired first image into a model, the model being learned to generate, when the first image is input, the second image in which the lumen organ is imaged based on an ultrasound signal of a second frequency. Preferably, the second image, in which a part of an image region of the first image is converted into the second frequency, is generated using the model, and a synthesis image is generated in which the second image is superimposed to the first image.

A computer is caused to perform processing of: acquiring a plurality of medical images generated based on signals detected by a catheter inserted into a lumen organ while the catheter is moving a sensor along a longitudinal direction of the lumen organ, the lumen organ including a main trunk, a side branch branched from the main trunk, and a bifurcated portion of the main trunk and the side branch; and recognizing a main trunk cross-section, a side branch cross-section, and a bifurcated portion cross-section by inputting the acquired medical images into a learning model configured to recognize the main trunk cross-section, the side branch cross-section, and the bifurcated portion cross-section.

A non-transitory computer-readable medium (CRM) storing computer program code executed by a computer processor that executes a process of acquiring a medical image generated based on a signal detected by a catheter inserted to a lumen organ, estimating a position of an object at least included in the acquired medical image by inputting the medical image to a first learning model for estimating a position of an object included in the medical image, extracting from the medical image an image portion by using the estimated position of the object as a reference, and recognizing the object included in the extracted image portion by inputting the image portion to a second learning model for recognizing an object included in the image portion.