A system for implantation of a stent in a body lumen may include an elongate tubular member having a lumen extending therein, a stent configured to shift from a delivery configuration to a deployed configuration, and an adhesive structure configured to secure the stent to the body lumen in the deployed configuration. The stent may be disposed within the lumen of the elongate tubular member in the delivery configuration. The adhesive structure may be disposed within the lumen of the elongate tubular member adjacent the stent in a substantially inert state. The adhesive structure may be configured to adhere to the stent and the body lumen after the stent and the adhesive structure are deployed into the body lumen from the lumen of the elongate tubular member.

Vascular remodeling devices can include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchor the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection.

Vascular remodeling devices can include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchor the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection.

Systems for treating an aneurysm in a cerebral vessel and methods of use are described. In one embodiment, the system includes an elongate tubular member having a lumen, an expandable stent, and a delivery device. The expandable stent has a constrained state that is configured for delivery through the lumen of the elongate tubular member, and an expanded state configured for placement within the cerebral vessel adjacent the aneurysm. The delivery device includes an elongate member and a self-expandable portion. The proximal end of the self-expandable portion is coupled to the elongate member at or near the distal end of the elongate member. The self-expandable portion of the delivery device includes a tubular mesh structure having a constrained state and an expanded state. The stent is engaged (e.g., mechanical, frictional, or intermeshing) with the self-expandable portion of the delivery device.

Systems for treating an aneurysm in a cerebral vessel and methods of use are described. In one embodiment, the system includes an elongate tubular member having a lumen, an expandable stent, and a delivery device. The expandable stent has a constrained state that is configured for delivery through the lumen of the elongate tubular member, and an expanded state configured for placement within the cerebral vessel adjacent the aneurysm. The delivery device includes an elongate member and a self-expandable portion. The proximal end of the self-expandable portion is coupled to the elongate member at or near the distal end of the elongate member. The self-expandable portion of the delivery device includes a tubular mesh structure having a constrained state and an expanded state. The stent is engaged (e.g., mechanical, frictional, or intermeshing) with the self-expandable portion of the delivery device.

A stent device including a stent coated with a photosensitizer, the stent including a pair of electrodes; and a circuit fixed to the stent, the circuit including a light emitting diode, a power receiving means for wirelessly receiving power from the outside, and converting the power to electric power; a second communicating means for receiving a control command from the outside; and a second control means for applying, based on the control command, the electric power to the electrodes causing an electric current to flow through the stent between the electrodes, the flow causing heating of the stent, and for controlling a temperature of the stent to provide hyperthermia therapy to a tumor, the second control means further for applying, based on the control command, the electric power to the light emitting diode to emit a predetermined wavelength of light to the photosensitizer to provide photodynamic therapy to the tumor.

A vascular prosthesis (e.g., stent), and packaging and delivery system to selectively deliver a vascular prosthesis are described. In some embodiments, the vascular prosthesis utilizes a low porosity and high porosity section, and the packaging and delivery system allows the prosthesis to be delivered such that the position of the low porosity and high porosity sections of the prosthesis can vary.

An implantable endoluminal prosthesis for use in the treatment of aneurysm involving branches is described, where at least one self-expandable braided framework extending along an axis is able to expand from a radially compressed state in a delivery configuration to a radially expanded state. The self-expandable braided framework includes a plurality of layers of wires made of biocompatible material forming a lattice with a plurality of wires of said layers; the wires being integrated in the mesh of at least one of the adjacent layers; the self-expandable braided framework including a lumen in a cylindrical form; characterized in that, in radially expanded state, a ratio of a thickness of a wall of the implantable endoluminal prosthesis in the radially expanded state to the diameter of wire being greater than 3.0; and the surface coverage ratio (SCR) of the braided framework is at least 30% and at most 50%.

An implantable endoluminal prosthesis for use in the treatment of aneurysm involving branches is described, where at least one self-expandable braided framework extending along an axis is able to expand from a radially compressed state in a delivery configuration to a radially expanded state. The self-expandable braided framework includes a plurality of layers of wires made of biocompatible material forming a lattice with a plurality of wires of said layers; the wires being integrated in the mesh of at least one of the adjacent layers; the self-expandable braided framework including a lumen in a cylindrical form; characterized in that, in radially expanded state, a ratio of a thickness of a wall of the implantable endoluminal prosthesis in the radially expanded state to the diameter of wire being greater than 3.0; and the surface coverage ratio (SCR) of the braided framework is at least 30% and at most 50%.

A stent for insertion into an intracranial blood vessel of the cerebral venous sinus system includes a proximal end, a distal end, a body between the proximal end and the distal end, the body comprising a plurality of wires in a closed pattern, wherein the stent is configured for insertion into an intracranial blood vessel of the cerebral venous sinus system. The stent is further capable of being repositioned, retrieved/re-sheathed, and removed for more precise delivery.