Devices and methods can be used for the endoscopic treatment of conditions such as obesity and metabolic diseases. For example, this document provides devices and methods for bypassing portions of the GI tract that can reduce nutritional uptake, decrease weight, and improve diabetes control. The devices are advantageously designed for migration resistance, reflux prevention, and ease of implantation.

A gastric tube for use in a bariatric surgical procedure includes an elongate tube and a movable component supported on an outer surface of the elongate tube. The elongate tube has a non-circular cross section along at least a portion of a length of the elongate tube. The movable component is movable between an unexpanded configuration and an expanded configuration. In the unexpanded configuration, the movable component is disposed in abutting engagement with the outer surface of the elongate tube. In the expanded configuration, the movable component bows outwardly from the outer surface of the elongate tube.

An volume filling device for treatment of obesity is placed outside the stomach wall of the patient to reduce the inner volume of the stomach, thereby affecting the patient's appetite. By providing the volume filling device outside the stomach wall, contact with stomach acids is avoided, thereby increasing the life of the device.

A stent for repairing post-anastomasis (e.g., bariatric) surgery leaks is formed by an elongated tube having a proximal flare-shaped flange, an enlarged middle section, and a distal flare-shaped flange, where an exterior surface of the elongated tube is substantially covered with a polymer.

A method for shortening a duodenum of a subject, the method including: manipulating a first surface of the duodenum wall such that a first portion of the first surface of the duodenum wall is layered onto a second portion of the first surface of the duodenum wall, thereby creating at least one fold in the first surface of the duodenum wall, and securing, utilizing at least one implant, the position of the at least one fold in relation to a surrounding surface of the duodenum wall, thereby shortening the duodenum of the subject.

An expandable intragastric device, configured for being positioned into the stomach by an endoscopic procedure is provided. The device is capable of assuming a minimum-encumbrance configuration for delivery into the stomach and an expanded configuration for use in situ. The device also includes a balloon structure, which is capable of assuming a deflated configuration for delivery into the stomach and an inflated configuration for occupying a part of the stomach inner space. The overall configuration of the device is such that, once it is delivered in the stomach, food passes into the inner lumen of the supporting tubular body and into the intestine.

The present invention provides combination therapies for treating a metabolic disorder, such as type 2 diabetes, obesity, and related comorbidities (e.g., NASH or NAFLD)) in an individual undergoing treatment with a gastrointestinal implant. The combination therapies described herein include methods for treating an individual with a gastrointestinal implant with a metabolic agent, a bariatric procedure, and/or a microbiota modulator.

An intragastric device including (1) a first wire mesh structure having a pre-deployment shape, a post-deployment shape greater than the pre-deployment state, and one or more openings on an upper portion of the first wire mesh structure that are configured to permit food to enter the device, (2) a second wire mesh structure having a pre-deployment shape a post-deployment shape greater than the pre-deployment state, and one or more openings on a lower portion of the second wire mesh structure that are configured to permit food to exit the device. A sleeve may be coupled to the lower portion of the wire mesh structure. An anti-migration collar may interconnect the wire mesh structure and the sleeve. In use, food enters the upper portion of the first wire mesh structure, passes through both wire mesh structures, and then exits the lower portion of the second wire mesh structure.

A stent for repairing post-anastomasis (e.g., bariatric) surgery leaks is formed by an elongated tube having a proximal flare-shaped flange, an enlarged middle section, and a distal flare-shaped flange, where an exterior surface of the elongated tube is substantially covered with a polymer.

A surgical anchor device for being anchored on the mucous membrane of the inner wall of the intestine, the device having a temporary anchor element presenting anchoring that can be modified in a controlled manner and having a first substantially cylindrical multiply-perforated wall presenting properties of radial elasticity whereby the first wall presents an outer diameter that can be varied in controlled manner, wherein a portion of the inner surface of the first wall is lined with an independent leakproof inner sheath having only its longitudinal ends fastened to the anchor element to define a suction chamber between the inner sheath and the first wall, the temporary anchor element being coupled to a flexible or semi-rigid tube extending outside the anchor element, an open end of the injection-suction tube opening out into the suction chamber enabling air to be injected into or sucked out from the suction chamber.