A device comprising a heat-generating component that comprises an alkali metal is provided. The alkali metal in the presence of water at a point of contact of the device undergoes an exothermic reaction to generate heat in situ. The amount of heat generated is proportional to and/or limited by the amount (or moles) of water at the point of contact, and the heat generated is sufficient to achieve an increase in temperature at the point of contact to achieve a therapeutic or beneficial result. In one embodiment, the device is used for reducing sweat production in a subject suffering from excessive sweating or hyperhidrosis. In other embodiments, the device is used to substantially sterilize a surface or render a surface substantially aseptic.

Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

Methods of operating a haptic actuator to apply physical and/or thermal sensations to a user to provide subjective symptom relief to a user are described. In some embodiments, a haptic actuator may be automatically activated when one or more detected user states are compared to one or more predetermined activation parameters to determine the user is experiencing an episode related to a condition of the user. In another embodiment, one or more operating parameters of a haptic actuator may be updated if the haptic actuator did not provided a desired amount of subjective symptom relief to a user during use. In yet another embodiment, a haptic actuator may create an event log based on activation events when the haptic actuator is used to provide symptom relief for a condition of the user.

A heating/cooling therapy treatment pad system incorporates a plurality of therapy pads that can be coupled together by connectors and attachments to form an integrated therapy pad assembly. The thermal pads have pouches for receiving thermal inserts that may be heated or chilled. The thermal inserts may be cylindrical in shape and there may be thermal insert gaps, or spaces between the pouches to enable better conformability of the therapy pad to a person's body, such as around the neck. The heating/cooling therapy treatment pad system may include a neck therapy pad, spine therapy pad, head and face therapy pads, shoulder therapy pad, lumbar therapy pad, armpit thermal therapy pad and a thermal therapy pad vest. The system of pads interconnect to provide tailored thermal therapy to multiple areas of a user's body and may be used to effectuate rapid cooling and in particular for those suffering from heat exhaustion.

Treatment systems, methods, and apparatuses for treating acne, hyperhidrosis, and other skin conditions are described. Aspects of the technology can include cooling a surface of a patient's skin and detecting changes in the tissue. The tissue can be cooled a sufficient length of time and to a temperature low enough to affect glands or other targeted structures in the skin.

A heating/cooling therapy treatment pad system incorporates a plurality of therapy pads that can be coupled together by connectors and attachments to form an integrated therapy pad assembly. The thermal pads have pouches for receiving thermal inserts that may be heated or chilled. The thermal inserts may be cylindrical in shape and there may be thermal insert gaps, or spaces between the pouches to enable better conformability of the therapy pad to a person's body, such as around the neck. The heating/cooling therapy treatment pad system may include a neck therapy pad, spine therapy pad, head and face therapy pads, shoulder therapy pad, lumbar therapy pad, armpit thermal therapy pad and a thermal therapy pad vest. The system of pads interconnect to provide tailored thermal therapy to multiple areas of a user's body and may be used to effectuate rapid cooling and in particular for those suffering from heat exhaustion.

A wearable therapy system comprises a therapy pack, a therapy pack holder including a body and a first fastener system, the body being configured to removably receive the therapy pack, and a therapy garment configured to be worn by a user and comprising at least one attachment area including a second fastener system. The therapy pack holder is removably attachable to the attachment area in a plurality of positions with the first fastener system engaging the second fastener system to secure the therapy pack in relation to the therapy garment.

Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described as well as for providing for other treatments. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance of cellulite. Treatments can include cooling a surface of a patient's skin and detecting at least one freeze event in the cooled skin. The treatment system can continue cooling the patient's skin after the freeze event(s) are detected so to maintain at least a partially frozen state of the tissue for a period of time.

A compress for treating and preventing radiation dermatitis, comprising a reservoir layer configured to store and release a mixture of skin-cooling ingredients, wherein the compress is cold before applying to skin exposed to radiation therapy or becomes cold after applying to skin exposed to radiation therapy.

A device comprising a heat-generating component that comprises an alkali metal is provided. The alkali metal in the presence of water at a point of contact of the device undergoes an exothermic reaction to generate heat in situ. The amount of heat generated is proportional to and/or limited by the amount (or moles) of water at the point of contact, and the heat generated is sufficient to achieve an increase in temperature at the point of contact to achieve a therapeutic or beneficial result. In one embodiment, the device is used for reducing sweat production in a subject suffering from excessive sweating or hyperhidrosis. In other embodiments, the device is used to substantially sterilize a surface or render a surface substantially aseptic.