A method of preparing cryogenic air for use in cryotherapy procedures, characterized in that liquid nitrogen (1) is fed from a cryogenic nitrogen tank (2) via a cryogenic duct (3) to at least one exchanger (4), wherein at the same time a breathing mixture (6), containing oxygen in a concentration of 17% to 100%, is fed, via an oxygen duct (7), from a breathing mixture (6) source (5), through the filter (8), to at least one exchanger (4), then in at least one exchanger (4), by means of a heat exchange between the breathing mixture (6) and liquid nitrogen (1), the breathing mixture (6) is cooled to the set temperature of minus 80° C. to minus 160° C., and then the cooled breathing mixture (6) is fed from at least one exchanger (4), via an upper pipe (9).

An endorectal cooling device (ECD) includes an elongated body, a cooling fluid circuit, and a gas bubble removal device. The elongated body includes an insertable portion for insertion into a patient's rectum and an external portion that remains external to the rectum. The cooling fluid circuit is defined in the elongated body from the external portion to the insertable portion and circulates cooling fluid to regulate a temperature of a cooling surface on the insertable portion. The gas bubble removal device can include a coil, a tube, a mesh, and/or a hole that is disposed on or defined in the insertable portion of the elongated body, such as the cooling surface. A low-pressure source, such as a vacuum pump or a Venturi structure, can be fluidly coupled to the gas bubble removal device to remove fluid and bubbles by a suction force after the ECD is inserted into the rectum.

A method of preparing cryogenic air for use in cryotherapy procedures, using liquid nitrogen and gaseous oxygen, characterized in that liquid nitrogen (1) is fed from a cryogenic nitrogen tank (2) via a cryogenic duct (3) to a reactor (4), wherein simultaneously a gas (7) containing oxygen in a concentration from 20% to 100% is fed from an oxygen source (5) to the reactor (4), through a gas duct (6), then, in the reactor (4), the liquid nitrogen (1) is evaporated using the gas (7) and both these components are mixed together, forming a cold breathable mixture (8), cooled to a set temperature of minus 80° C. to minus 160° C., which is further fed through a cold duct (9) terminated with an outlet (10) to a cryochamber (11).

This application relates to a hand-held cooling device for supplying a cryogen to a target region for cryotherapy. The device can include a cryogen container configured to contain a first cryogen having a first temperature and a nozzle configured to spray a first modified cryogen to the target region, the first modified cryogen having a second temperature higher than the first temperature. The device can also include a cryogen temperature regulator configured to receive the first cryogen and output the first modified cryogen to the nozzle, the cryogen temperature regulator disposed closer to the nozzle than the cryogen container. The cryogen temperature regulator can include a holder tube, a porous structure disposed inside a holder tube and a heater disposed around the holder tube and heating the holder tube so as to increase the first temperature to the second temperature while the first cryogen passes through the porous structure.

A system to provide physical therapy in the form of heating, cooling and/or percussion, comprising: a device that contains a battery, a motor, and a switch to turn the device on or off or put the device in heating mode or put the device in cooling mode or put the device in percussion mode; wherein the device contains a motor and a pushing rod that supply the movement that results in percussion of a removable heating/cooling attachment and a removable percussion attachment; wherein the front of the device connects to the removable heating/cooling attachment that contains an electronic component to control heating or cooling and a cooling fan; wherein the removable heating/cooling attachment can be used for heating or cooling; wherein a housing shell for the heating/cooling attachment is made of plastic, foam, or metal, or any combination of plastic, foam and metal; wherein the front part of the heating/cooling attachment is made of metal that has the capability to be in contact with human skin in order to provide either heating or cooling at fixed or adjusted degrees that are optimal for physical therapy and/or blood circulation; wherein the removable heating/cooling attachment can be replaced by the removable percussion attachment that is used for percussion; wherein the removable percussion attachment can be placed on the skin of a user in order to provide percussion at fixed or adjusted speeds that are optimal for physical therapy.

Liquid ventilator and methods integrating the concept of total liquid ventilation (TLV) using liquid volumes below functional residual capacity (FRC) of mammal's lungs are disclosed. Beyond the automatization of the whole process, the technology has been up-scaled to confirm that TLV at residual volumes below FRC can provide a safe procedure while enabling the full potential of TLV in a mammal such as humans or adult-sized animals. Such tidal liquid ventilation strongly differs from the previously known TLV approach, opening promising perspectives for a safer clinical translation. Also disclosed are apparatus and method for safe and fast induction of hypothermia during liquid ventilation of a mammal.

A directable, portable appliance in combination with an adjustable set-point digital temperature controller for non-contact remotely monitoring infrared temperatures of a selected area of human skin and activating an electrical fan for directing cooling air over the selected skin areas of individuals experiencing episodes of thermal chaos, i.e., hot flashes.

In an exemplary embodiment of the present disclosure, a sleeping environment control device using reinforcement learning is disclosed. The sleeping environment control device using reinforcement learning includes: a main body on which a user is located; a sensor unit configured to measure a biometric signal of the user and generate current state information and post-operation state information; an operation unit configured to control a temperature and humidity of the main body in order to change a sleeping state of the user based on a control signal of a processor; a processor including one or more cores; and a memory configured to store program codes executable in the processor, in which the processor may include: a sleeping adequacy information generation module which generates current sleeping adequacy information of the user based on the current state information and generates post-operation sleeping adequacy information of the user based on the post-operation state information; an operation information determination module which determines operation information controlling an operation of the operation unit by using an operation determination algorithm based on the current sleeping adequacy information; and an operation adequacy determination module which updates the operation determination algorithm by comparing the post-operation sleeping adequacy information with reference sleeping adequacy information and determining adequacy for the operation.

A cryotherapy apparatus including a heat exchanger, a cryotherapy chamber, cryogenic nitrogen supply and exhaust conduits to and from the heat exchanger, an air return conduit to flow warmed air from the cryotherapy chamber to the heat exchanger, an air supply conduit to flow chilled air from the heat exchanger to the cryotherapy chamber, a variable speed fan to cause flow of air through a loop including the air supply and return conduits, the heat exchanger, and the cryotherapy chamber, and a controller programmed to control the flow rate of air by regulating the speed of the variable speed fan according to a treatment protocol; and a method of delivering cryotherapy according to a customized treatment protocol taking into account one or more of: a patient's treatment goals, a customization factor, a personalization factor, and an adaptation factor.

This application relates to a hand-held cooling device for supplying a cryogen to a target region for cryotherapy. The device can include a cryogen container configured to contain a first cryogen having a first temperature and a nozzle configured to spray a first modified cryogen to the target region, the first modified cryogen having a second temperature higher than the first temperature. The device can also include a cryogen temperature regulator configured to receive the first cryogen and output the first modified cryogen to the nozzle, the cryogen temperature regulator disposed closer to the nozzle than the cryogen container. The cryogen temperature regulator can include a holder tube, a porous structure disposed inside a holder tube and a heater disposed around the holder tube and heating the holder tube so as to increase the first temperature to the second temperature while the first cryogen passes through the porous structure.