An object of the present invention is to provide a heat-generating device with which a warm sensation is persistently perceived, and which can effectively exert a heating effect. In a heat-generating device that is used by being attached to skin, (1) a packaging material constituting a skin attachment surface of a housing is formed of a laminated sheet in which at least a moisture absorption layer that absorbs moisture and a moisture barrier layer that blocks penetration of moisture are laminated in this order from the adhesive layer, (2) an adhesive layer is partially provided on a surface of the moisture absorption layer, and (3) a warming agent that allows an enhanced warm sensation to be perceived in the presence of moisture is contained in at least one of the adhesive layer and the moisture absorption layer. This heat-generating device thereby has improved persistence of a perceived warm sensation, and can exert a markedly high heating effect.

A means for controlling the temperature of a warming material includes an air-permeable film or the like. The warming material includes the temperature control means and a heating composition. The temperature control means for controlling the heating temperature of the warming material includes one or more aliphatic compounds that have a melting point of 35-65° C. and a solubility in water (g/100 mL) at 20° C. of 5 or less.

Disclosed is a self-heating thermal-insulation multilayer film comprising a structure of at least three layers, which from outside to inside are respectively: an outer layer (1) formed of an air permeable material; a heat-generating layer (2) loaded with heat-generating composition (21) that generates heat on contact with air, at least an upper sealing surface of the heat-generating layer that is in contact with the outer layer being formed of an air permeable material; and an thermal-insulation layer (3) formed of a material having waterproof and thermal-insulation properties. The present self-heating thermal-insulation film is structurally simple, is not constrained by environmental resources, does not require energy supply from an external energy source, is safe and stable, uniformly generates heat, and can effectively prolong heating time and reduce peak heating temperature. The present self-heating thermal-insulation film can be manufactured into a three-dimensional face mask, a face mask, or an eye mask.

A therapeutic wrap assembly includes a pouch that may be wrapped around a user's body. The pouch has an outer surface and the outer surface is matable to itself. Thus, the pouch is removably retained on the user's body. A gel is contained within the pouch. The gel may be heated and cooled thereby facilitating the pouch to provide therapeutic heat and therapeutic cooling.

The present invention is directed to a self regulating heater including a first layer made of a thin and flexible electrically insulating material. A second electrically conductive layer includes first and second buses spaced from each other. A third resistive layer electrically connects the first and second buses. The third layer has a higher electrical resistance than the second layer. The third layer experiences a positive temperature coefficient (PTC) effect when heated. A fourth interface layer directly connected to at least one of the second electrically conductive layer and the third resistive layer directly engages skin of a patient when the heater is attached to the patient. A combined thickness of the first layer, the second conductive layer, the third resistive layer and the fourth layer may be between 5 mil and 20 mil.

A therapeutic treatment device, system and method for improving administration of a temperature sensitive drug into a tissue on the body of a patient at a drug injection site are disclosed. The device includes a treatment element with a controllable heating element in temperature communicative contact with the tissue adjacent to the drug injection site. The controllable heating element is configured to heat the tissue adjacent to the drug injection site to a controllable temperature but does not heat the injected drug above a predetermined limiting temperature, above which degradation of the injected drug may occur.

Disclosed herein is a system, apparatus and method directed to an expandable and conformable targeted temperature management (TTM) pad. The system, apparatus and method pertain to a medical pad for exchanging thermal energy between a TTM fluid and a patient. The pad includes an insulating layer, a fluid containing layer for containing the TTM fluid, and a patient contact surface. The fluid containing layer is configured for circulating the TTM fluid. The patient contact surface defines a first patient contact area to facilitate thermal energy exchange with the patient. One or more slits are arranged in at least the insulating layer of the pad to facilitate stretching the pad and conforming to a contour of a patient's anatomy. The stretching can expand the patient contact surface to a larger second patient contact area. The pad can further include a flexible fabric cover.

Dry eye treatment apparatus and methods are described herein which generally includes a patch or strip affixed to the skin of the upper and/or lower eyelids to deliver heat or other forms of energy, pressure, drugs, moisture, etc. (alone or in combination) to the one or more meibomian glands contained within the underlying skin. The treatment strip or strips include one or more strips configured to adhere to an underlying region of skin in proximity to one or both eyes of a subject such that the one or more strips allow for the subject to blink naturally without restriction from the one or more strips. Moreover, the one or more strips may be configured to emit energy to the underlying region of skin and where the one or more strips are shaped to follow a location of one or more meibomiam glands contained within the underlying region of skin.

An improved medical pad for contact thermal exchange with a patient includes a fluid circulation layer for containing a thermal exchange fluid circulatable therethrough, a first port and a second port for circulating the thermal exchange fluid in to and out of the fluid circulation layer, and a hydrogel layer interconnected to and extending across one side of the fluid circulation layer to define an adhesive surface for adherence to a patient's skin. The hydrogel layer comprises an ultra violet light-cured composition that includes a cross-linking copolymer in an amount of between about 15% to 30% by weight of the composition, water in an amount of between about 15% to 40% by weight of the composition, and glycerol in an amount of between about 25% to 35% by weight of the composition. The hydrogel layer is provided to have a thermal conductivity of at least about 1.9 cal/hr-cm-° C.

The disposable eye patch further comprises a rim ember circumferentially attached to the second layer, wherein the rim member comprises an adhesive for sticking the eye patch to cover the human eye. The adhesive is a safe for contact with the human skin and can be easily removed and discarded after a single use. The disposable eye patch further comprises an absorbent layer attached to the first layer facing the outer surface of the eye.