Systems and methods are disclosed that relate to a stabilization and cooling apparatus having a stabilizing structure with at least one inflatable chamber, the stabilizing structure configured to become semi-rigid upon inflation of the at least one inflatable chamber. A cooling structure is integrated with the stabilizing structure and includes a single-use cooling element and a thermally conductive material in thermal communication with the single-use cooling element. The apparatus also has an actuator configured to cause inflation of at least one inflatable chamber.

A modular cooling pack and method of cooling a head of a patient includes a first pocket, a first cooling capsule, a second pocket, a second cooling capsule, a third pocket, a third cooling capsule, and a securement strap. Each of the first, second, and third cooling capsules are respectively configured to be received within the first, second, and third pockets, cooled, and applied to the head of the patient. The securement strap is configured to receive the first, second, and third pockets thereagainst and at least partially define a closed loop configured to be received about the head of the patient to thereby removably secure the first, second, and third pockets against the head of the patient in at least one of a plurality of assembled configurations.

Disclosed is an applicator device for an apparatus used in a localized cryotherapy treatment. The applicator device is configured, when positioned over a body area to be treated, to receive and to uniformly distribute across the entire area covered thereby a stream of medium, such as air, adjusted to a temperature equal to or above −40 degrees Celsius (° C.) and directed, at a predetermined speed, via the applicator to the area to be treated, whereby a cold-induced thermal shock response is developed in skin and an underlying tissue within the area covered by the applicator. Related apparatus and a method are further provided.

Therapeutic agent delivery devices are provided. Aspects of the devices include an active agent composition and an actuator configured to deliver the active agent composition to a target delivery site. In some instances, aspects of the devices include a syringe comprising a viscous active agent composition, a needle operably coupled to the syringe and an actuator configured to deliver viscous active agent composition from the syringe through the needed to a target delivery site, such as an intravitreal site. In some instances, aspects of the devices include a sleeve comprising a solid formulation of the active agent; a needle operably coupled to the sleeve; and an actuator configured to move the solid formulation from the sleeve and through the needle, e.g., to an intravitreal location. In some instances, aspects of the devices include a syringe containing a composition for subcutaneous delivery, a needle operably coupled to the syringe, a motorized actuator configured to deliver the composition from the syringe through the needle to a target subcutaneous site, and a pain mitigation system. Also provided are methods of using the devices.

Provided herein are methods of nerve blockage, for example for treatment of obesity, heart failure, cardiovascular disease, muscle spasms, chronic pain, or urinary retention in a patient. The method comprises first heating a nerve above physiological temperature (e.g., 37° C. in a human), such as from 43° C. to 54° C. for a duration that leads to reversible nerve blockage as opposed to nerve damage. Second, reversible nerve blockage is produced by cooling the nerve below physiological temperature to a temperature in which reversible nerve blockage is achieved, for example from 15° C. to 30° C.

Disclosed herein are systems and methods for visualizing a target anatomy of a patient in preparation of a medical procedure. A system can have transducers defining a grid to collect data about the target anatomy. A user interface (22014) can be disposed on area of the system to visualize the target anatomy. The visualization can include a virtual representation (22016) formed by an imager processor based on the data collected by the transducers. The method can include positioning the visualization device at an orientation where the transducers face the target anatomy. The method can further include adjusting the position of the visualization device to a target anatomy displayed on the virtual representation. The method can further include directing a medical instrument towards a target displayed on the virtual representation.

Disclosed herein are devices and methods for visualizing a target anatomy of a patient in preparation of a medical procedure. The device can include a pad having a conductive material. The pad can include an engaging element that can engage the conductive material to a medical imaging device. The method can include attaching the gel pad to a visualization device. The gel pad can contact the patient. The method can further include viewing the target anatomy using the visualization device. The visualization device can include transducers to collect data on the target anatomy and a user interface to visualize the target anatomy. A medical instrument can be directed into the gel pad and towards the target anatomy. A device can be provided to manage pain during the procedure. The device may include a stimulating element to decrease pain experienced by the patient.

Disclosed herein are systems and methods for visualizing a target anatomical site of a patient using one or more imagers. The method can include placing multiple imagers on multiple locations at an anatomical site. The method can further include generating separate image data sets from the multiple images and combining the image data sets to generate a volumetric imaging data of the anatomical site. The volumetric imaging data can include all anatomical features within the target anatomical site. A visualization system for medical imaging can include transducers on the imagers to visualize the target anatomical site. The system can further include a processor to combine the image data sets to generate the volumetric imaging data set. The system can further include a display device to display the volumetric imaging data set.

Disclosed herein is an apparatus for inserting a needle and a method for cannulation of a blood vessel. The apparatus can include a targeting assembly to identify a target location and an insertion path for the needle. The apparatus can further include a frame and insertion assembly to hold and place the needle. A user interface can be provided to provide feedback to an operator. The apparatus can include an adjustable band that engages a body portion of the patient. The method can include placing and securing the frame to the body portion. The method can further include locating the target location and inserting the needle through a target area.

The present invention provides a biphasic formulation, comprising a liquid layer on the outside and an elastic hydrogel wherein the water formed on the surface of the elastic gel is physically cooling the skin by evaporating and to give a first boost of the active ingredients directly when placing on the skin of humans or animals. The biphasic formulation according to the present invention may be arranged in a hydrogel patch which creates an environment that relieves or promotes the healing process for the treatment of insect bites, sunburn, erythema, pruritus, acne, dry skin or callus. In accordance with the present invention, there is provided a biphasic hydrogel composition, comprising 6% or less PVA, physical crosslinking, glycerol as humectant and the use of water impermeable packaging to reach equilibrium of the syneresis and preserve the moisture of the gel during long-term storage.