A nerve tissue stimulator configured for contacting to or insertion in the body of a subject to stimulate a tissue therein, said probe comprising: (a) a support configured for contacting to or positioning adjacent a tissue of said subject; (b) at least one thermoelectric device (TED) on said support and positioned for thermally stimulating said nerve tissue.

A method and system for treating restless leg syndrome. The system includes a vibration generator and a controller operable to provide counter-stimulation vibration to a patient suffering from restless leg syndrome. The counter-stimulation may be provided at a frequency of between 1 cycle/minute to 1000 cycles per second and at an amplitude and duration sufficient to act as a counter-stimulation vibration to restless leg syndrome but low enough to allow the patient to sleep.

A thermal device includes a first thermal unit, a second thermal unit, and device electronics. The first thermal unit includes a first plurality of semiconductor elements sandwiched between first and second thermal unit substrates. The first thermal unit substrate exchanges heat with a user. The second thermal unit includes a second plurality of semiconductor elements sandwiched between third and fourth thermal unit substrates. The third thermal unit substrate exchanges heat with the user. The device electronics are coupled to the first thermal unit and the second thermal unit. The device electronics operate the first thermal unit in a heating state in which the first thermal unit transfers heat to the user via the first thermal unit substrate. The device electronics operate the second thermal unit in a cooling state in which the second thermal unit removes heat from the user via the third thermal unit substrate.

In combined methods for treating a patient using time-varying magnetic field, treatment methods combine various approaches for aesthetic treatment. A magnetic field generating device is placed proximate to a body region of the patient. The magnetic field generating device generates a time-varying magnetic field with a magnetic flux density in a range of 0.5 to 7 Tesla. The time-varying magnetic field is applied to the body region of the patient in order to cause a contraction of a muscle within the body region. A second therapy may be used by applying one or more of optical waves, radio frequency waves, mechanical waves, negative or positive pressure or heat to the body region of the patient.

Wearable heat transfer devices and associated systems and methods are disclosed herein. In some embodiments, a representative heat transfer device can comprise (i) a thermoelectric component (TEC) including a first side configured to be operated at a desired temperature and a second side opposite the first side, (ii) a thermally conductive contact member thermally coupled to the TEC, and (iii) a heat transfer system configured to distribute heat from the TEC. The heat transfer system includes a heat transfer structure thermally coupled to the TEC, and a heat exchanger thermally coupled to the heat transfer structure.

Provided herein are methods of nerve blockage, for example for treatment of obesity, heart failure, cardiovascular disease, muscle spasms, chronic pain, or urinary retention in a patient. The method comprises first heating a nerve above physiological temperature (e.g. 37 C. in a human), such as from 43 C. to 54 C. for a duration that leads to reversible nerve blockage as opposed to nerve damage. Second, reversible nerve blockage is produced by cooling the nerve below physiological temperature to a temperature in which reversible nerve blockage is achieved, for example from 15 C. to 30 C.

The invention provides a device (1) for treating skin comprising a housing (100) and a skin treatment head (200) rotatable (around an axis element (500)) associated with said housing (100), wherein the housing (100) encloses an actuator configured to rotate said skin treatment head (200), wherein the skin treatment head (200) comprises one or more brushes (210) associated with a support element (220), wherein the device (1) further comprises a first thermally conductive element (310), wherein the first thermally conductive element (310) is configured at a shortest distance (d1) to the one or more brushes (210) selected from the range of 0-40 mm, and wherein the device (1) comprises a thermoelectric element (300) configured to heat in a first mode said first thermally conductive element (310) to provide a hot surface (311).

Systems and methods for manipulating the temperature of a surface are described. Described embodiments include thermal adjustment devices that may include a heatsink and that are operated in two or more modes of operation to apply a desired temperature to a user. In one operating mode the thermal adjustment device may apply a first temperature to an underlying surface while generating heat at a rate faster than the heatsink's heat dissipation rate. The thermal adjustment device may then apply a second temperature to reduce the rate of heat generation to be less than the heatsink's heat dissipation rate. These modes of operation may be applied cyclically to permit continuous operation of the thermal adjustment device. In some embodiments, the temperature profile applied when changing between the modes of operation may be selected such that the user experiences either a reduced, or substantially, neutral thermal sensation.

A personal microclimate control system for sensing cutaneous conditions on a body. The sensors are located on spatially distinct physical locations on a body, adjacent to the cutaneous layer. A controller and connected memory stores the addresses for the sensors. The controller operates the sensors based on their addresses for the purpose of improving thermal comfort. In an embodiment, the controller controls the sensors by executing multiple-input multiple output algorithms. Embodiments are further directed to controlling a plurality of individual electronic effectors as well as to improving system safety, usability and management capabilities.

The systems and methods in accordance with the principles of the invention can promote correction of an aesthetic or functional defect in a target tissue. A method can include non-invasively applying a cooling agent to a surface of a target tissue; and cooling one or more tissue layers of said target tissue to a predetermined therapeutic temperature, wherein applying the cooling agent is performed such that cryoablation of said one or more layers of the target tissue does not occur. The system can include: a controller and a probe having a distal end configured for non-invasive contact with a surface of a target tissue to cool the target tissue based on treatment parameters.