Disclosed are systems, devices and methods for laser microporation for rejuvenation of tissue of the eye, for example, regarding aging of connective tissue and rejuvenation of connective tissue by scleral rejuvenation. The systems, devices and methods disclosed herein restore physiological functions of the eye including restoring physiological accommodation or physiological pseudo-accommodation through natural physiological and biomechanical phenomena associated with natural accommodation of the eye. In some embodiments, the laser system may be configured to treat ocular tissue off axis or in a region of the eye which is distinct from the visual axis or directed away from the pupil of the eye where the gaze of the eye is.

An ophthalmic laser system for generating a first beam at a first wavelength on a first beam path and a second beam at a second wavelength on a second beam path, and directing optics to selectively direct the first beam or the second beam to a treatment beam path. The ophthalmic laser system incorporates a reflex coaxial illuminator comprising a reflex mirror movable on an axis from a position out of the treatment beam path to a position in the treatment beam path to direct illumination into an illumination path coaxial with the treatment beam path. The reflex mirror is adapted to transmit a beam that follows the second beam path.

A movable illumination tower for use with a photodisruptor that provides titratable illumination of ocular tissue. The illumination tower can be rotated between an on-axis position relative to the photodisruptor axis and an off-axis position relative to the photodisruptor axis, such that the illumination tower is positioned at an angle relative to the photodisruptor axis under the control of a hands-free motor.

A system for treating a media opacity in a vitreous media of an eye includes a visualization module adapted to provide visualization data of a portion of the eye via one or more viewing beams. The system includes a laser module adapted to selectively generate a treatment beam directed towards the media opacity in order to disrupt the media opacity. The laser module and the visualization module have a shared aperture for guiding the treatment beam and the one or more viewing beams towards the eye, the shared aperture being centered about a central axis. A controller is configured to acquire one or more defining parameters of the media opacity and determine when the media opacity is with a predefined target zone of a real-time viewing window. The media opacity is treated with the treatment beam when the media opacity is within the predefined target zone.

A method for altering an eye color of a patient with a color alteration procedure is disclosed that may include imaging the iris with an image sensor prior to the color alteration procedure to generate an image of the iris. A mapping of the iris may be generated from the image. The mapping may include a number of regions corresponding to varying absorption coefficients of a treatment wavelength in the stromal pigment of the iris. A laser system may be set, based on the mapping, to deliver laser light at a laser power sufficient to cause elimination of at least a portion of stromal pigment in the iris. The laser light may then be delivered with the laser system.

In certain embodiments, an ophthalmic laser surgical system for imaging and treating a target in an eye includes an optical coherence tomography (OCT) device that: directs an imaging beam towards the eye; generates three-dimensional (3D) image data from the imaging beam reflected from the eye; and generates two-dimensional (2D) enface images from the 3D image data. The 2D enface images include a target enface image imaging the target in the eye and a retinal enface image imaging a shadow cast by the target onto the retina. An xy-scanner directs the imaging beam along an imaging beam path towards the eye, and directs a laser beam from the laser device along a laser beam path aligned with the imaging beam path towards the eye. A computer compares the target of the target enface image and the shadow of the retinal enface image to confirm the presence of the target.

An apparatus for aiding the removal of cataracts in which an optical fiber delivers sufficient optical energy of the correct wavelength, pulse duration to achieve controlled non-thermal and non-acoustic dissolution of hard cataract tissue.

A target volume of ocular tissue is treated with a laser having a direction of propagation toward the target volume, where the target volume is characterized by a distal extent, a proximal extent, and a lateral extent. A layer of tissue at an initial depth corresponding to the distal extent of the target volume is initially photodisrupted using a femtosecond laser by scanning the laser in multiple directions defining an initial treatment plane. Tissue at one or more subsequent depths between the distal extent of the target volume and the proximal extent of the target volume is subsequently photodisrupted using a femtosecond laser by moving a focus of the laser in a direction opposite the direction of propagation of the laser and then scanning the laser in multiple directions defining a subsequent treatment plane. Photodisruption is repeated at different subsequent depths until tissue at the proximal extent of the target volume is photodisrupted.

In certain embodiments, an ophthalmic system includes an anamorphic depth gauge (ADG) device and a computer. The ADG device measures the z-location in the interior of an eye and includes a detector array arranged at an oblique angle with respect to the z-axis. The array generates a detector signal in response to detecting a light beam, which has a z-focus in the interior of the eye. A set of line focus optical elements focuses the light beam to form a line focus on the detector array, and a set of nominal focus optical elements focuses the light beam to form a nominal focus on the detector array. The computer: generates an image using the detector signal; determines the position of the nominal focus on the line focus according to the image; and determines the z-location of the z-focus from the position of the nominal focus on the line focus.

The present disclosure generally relates to microsurgical instruments for ophthalmic surgical procedures, and more particularly, methods and microsurgical instruments for vitreoretinal procedures. In certain embodiments described herein, a vitreoretinal procedure is performed utilizing two surgical instruments: 1) a treatment instrument configured to a) treat a target ophthalmic tissue (e.g., sever and remove the vitreous body), and b) infuse fluid into the intraocular space to maintain intraocular pressure (IOP); and 2) an illumination probe for providing illumination within the intraocular space. The combined treatment and infusion functionalities of the treatment instrument eliminate the need for a separate infusion cannula, thus enabling the vitreoretinal procedure to be performed with only two instruments and reducing the number of incisions made in the eye. Additionally, utilization of two instruments facilitates easier manipulation of the eye by a surgeon, as one of the two instruments can be used to steer the eye during the procedure.