Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.

Methods and related apparatus for real-time process monitoring during laser-based refractive index modification of an intraocular lens. During in situ laser treatment of the IOL to modify the refractive index of the IOL material, a signal from the IOL is measured to determine the processing effect of the refractive index modification, and based on the determination, to adjust the laser system parameters to achieve intended processing result. The signal measured from the IOL may be a fluorescent signal induced by the treatment laser, a fluorescent signal induced by an external illumination source, a temporary photodarkening effect, a color change, or a refractive index change directly measured by phase stabilized OCT.

A device for fusing two or more tissues is disclosed. The device comprises a hand held probe comprising a fluid receiving opening, a channel and an outlet in fluid communication whereby fluid passes through the channel and exits the outlet where it is directed to at least one of the two or more tissues and/or a space in-between. A disruptive emitter, in the form of a laser, is comprised on the probe which emits a force sufficient to fuse the two or more tissues. The device finds particular application to treatment of a detached retina by fusing the retina and the retinal pigmented epithelium. A method of fusing two or more tissues including a retina and underlying retinal pigmented epithelium is also disclosed.

A laser eye surgery system that has a patient interface between the eye and the laser system relying on suction to hold the interface to the eye. The patient interface may be a liquid-filled interface, with liquid used as a transmission medium for the laser. During a laser procedure various inputs are monitored to detect a leak. The inputs may include a video feed of the eye looking for air bubbles in the liquid medium, the force sensors on the patient interface that detect patient movement, and vacuum sensors directly sensing the level of suction between the patient interface and the eye. The method may include combining three monitoring activities with a Bayesian algorithm that computes the probabilities of an imminent vacuum loss event.

A system and apparatus for increasing the amplitude of accommodation and/or changing the refractive power and/or enabling the removal of the clear or cataractous lens material of a natural crystalline lens is provided. Generally, the system comprises a laser, optics for delivering the laser beam and a control system for delivering the laser beam to the lens in a particular pattern. There is further provided a range determining system for determining the shape and position of the lens with respect to the laser. There is yet further provided a method and system for delivering a laser beam in the lens of the eye in a predetermined shot pattern.

A magnetic positioning system and related method for automated or assisted eye-docking in ophthalmic surgery. The system includes a magnetic field sensing system on a laser head and a magnet on a patient interface to be mounted on the patient's eye. The magnetic field sensing system includes four magnetic field sensors located on a horizontal plane for detecting the magnetic field of the magnet, where one pair of sensors are located along the X direction at equal distances from the optical axis of the laser head and another pair are located along the Y direction at equal distances from the optical axis. Based on relative magnitudes of the magnetic field detected by each pair of sensors, the magnetic field sensing system determines whether the patient interface is centered on the optical axis. The system controls the laser head to move toward the patient interface until the latter is centered on the optical axis.

A lens/sensor subassembly (318) may include a feedback sensor (324), a data transmission line (302), and an electrical element (328). The feedback sensor (324) may be configured to measure a phenomenon in an eye (100) of a patient during a laser-based ophthalmological therapy. The data transmission line (302) may be configured to communicate feedback data measured by the feedback sensor (324) to a laser-based ophthalmological treatment system (200). The electrical element (328) may be degradable in response to exposure to therapeutic radiation (316). The degradation of the electrical element (328) may interrupt communication of the feedback data measured by the feedback sensor (324) to the laser-based ophthalmological treatment system (200).

Calibration of laser pulse powers used to form subsurface optical structures in an ophthalmic lens is accomplished via generation of a feedback signal indicative of pulse energy absorption. A system for forming subsurface optical structures within an ophthalmic lens includes a laser pulse source, a laser pulse power control assembly, a scanning assembly, a detector, and a control unit. The laser pulse power control assembly is operable to selectively control an energy of respective laser pulses. The detector is configured to generate a feedback signal indicative of an energy absorbed by the ophthalmic lens from a first laser pulse. The control unit is configured to control operation of the laser pulse power control assembly to selectively control an energy of a second laser pulse based on a selected energy of the second laser pulse, a selected energy of the first laser pulse, and the feedback signal.

In some embodiments, an ophthalmic laser system may be provided that does not include a traditional laser console. Instead, the treatment device may be configured to house the treatment light source within the device handle. Additionally, in some embodiments, the handheld treatment device may include a user interface, such as dials and buttons, for adjusting various parameters of the therapeutic light. With certain embodiments, the self-contained handheld treatment device may be operated independent of an AC power source. For example, in some embodiments, the handheld treatment device may be battery powered. Additionally, the handheld treatment device may be disposable or may utilize replaceable distal tips in certain embodiments. Certain embodiments may be particularly designed for transscleral cyclophotocoagulation. Also, treatment guides are provided that may be configured to couple with a treatment device to align the device with a target tissue of the eye.

Generation of treatment recommendations for topographic-based excimer laser surgical procedures is described that includes generating accurate cylinder compensation and spherical compensation values that are adjusted to compensate for unique characteristics of advanced topographic-based excimer laser surgical systems. Generating treatment recommendations generally includes determining a topographic vector from a topographic corneal map of the eye, determining a posterior astigmatism vector and an anterior astigmatism vector for the eye, and generating an interior astigmatism vector using the topographic vector, the posterior astigmatism vector, the anterior astigmatism vector, and a manifest astigmatism vector. In various embodiments, the cylinder compensation is generated using the interior astigmatism vector and the posterior astigmatism vector, and the spherical compensation is generated using an initial spherical compensation modified by a topographic addback modifier and a cylinder addback modifier.