A laser system is calibrated with a tomography system capable of measuring locations of structure within an optically transmissive material such as a tissue of an eye. Alternatively or in combination, the tomography system can be used to track the location of the eye and adjust the treatment in response to one or more of the location or an orientation of the eye. In many embodiments, in situ calibration and tracking of an optically transmissive tissue structure such as an eye can be provided. The optically transmissive material may comprise one or more optically transmissive structures of the eye, or a non-ocular optically transmissive material such as a calibration gel in a container or an optically transmissive material of a machined part.

A method that includes illuminating an eye with light at a first time and a second time and generating a first image of the eye based on the light that illuminates the eye at the first time. The method includes generating a second image of the eye based on the light that illuminates the eye at the second time. The method further includes positioning a laser source relative to the eye, wherein the laser source generates a therapeutic laser beam to be directed to the eye, wherein the first time is just prior to the therapeutic laser beam being directed to the eye and the second time is prior to the first time. The method further includes correcting orientation of the laser source relative to the eye based on a correlation function that is defined for the first and second images of the eye.

In a laser cataract procedure that also corrects for astigmatism, an iris registration method compares an iris image of a patient's eye taken when the eye is not docked to a patient interface device with an iris image of the same eye that is docked to the patient interface, to calculate a rotation angle between the two images. The astigmatism axis of the eye is measured when the eye is not docked, and the measured axis is rotated by the calculated rotation angle to obtain a rotated astigmatism axis relative to the iris image of the docked eye. The laser cataract procedure is performed based on the rotated astigmatism axis. The rotation angle is calculated by optimizing a transformation that transforms the undocked iris image to match the docked iris image, where the transformation includes a dilation factor that accounts for different pupil dilation of the two iris images.

A target volume of ocular tissue of an irido-corneal angle of an eye is treated by moving a focus of a laser through the target volume of ocular tissue, and photodisrupting the target volume of ocular tissue at a plurality of spots as the focus is moved through the target volume of ocular tissue. The focus is moved by transverse scanning the focus between at least one of: a first circumferential boundary and a second circumferential boundary of the target volume of ocular tissue, and a first azimuthal boundary and a second azimuthal boundary of the target volume of ocular tissue, and axial scanning the focus between a distal extent and a proximal extent of the target volume of ocular tissue.

A system for guiding an ophthalmic procedure is disclosed. The system includes a housing assembly with a head unit configured to be at least partially directed towards a target site in an eye. An optical coherence tomography (OCT) module and stereoscopic visualization camera are at least partially located in the head unit and configured to obtain a first set and a second set of volumetric data, respectively. A controller is configured to register the first set and second set of volumetric data to create a third set of registered volumetric data. The third set and second set of registered volumetric data are rendered, via a volumetric render module, to a first and second region. The first region and the second region are overlaid to obtain a shared composite view of the target site. The controller is configured to extract structural features and/or enable visualization of the target site.

A method is disclosed for determining a current position of a patient interface of an eye surgical laser for an eye relative to an optical axis of a laser beam of a treatment apparatus. The method includes determining a target position of the patient interface relative to the optical axis, positioning the patient interface in a preset area in front of the optical axis, illuminating the patient interface by means of an illumination device, capturing a Purkinje image by means of the optical capturing device, comparing the captured Purkinje image to the optical axis and determining the current position of the patient interface depending thereon, comparing the current position to the target position and with a deviation, and outputting a control signal to a control device of the treatment apparatus. A treatment apparatus, a computer program and a computer-readable medium are disclosed for carrying out the method.

The invention provides an excimer laser system including a means for calibrating laser output to compensate for increased variation in laser optical fibers.

A laser system calibration method and system are provided. In some methods, a calibration plate may be used to calibrate a video camera of the laser system. The video camera pixel locations may be mapped to the physical space. A xy-scan device of the laser system may be calibrated by defining control parameters for actuating components of the xy-scan device to scan a beam to a series of locations. Optionally, the beam may be scanned to a series of locations on a fluorescent plate. The video camera may be used to capture reflected light from the fluorescent plate. The xy-scan device may then be calibrated by mapping the xy-scan device control parameters to physical locations. A desired z-depth focus may be determined by defining control parameters for focusing a beam to different depths. The video camera or a confocal detector may be used to detect the scanned depths.

A method for measuring the intraocular pressure (IOP) of an eye docked to an ophthalmic surgical laser system via a patient interface assembly. While the eye is docked to the laser system, and as the vertical force exerted on the eye by the patient interface fluctuates as the patient breaths and moves, the amount of corneal deformation is continuously measured by an optical coherence tomography device of the laser system and the force exerted on the eye is continuously measured by force sensors integrated in the patient interface assembly. Based on the real-time force signal and real-time corneal deformation signal, a controller calculates a linear relationship between force and corneal deformation, and determines the IOP of the docked eye by comparing a slope of the linear relationship against a pre-established slope vs. IOP calibration curve. The IOP of the docked eye can be used when setting laser treatment parameters.

Systems and methods are provided for in vivo pre-surgical characterization of lenses, such as cataractous lenses. A method comprises obtaining an electromagnetically-measured value related to the axial thickness of the lens, obtaining an ultrasound-measured value related to the axial thickness of the lens, calculating a relationship value based upon the electromagnetically-measured value and the ultrasound-measured value, and determining a mechanical property value based upon the calculated relationship value. The mechanical property may relate to lens hardness, rigidity, or density, or the amount of energy for a phacoemulsification procedure. A system may comprise an optical interferometer for measuring data to obtain the electromagnetically-measured value and an ultrasound biometer for measuring data to obtain the ultrasound-measured value.