Systems and methods for sterilizing a column assembly including a column having an interior containing a retaining media and a parent radionuclide retained by the retaining media, an inlet port in fluid communication with the interior of the column, and an outlet port in fluid communication with the interior of the column. The method includes sealing at least one of the inlet port and the outlet port to form a sealed column assembly such that fluid communication with the column interior though both the inlet port and the outlet port is prevented, and sterilizing the sealed column assembly to form a terminally-sterilized column assembly.

A system includes a radiation containment chamber, an isolator connected to the radiation containment chamber, a rotating transfer door positioned between the radiation containment chamber and the isolator, and an antimicrobial vapor generator connected to the isolator. The rotating transfer door includes a cavity for receiving a radionuclide generator column assembly, and is rotatable between a first position, in which the cavity is open to the radiation containment chamber, and a second position, in which the cavity is open to the isolator. The transfer door is adapted to rotate while antimicrobial vapor is introduced into the isolator by the antimicrobial vapor generator.

Methods for purifying .sup.89Zr are provided, .sup.89Zr compositions are provided, isotope compositions are provided that can include: a radio isotope and a nanoparticle, and methods for radio labeling monoclonal antibodies are provided.

Methods for purifying .sup.89Zr are provided, .sup.89Zr compositions are provided, isotope compositions are provided that can include: a radio isotope and a nanoparticle, and methods for radio labeling monoclonal antibodies are provided.

An initial introduction control part introduces an aqueous solution containing molybdenum 99 and technetium 99m, and an organic solvent being capable of dissolving the technetium 99m into an extraction tank. A micro-mixing control part micro-mixes the aqueous solution and the organic solvent by heating and stirring a mixed solution of the aqueous solution and the organic solvent introduced into the extraction tank with a heater, while applying ultrasonic to the mixed solution. A separation control part separates the mixed solution micro-mixed into two phases of aqueous solution and an organic solvent. A taking-out introduction control part passes the organic solvent separated into two phases through an adsorption column be capable of adsorbing molybdenum 99 and introduces the organic solvent into an evaporation elution tank. An evaporation control part evaporates the organic solvent and leaves residue by reducing pressure inside the evaporation elution tank and heating the organic solvent introduced into the evaporation elution tank with a heater, while applying ultrasonic to the organic solvent. An elution control part introduces physiological saline solution into the residue and elutes technetium 99m into the physiological saline solution from the residue.

This disclosure provides systems, methods, and apparatus related to the production of actinium-225. In one aspect, a target is irradiated with a beam of deuterons to generate a beam of neutrons. A radium-226 target is irradiated with the beam of neutrons to generate radium-225.

This disclosure provides systems, methods, and apparatus related to the production of actinium-225. In one aspect, a target is irradiated with a beam of deuterons to generate a beam of neutrons. A radium-226 target is irradiated with the beam of neutrons to generate radium-225.

A pierceable plug for closing off a piercing end of a needle is described herein. The plug has an end that is configured to be pierced by the needle to close off the piercing end of the needle. The plug may be radiation sterilizable and may be made of a material that includes an antimicrobial agent. The plug may be used to close off a needle end that is in fluid communication with a radioactive substance.

A pierceable plug for closing off a piercing end of a needle is described herein. The plug has an end that is configured to be pierced by the needle to close off the piercing end of the needle. The plug may be radiation sterilizable and may be made of a material that includes an antimicrobial agent. The plug may be used to close off a needle end that is in fluid communication with a radioactive substance.

An isotope production system, emanation generator, and process are disclosed for production of high-purity radioisotopes. In one implementation example, high-purity Pb-212 and/or Bi-212 isotopes are produced suitable for therapeutic applications. In one embodiment the process includes transporting gaseous radon-220 from a radium-224 bearing generator which provides gas-phase separation of the Rn-220 from the Ra-224 in the generator. Subsequent decay of the captured Rn-220 accumulates high-purity Pb-212 and/or Bi-212 isotopes suitable for direct therapeutic applications. Other high-purity product isotopes may also be prepared.