An optical imaging system includes an optical radiation source (410, 510), a frequency clock module outputting frequency clock signals (420), an optical interferometer (430), a data acquisition (DAQ) device (440) triggered by the frequency clock signals, and a computer (450) to perform multi-dimensional optical imaging of the samples. The frequency clock signals are processed by software or hardware to produce a record containing frequency-time relationship of the optical radiation source (410, 510) to externally clock the sampling process of the DAQ device (440). The system may employ over-sampling and various digital signal processing methods to improve image quality. The system further includes multiple stages of routers (1418, 1425) connecting the light source (1410) with a plurality of interferometers (1420a-1420n) and a DAQ system (1450) externally clocked by frequency clock signals to perform high-speed multi-channel optical imaging of samples.

Disclosed herein are optical integration technologies, designs, systems and methods directed toward Optical Coherence Tomography (OCT) and other interferometric optical sensor, ranging, and imaging systems wherein such systems, methods and structures employ tunable optical sources, coherent detection and other structures on a single or multichip monolithic integration. In contrast to contemporary, prior-art OCT systems and structures that employ simple, miniature optical bench technology using small optical components positioned on a substrate, systems and methods according to the present disclosure employ one or more photonic integrated circuits (PICs), use swept-source techniques, and employ a widely tunable optical source(s). In another embodiment the system uses an optical photonic phased array. The phase array can be a static phased array to eliminate or augment the lens that couples light to and from a sample of interest or can be static and use a spectrally dispersive antenna and a tunable source to perform angular sweeping. The phased array can be active in 1 or 2 dimensions so as to scan the light beam in angle. The phased array can also adjust focus. The phased array can implement an optical waveform that will extend depth of field focus for imaging. The phase array can also be a separate standalone element that is fed by one or more optical fibers. The phased array can be for scanning a biomedical specimen used in conjunction with a swept-source OCT system, can be used in a free-space coherent optical communication system for beam pointing or tracking, used in LIDAR applications, or many other beam control or beam steering applications.

An optical coherence tomographic device may include a light source, a measurement light generator, a reference light generator, an interference light generator, an interference light detector, and a processor. The interference light detector may include a first and second detector that convert interference light to interference signals, a first signal processing unit that samples the interference signal from the first detector, and a second signal processing unit that samples the interference signal from the second detector. Each of the first and second signal processing units may sample the interference signal at a timing from outside. Light generated by the measurement light generator may at least include first and second correction light. The processor may correct a time lag between sampling timings of the first and second signal processing units by using a first and second correction signal converted from the first and second correction light.

An optical coherence tomography (OCT) system electrically mixes a signature signal with an OCT signal (e.g., an interferogram) output by a photodetector of the OCT system. The signature signal may be a signal output by a photodetector that detects an optical signal from a fiber Bragg grating. The signature signal may then be time delayed before combination with the OCT signal. A series of interferograms are then aligned according to the signature signal. A rescaling signal may be similarly electrically mixed with the signature and OCT signals.

The present application in some embodiments relates to methods for reducing noise and/or clutter when measuring a spectrum, particularly but not only for OCT imaging. In some embodiments a light source is synchronized with a detector. For example a narrow band light source is synchronized with a narrow band detector. For example, the light source may scan over multiple frequency bands and/or the detector may be tuned to a frequency band synergetic to the band of the light source. For example the light source and detector may be tuned to overlapping narrow bands. Optionally the detector has a sensor set for each frequency band. Optionally some sensor sets are individually resettable. For example each set may have a reset circuit. For example, a sensor set for a band not currently being measured is deactivated.

An optical coherence tomography includes a light source, a light separator, a light generator configured to generate interference light, a detector configured to detect the interference light, a first optical element, and at least one of second optical elements comprising a pair of surfaces, and performs forming a tomographic image of a subject. The first optical element is arranged on a measurement light path so as to be closest to the subject, and satisfies at least one of following conditional formulas:

−(W−S)<U−2Z<X−W;   [a2]

U−2Z<−W; and   [b1]

U−2Z>X−W+S,   [c2] W: a predetermined operation distance U: a depth of interest S: a range of interest X: a distance which is greater than W+U+S and minimal among distance(s) between the pair of surfaces Z: a shallowest position of the area of interest relative to an origin position.

An optical coherence tomograph includes a wavelength tunable illuminating device, an illumination and measurement beam path with a dividing element and a scanner and a front optical unit and a reference beam path, a detection beam path and a flat panel detector. A beam splitter conducts the separated measurement radiation to the detection beam path and an optical element acts only on the illumination radiation. The optical element sets the numerical aperture of the illumination of the illumination field in the eye. An optical element acts only on the measurement radiation and sets the numerical aperture with which measurement radiation is collected in the eye. An aperture is arranged in front of the flat panel detector in an intermediate image plane and defines the size of an object field. The flat panel detector has a spatial resolution of 4 to 100 pixels in a direction.

En face views of OCT volumes provide important and complementing visualizations of the retina and optic nerve head investigating biomarkers of diseases affecting the retina. We demonstrate the combination of real time processing of OCT volumetric data for axial tracking. In combination with a Controllable Optical Element (COE), this invention demonstrates acquisition, real time tracking, automated focus on depth resolved en face layers extracted from a volume, and focus stacked OCT volumes with high resolution throughout an extended depth range.

Various optical systems equipped with diode laser light sources are discussed in the present application. One example system includes a diode laser light source for providing a beam of radiation. The diode laser has a spectral output bandwidth when driven under equilibrium conditions. The system further includes a driver circuit to apply a pulse of drive current to the diode laser. The pulse causes a variation in the output wavelength of the diode laser during the pulse such that the spectral output bandwidth is at least two times larger than the spectral output bandwidth under the equilibrium conditions.

Various optical systems equipped with diode laser light sources are discussed in the present application. One example system includes a diode laser light source for providing a beam of radiation. The diode laser has a spectral output bandwidth when driven under equilibrium conditions. The system further includes a driver circuit to apply a pulse of drive current to the diode laser. The pulse causes a variation in the output wavelength of the diode laser during the pulse such that the spectral output bandwidth is at least two times larger than the spectral output bandwidth under the equilibrium conditions.