The present invention aims to obtain a tomographic image free from image noise due to reflection on a container wall surface and having a good image quality by a simple configuration. In a FD-OCT imaging apparatus which images an imaging object stored in a container having an optical transparent wall part tomographically, when the focal depth is set such that a distance D from a first surface Sa of the wall part on the side of the imaging object to a focal point FP of the objective optical system is smaller than a predetermined threshold value smaller than a thickness T of the wall part, the distance between a second surface Sb of the wall part on a side opposite to the imaging object out of the wall surfaces and a reference plane which is perpendicular to the optical path of the illumination light and to which an optical path length is equal is set a value equal to the thickness of the wall part.

Retinal imaging systems and related methods employ a user specific approach for controlling the reference arm length in an optical coherence tomography (OCT) imaging device. A method includes restraining a user's head relative to an OCT imaging device. A reference arm length adjustment module is controlled to vary a reference arm length to search a user specific range of reference arm lengths to identify a reference arm length for which the OCT image detector produces an OCT signal corresponding to the retina of the user. The user specific range of reference arm lengths covers a smaller range of reference arm lengths than a reference arm length adjustment range of the reference arm length adjustment module.

An OCT apparatus includes an OCT optical system that has a light splitter splitting light from an OCT light source to light travelling to a measurement light path and light travelling to a reference light path and a detector detecting a spectrum interference signal of measurement light guided to a subject eye through the measurement light path and reference light from the reference light path, and a processing unit that processes the spectrum interference signal to generate OCT data. The processing unit performs at least complementary processing on an overlapping region of a real image and a virtual image in OCT data based on a plurality of OCT data obtained with different optical path lengths when detecting the spectrum interference signal, and generates OCT data subjected to the complementary processing.

An interferometric optical system for measuring a test object, including: i) a reference object comprising a partially reflective reference surface; ii) a light source module configured to direct first and second input beams through the reference surface to the test object at an angle to one another; iii) a detector positioned to detect light reflected from the reference surface and one or more surfaces of the test object; and iv) an aperture positioned to selectively block light from reaching the detector, wherein the angle between the first and second input beams causes the aperture to block light from the first input beam reflected by the reference surface and pass light from second input beam reflected by the reference surface, wherein the two input beams have a mutual coherence length smaller than twice an optical distance between the reference surface and the test object.

Aspects of the disclosure relate to systems, methods, and algorithms to perform wavenumber linearization and dispersion correction in optical systems without the need for hardware modifications, empirical adjustments, precise mirror alignment, and which can be conducted at low computational costs and in real-time. A one-time calibration process can generate spectra or calibration criteria, including wavenumber-linearization criteria, dispersion correction, and spectral flattening spectra, which can be used to correct an optical coherence tomogram in real time.

The present disclosure relates to a method of correcting a three-dimensional image. To correct an image distorted by coherence gate curvature (CGC) occurring by an optical system, the method generates a three-dimensional image of a sample holder on which an object to be measured is placed from an interference signal, generates a CGC profile on the basis of an image of a cover glass of the sample holder appearing in the three-dimensional image, generates a CGC fitting curve from the CGC profile, and corrects the interference signal by using the CGC fitting curve. The present disclosure also relates to an OCT system capable of performing a method of correcting a three-dimensional image.

The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity.

Retinal imaging systems and related methods employ a user specific approach for controlling the reference arm length in an optical coherence tomography (OCT) imaging device. A method includes generating a signal indicative of a position of a feature of a user's head relative to an OCT imaging device. A user specific reference arm adjustment length range for the user within a reference arm adjustment length range of the OCT device is determined based on the signal. A reference arm length adjustment module is controlled during an imaging of the retina to vary a reference arm length of the OCT imaging device within the user specific reference arm adjustment length range to identify an imaging reference arm length for which an OCT image detector of the OCT imaging device produces an OCT signal corresponding to the retina of the user.

One or more devices, systems, methods and storage mediums for performing optical coherence tomography (OCT) while reducing and/or eliminating crosstalk noise are provided. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes, catheters, capsules and needles (e.g., a biopsy needle). Preferably, the OCT devices, systems methods and storage mediums include or involve a method, such as, but not limited to, a complex conjugate method or a shift method, for handling the crosstalk noise in a way to mitigate or eliminate the noise from an image field of view. For example, a reference reflection or reference arm may be positioned or re-positioned in the image field of view at different locations depending on the crosstalk noise mitigation method being employed.

An imaging apparatus images an imaging object which is stored in a container having an optical transparent wall part tomographically via the wall part. An FD-OCT imaging apparatus sets an optical path length of a reference light in conjunction with a setting of a focal depth such that a position corresponding to the focal depth is between a position conjugate with a first surface and a position conjugate with a second surface in a reflected light intensity distribution representing a relationship between a position in an incident direction of an illumination light and a reflected light intensity. Here, the first surface is a surface on the imaging object side out of surfaces of the wall part. The second surface is another surface on a side opposite to the imaging object out of the surfaces of the wall part.