A spectroscopy system that includes a light source that generates light having a plurality of wavelengths, a light transmitter that transmits the light to a target analyte, a light receiver that receives Raman-scattered light scattered from the target analyte, and a multi-wavelength spectroscopy assembly that acquires a spectrum by splitting the Raman-scattered light transmitted from the light receiver. The multi-wavelength spectroscopy assembly includes a single diffraction grating configured to diffract the Raman-scattered light and a single concave mirror configured to focus the Raman-scattered light.

The invention provides methods and apparatus comprising a multi-wavelength laser source that uses a single unfocused pulse of a low intensity but high power laser over a large sample area to collect Raman scattered collimated light, which is then Rayleigh filtered and focused using a singlet lens into a stacked fiber bundle connected to a customized spectrograph, which separates the individual spectra from the scattered wavelengths using a hybrid diffraction grating for collection onto spectra-specific sections of an array photodetector to measure spectral intensity and thereby identify one or more compounds in the sample.

In an example, an Echelle grating wavelength division multiplexing (WDM) device includes a first waveguide, a slab waveguide, multiple second waveguides, an Echelle grating, and a metal-filled trench. The first waveguide includes either an input waveguide or an output waveguide. The multiple second waveguides are optically coupled to the first waveguide through the slab waveguide. The multiple second waveguides include multiple output waveguides if the first waveguide includes the input waveguide or multiple input waveguides if the first waveguide includes the output waveguide. The Echelle grating includes multiple grating teeth formed in the slab waveguide. The metal-filled trench forms a mirror at the grating teeth to reflect incident light from the first waveguide toward the multiple second waveguides or from the multiple second waveguides toward the first waveguide.

The invention provides a method for chemical signature resolved detection of a concealed object within a system. The method includes irradiating the system at a plurality of positions with aplurality of electromagnetic radiation of specific wavelength; capturing a certain component of the scattered electromagnetic radiation from the object at a plurality of locations along various 3D planes around the system; obtaining a plurality of profiles from the captured component of the scattered electromagnetic radiation; filtering the profiles to obtain a chemical signature specific to the object; and resolving the chemical signatures to detect the concealed object, wherein, the step of detection includes determination of the shape, size and location of the object.

The present disclosure provides for a Raman probes and methods of imaging including a Raman probe. The Raman probes include a Raman detection system configured to illuminate an area of a subject or a sample with a light source and to receive Raman scattered light energy from the area. The Raman probe can include a proximity sensor system and a fluorescent imaging system. A method of imaging introduces a Raman probe to a subject. Fluorescent light is detected from an area of the subject, which guides the Raman probe to the area. The Raman probe is positioned at a target distance from the area using the proximity sensor system, and by exposing the area to a light beam from the Raman detection system. The light beam, Raman scattered light energy, is scattered by a Raman agent associated with the area. Raman scattered light is detected using the Raman imaging device.

Problem: To provide an observation auxiliary device that can appropriately and readily perform observation using an exciting light as a light source.

Resolution Means: Provided are an imaging unit 104 that uses a light emitted from a second beam splitter 202 of a microscope 2 that can use an exciting light and an observation light, which is a light including a wavelength other than that of the exciting light, as a light source by switching there between and is provided with the second beam splitter 202 to image images of the same observation region of the microscope 2 in situations where the exciting light and the observation light are used as the light source and an output unit 106 that overlaps, synthesizes, and outputs the images imaged by the imaging unit 104 respectively using the exciting light and the observation light as the light source.

The invention provides methods and apparatus comprising a multi-wavelength laser source that uses a single unfocused pulse of a low intensity but high power laser over a large sample area to collect Raman scattered collimated light, which is then Rayleigh filtered and focused using a singlet lens into a stacked fiber bundle connected to a customized spectrograph, which separates the individual spectra from the scattered wavelengths using a hybrid diffraction grating for collection onto spectra-specific sections of an array photodetector to measure spectral intensity and thereby identify one or more compounds in the sample.

A multifocal spectrometric device is capable of simultaneously performing a measurement of a plurality of sample with high sensitivity, with no restriction on the magnification. A multifocal spectrometric device is a device in which beams of signal light emitted from a plurality of predetermined observation areas on samples placed in a sample placement section are introduced into a spectrograph and thereby dispersed into spectra, the device including: a plurality of objective lenses (objective light-condensing sections) individually located at positions which respectively and optically face the plurality of observation areas; and spectrograph input sections provided in such a manner that each of the plurality of objective lenses has one corresponding spectrograph input section, for introducing signal light passing through the corresponding objective lenses into the spectrograph. Since each objective lens only needs to observe one observation area, both the magnification and the numerical aperture can be simultaneously increased.

There is provided an optical measurement method using a detector having a detection sensitivity to at least a near-infrared region. The optical measurement method including: obtaining an output value by measuring a light sample at any exposure time with the detector; and correcting the output value with an amount of correction corresponding to the output value, when the exposure time at which the output value is obtained is within a second range. The amount of correction includes a product of a coefficient and a square of the exposure time, the coefficient indicating a degree to which an output value obtained when the light sample is measured with the detector at an exposure time within the second range deviates from output linearity obtained when the light sample is measured with the detector at an exposure time within a first range.

The disclosure provides a portable Raman device that includes a laser for emitting exciting light; a spectrometer for receiving Raman scattered light and converting the Raman scattered light into an electrical signal after beam splitting; a probe for leading the exciting light to irradiate on a sample and collect the Raman scattered light of the sample; and a fiber system connected between the laser and the probe as well as between the probe and the spectrometer so as to conduct light transmission. In comparison to conventional Raman devices, the portable Raman device of the disclosure has a simplified optical system, such that placement of components of the Raman device are more flexible, the whole size of the Raman device are reduced, and thus requirements of size miniaturization and quick real-time measurement are satisfied.