Devices and methods for container closure integrity testing by leak testing, in particular of pharmaceutical containers, which are composed of two parts, the container itself, which shows an opening, and a closure system that is used to close this opening of the container, such as a lid; and their application in quality control.

Method for leak testing a tank head, intended to be filled with a gas under high pressure and before it enters service, which head including at least two sealing devices, referred to as an inner and an outer sealing devices, which delimit there between an intermediate space into which opens a duct which communicates with the outside, such that: said test is carried out during the manufacture of the tank assembly, after fitting the tank head and before this tank is filled with high-pressure gas, pressurized gas is injected via the duct into the intermediate space between the two sealing devices, the gas injection is stopped at a given pressure, the value of said pressure is measured via said duct

There is provided a sensor including a housing, where the housing has an opening configured to receive a sensing element; an electric circuit operably connected to the housing, where the electric circuit is configured to detect at least one electrical characteristic across at least one pair of electrodes positioned on the sensing element; at least one gas-moving element in electrical communication with the electric circuit; and a reader in communication with the electric circuit, where the reader is configured to compare information about a gas volume external to the housing with information about a gas volume within the housing.

Exemplary embodiments disclosed herein are directed to systems and methods by which the level of liquid nitrogen in one or more liquid nitrogen storage containers can be monitored, leaks may be detected and reported, and ideal container fill level may be indicated.

A method for leak detection of a test specimen includes providing an evacuable film test chamber which is operatively coupled to a pressure measuring device, and at least one processor operatively coupled to the pressure measuring device; measuring a pressure within the evacuable film test chamber by the pressure measuring device at predetermined times during a measurement period of time; calculating by the processor, a first or higher order derivative of a pressure change with respect to time at a first predetermined time, and a first or higher order derivative of a pressure change with respect to time at least at a second predetermined time during the measurement period of time, to provide at least a pair of derivative values; and categorizing by the processor a leaky or tight state of the specimen under test by a pattern recognition process based on the pair of derivative values.

In one embodiment, systems and methods include using a pressure measurement and leak test tool to measure the internal pressure of a container. A pressure measurement and leak test tool comprises a first side, a second side, a top end, a bottom end, and a front surface. The first and second side are disposed along the same plane opposite from each other, wherein the top and bottom end are coupled to the first and second side, wherein the top and bottom end are disposed opposite from each other, wherein the front surface is disposed on an edge defined by the first side, the top end, the second side, and the bottom end. The pressure measurement and leak test tool further comprises an electrical connector disposed on the top end, a power switch disposed on the front surface, and an information handling system comprising a display disposed in the front surface.

There is provided a fit testing method comprising: providing a respirator donned by a wearer; providing a sensor in electrical communication with a sensing element, where the sensor is configured to monitor a particulate concentration parameter of a gas space within the respirator, and a second particulate concentration parameter of a gas space outside the respirator, where the sensor is attached to the respirator such that the respirator such that the weight of the sensor is supported by the respirator; and providing a reader configured to communicate with the sensor, where the reader is configured to provide a respirator fit parameter based on a comparison of the particulate concentration within the respirator to the particulate concentration parameter outside the respirator.

Methods, apparatus, systems and articles of manufacture are disclosed for leak detection from a thief hatch. An example thief hatch includes a vent control stem coupled to first and second sealing plates, the first and second sealing plates to control fluid flow through the thief hatch based on translation of the vent control stem, and an indicator extending from the vent control stem to provide a visual indication of a condition of the fluid flow.

A leakage inspection method and leakage inspection device for container to be inspected are provided. When a container to be inspected having a deformable flexible part is to be inspected for leakage, the container to be inspected is filled with an inspection gas containing helium, the container to be inspected, which has been filled with the inspection gas, is disposed in an inspection chamber partitioned from the outside, and an upward flow of a carrier gas is formed from the lower part to the upper part of the container to be inspected. A leakage of the inspection gas filled in the container to be inspected is then detected on the basis of the result of measuring the concentration of helium in the carrier gas collected at a position higher than a position where the carrier gas is fed into the inspection chamber.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs).