Disclosed herein, inter alia, are devices and methods for transfer and analyses of tissue sections using carrier substrates.

Embodiments of the invention are generally directed to analyte detection and products facilitating the collection, separation of sample components, and analyte detection. The multilayer device that allows for a rapid, easy, accurate, and efficient test of a fluid sample for analytes of interest and methods of collecting, separating components, and testing using the multilayer device are described in various embodiments of the invention.

Disclosed herein, inter alia, are devices and methods for efficient transfer and analyses of cellular material, tissue samples, such as tissue sections, using carrier substrates and devices.

Disclosed herein, inter alia, are devices and methods for transfer and analysis of tissue sections using carrier substrates.

Disclosed herein, inter alia, are methods for the transfer and manipulation of tissue sections using hydrogel substrates.

A micro well plate is described for capturing and distributing single cells in individual wells is described, wherein at least one individual well is provided with a bottom plate having at least one pore to pass sample liquid, such that if one object or cell of interest is collected on the bottom plate of the well, the sample flow rate through that particular well is significantly reduced, minimizing the possibility that multiple cells or objects of interest entering the same well. The presented invention is particularly suited for obtaining single cells and/or microorganisms suspended in fluid samples for subsequent detailed interrogation.

Embodiments of the invention are generally directed to analyte detection and products facilitating the collection, separation of sample components, and analyte detection. The multilayer device that allows for a rapid, easy, accurate, and efficient test of a fluid sample for analytes of interest and methods of collecting, separating components, and testing using the multilayer device are described in various embodiments of the invention.

The present invention is related to a cutting system. It is further related to a system for obtaining a sample of plant material and method. Such a system can for instance be used for DNA analysis as part of a plant breeding program. According to the invention, the cutting system comprises a cutting device having a hollow cutting element having a cutting edge facing a leaf of a plant to be sampled, a drive unit for rotating said cutting element about a longitudinal axis of said cutting element to cut through the leaf, and a gas flow direction unit for applying a suction force through the hollow cutting element. The cutting system further comprises a control unit for controlling the drive unit and the gas flow direction unit. According to the invention, the hollow cutting element is elongated and the control unit is configured to control the gas flow direction unit and the drive unit such that said suction force is applied during said cutting through the leaf, and preferably at least prior to said cutting through the leaf.

Specimen collection slides, methods of fabricating and methods of utilizing such specimen collection slides whereby each specimen collection slide includes a top rigid layer with an opening, a bottom rigid layer with an opening substantially the same size as the top layer opening, a middle rigid section having an opening larger than the openings in both the top and bottom layers, and a filtration media residing within the opening in the middle section. The top, bottom and middle are secured together to provide the resultant slide with thickness and rigidity that lends the slide to be utilized in automated handling processes and instruments. The middle section of the slide encases the filtration media and sandwiches it between the top and bottom layers so that the filtration media is protected from damage. Each slide may have its own unique identifier.

Disclosed herein, inter alia, are devices and methods for transfer and analysis of tissue sections using carrier substrates.