The resorbable preparation for medical use, and in particular for use as an resorbable dressing for difficult wounds, includes an amorphous hydrogel composed primarily of a mixture of animal collagen, glycerol, xylitol and ozonized vegetable oil in water.

The mixture may include, depending on the applications and methods of preparation: water, in proportion in the range of 10% to 90% by weight; either animal or synthetic collagen, in proportion in the range of 40% to 70% by weight; glycerol, in proportion in the range of 20% to 50% by weight; xylitol, in proportion in the range of 0.05% to 5% by weight; ozonized vegetable oil, in a proportion ranging between 0.001% and 10% by weight; lactoferrin, in proportion in the range of 0.001% to 10% by weight;

The proportion of water is defined as a function of the desired consistency for the resorbable preparation.

A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound.

A substrate based skin contact material formed from a hydrocolloid having a silicone based component extending over regions of the substrate surface. The adhesive is formed non-continuously over the substrate to provide areas devoid of adhesive to allow appreciable moisture transfer between the skin and substrate and improve the skin friendliness of the material during use and allow convenient removal with avoidance of skin irritation.

The present invention relates to a packaged probiotic composition which is useful for treating or preventing bacterial colonisation in wounds and tissue. A characteristic feature of the invention is that the probiotic composition contains a probiotic microorganism which is in direct contact with water during storage of the probiotic composition. The invention furthermore pertains to methods of using and producing the probiotic composition.

A device for sealing and securing a catheter at its insertion site in order to provide for optimum safe catheter function, and to achieve maximum catheter longevity/dwell time is described. The sterile seal achieved by this device fully protects the catheter and its insertion site from external contamination. The unique sterile seal also functions to fully stabilize and secure the catheter, thereby minimizing traumatic catheter injury and loss. A means of continuously viewing the insertion site is also provided, as well as mechanisms for maintaining sterility of the sterile chamber that is formed around the catheter insertion site by the integrated sealing and securing device. Together these features allow for improved catheter safety and function, and allow catheters to safely remain in place for an extended period of time. The need to change catheter dressings at intervals is minimized or eliminated.

The present invention is directed to an absorbable hemostatic patch that utilizes a biocompatible fibrous, fabric substrate that is melt-blown and napped or loosened at the surface, with the substrate having a low-profile, high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ultimately effective for use as a hemostat in situations of problematic bleeding.

Methods and products for protecting tissue of a patient during a surgical procedure that involve making an incision in the tissue and retracting the tissue to make a larger opening, wherein the methods and products use a water-absorbing stress-distributing layer.

The present disclosure concerns a wound monitoring system for monitoring a bacterial 5 infection at a wound site, comprising a biosensing module that is contactable with the wound site, the biosensing module being configured to output a signal indicative of presence of at least one biomolecule released by bacterial cells at the wound site, and a readout circuitry coupled to the biosensing module for wirelessly transmitting the signal to an external device. The signal is a change in dielectric permittivity of the biosensing module. The present disclosure concerns a method of fabricating the wound monitoring system and a method of monitoring a bacterial infection at the wound.

Methods and compositions for securing to and removing adhesive tapes from substrates, e.g., delicate substrates such as skin, are described. The methods include providing an adhesive tape comprising an adhesive layer and a support layer in contact with the adhesive layer. A first adhesion level between the adhesive layer and the support layer is, or can be controlled to be, less than a second adhesion level between the adhesive layer and the substrate. The methods further include applying the adhesive tape to the substrate by contacting the adhesive layer to the substrate while the support layer remains in contact with the adhesive layer; and removing the support layer from the substrate by separating the support layer from the adhesive layer.

A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound.