Methods of analyzing and filtering light scattering data from a sample potentially containing a non-target compound, for example a contaminant. The presence of contaminants result in outliers in the scattering intensity data that increase both symmetry and width of photon counts obtained via analysis. After identification, various outliers are discarded to account for the non-target compounds and thereafter the remaining light scattering data is analyzed. Preferably, analyzing the light scattering data or photon counts involves determining a level to discard an outlier. In particular, the method includes the steps of identifying and quantifying the mode of photon count distribution and using the peak of the mode of distribution to eliminate outliers.

An apparatus for particle characterisation, comprising: a sample cell for holding a sample; a light source configured to illuminate the sample with an illuminating beam and a plurality of light detectors, each light detector configured to receive scattered light resulting from the interaction between the illuminating beam and the sample along a respective detector path, wherein each respective detector path is at substantially the same angle to the illuminating beam.

Method of characterizing particles suspended in a fluid dispersant by light diffraction, comprising: obtaining measurement data from a detector element, the detector element being arranged to measure the intensity of scattered light; identifying a measurement contribution arising from light scattered by inhomogeneities in the dispersant; processing the measurement data to remove or separate the measurement contribution arising from light scattered by inhomogeneities in the dispersant; calculating a particle size distribution from the processed measurement. The detector element is one of a plurality of detector elements from which the measurement data is obtained. The detector elements are arranged to measure the intensity of scattered light at a plurality of scattering angles, the plurality of scattering angles distributed over a plurality of angles about an illumination axis. Identifying a measurement contribution arising from light scattered by inhomogeneities in the dispersant comprises identifying measured scattered light that is asymmetric about the illumination axis.

A method for inspecting a lubricant oil composition containing a base oil and a fullerene, the method including: measuring at least one of a lamellar length of the lubricating oil composition and a most abundant diameter in a particle size distribution obtained by a dynamic light scattering method, and selecting the lubricating oil composition whose measured value is within a set range.

An apparatus for particle characterisation, comprising: a sample cell for holding a sample; a light source configured to illuminate the sample with an illuminating beam and a plurality of light detectors, each light detector configured to receive scattered light resulting from the interaction between the illuminating beam and the sample along a respective detector path, wherein each respective detector path is at substantially the same angle to the illuminating beam.

Systems and methods for holographic characterization of protein aggregates. Size and refractive index of individual aggregates in a solution can be determined. Information regarding morphology and porosity can be extracted from holographic data.

The present invention relates to a method for measuring characteristics of particles in solution and to a device for performing the same, wherein said method comprises the steps of providing a vessel comprising a sample of said particles in solution, wherein the sample has preferably a volume between 0.1 μL and 15 μL, providing a monochromatic light source and a light detector, transmitting light from the monochromatic light source to the vessel comprising the sample, detecting light emitted from the vessel with the light detector, and determining characteristics of said particles in solution comprised in the sample based on a dynamic light scattering (DLS) measurement.

An image pickup apparatus includes a signal acquisition unit and a rotation unit. The signal acquisition unit includes an illumination unit including a light source and configured to irradiate a sample with a light beam, a photodetector including a plurality of light-receiving portions two-dimensionally arranged, and a detection optical system configured to guide light having been irradiated from the illumination unit to the sample and passed through the sample, to the photodetector. The rotation unit rotates the sample and the signal acquisition unit relative to each other, about a first axis intersecting an optical axis of the detection optical system in the sample. The illumination unit irradiates the sample with light beams at two or more incident angles in a plane including the optical axis and the first axis.

Provided are a dynamic light scattering measurement method and a dynamic light scattering measurement device with which a particle size distribution of each type of particle included in a dispersion liquid including particles is obtained. A dynamic light scattering measurement method for a dispersion liquid including a plurality of types of particles includes a measurement step of measuring a scattering intensity of the dispersion liquid a plurality of times to obtain a plurality of pieces of scattering intensity data while changing a value of any one of at least a scattering angle or a measurement wavelength among measurement parameters, a calculation step of calculating a plurality of pieces of scattering intensity time variation characteristic data and a plurality of scattering intensity parameter-dependent data from the plurality of pieces of scattering intensity data obtained by the measurement step, and a step of obtaining a particle size distribution of each type of particle of a plurality of types of particles by fitting the plurality of pieces of scattering intensity time variation characteristic data and the plurality of pieces of scattering intensity parameter-dependent data, which are obtained by the calculation step, with respect to a theoretical formula that defines a relationship between a particle diameter and the scattering intensity.

Systems and methods for holographic characterization of protein aggregates. Size and refractive index of individual aggregates in a solution can be determined. Information regarding morphology and porosity can be extracted from holographic data.