An irradiation unit configured to scan and irradiate a sample with pulse waves; a reception unit configured to receive reflected waves of the pulse waves from the sample; a waveform generation unit configured to generate time waveforms of a signal representing the reflected waves at respective scan positions of the pulse waves; and a waveform correction unit configured to detect at least one peak in each of the time waveforms, and correct each of the time waveforms on a basis of each of positions of the at least one peak in the time waveforms are included.

A method for determining properties of a laboratory sample contained in a laboratory sample container is presented. The method comprises measuring projections of the laboratory sample container comprising the laboratory sample by irradiating light to the laboratory sample container at different projection angle and determining the properties by tomographic reconstruction based on the projections.

The invention provides an Optical Coherence Tomography (OCT) system capable of acquiring two orthogonally polarized depth scans from a target such as the fingerprint region of a finger. In the preferred embodiment the birefringence of tissue components and, optionally, other aspects of the target are measured in order determine a characteristic of the target, such as whether it is real of fake finger.

Apparatuses and methods for implementing scanning trajectories for ROI tomography are disclosed herein. An example method includes determining a first focus object distance based on a circumradius of a sample, the sample including a region of interest, determining a second focus object distance based on a radius of a smallest cylinder that contains the region of interest, determining a plurality of viewing angles from a plurality of possible viewing angles in response to the first focus object distance, where each viewing angle of the plurality of viewing angles has an associated focus object distance measured from the region of interest, and where the associated focus object distance of each of the plurality of viewing angles is less than the first focus object distance and greater than the second focus object distance, and scanning the region of interest using at least the plurality of viewing angles.

Disclosed herein are optical integration technologies, designs, systems and methods directed toward Optical Coherence Tomography (OCT) and other interferometric optical sensor, ranging, and imaging systems wherein such systems, methods and structures employ tunable optical sources, coherent detection and other structures on a single or multichip monolithic integration. In contrast to contemporary, prior-art OCT systems and structures that employ simple, miniature optical bench technology using small optical components positioned on a substrate, systems and methods according to the present disclosure employ one or more photonic integrated circuits (PICs), use swept-source techniques, and employ a widely tunable optical source(s).

In another embodiment the system uses an optical photonic phased array. The phase array can be a static phased array to eliminate or augment the lens that couples light to and from a sample of interest or can be static and use a spectrally dispersive antenna and a tunable source to perform angular sweeping. The phased array can be active in 1 or 2 dimensions so as to scan the light beam in angle. The phased array can also adjust focus. The phased array can implement an optical waveform that will extend depth of field focus for imaging. The phase array can also be a separate standalone element that is fed by one or more optical fibers. The phased array can be for scanning a biomedical specimen used in conjunction with a swept-source OCT system, can be used in a free-space coherent optical communication system for beam pointing or tracking, used in LIDAR applications, or many other beam control or beam steering applications.

Disclosed herein are optical integration technologies, designs, systems and methods directed toward Optical Coherence Tomography (OCT) and other interferometric optical sensor, ranging, and imaging systems wherein such systems, methods and structures employ tunable optical sources, coherent detection and other structures on a single or multichip monolithic integration. In contrast to contemporary, prior-art OCT systems and structures that employ simple, miniature optical bench technology using small optical components positioned on a substrate, systems and methods according to the present disclosure employ one or more photonic integrated circuits (PICs), use swept-source techniques, and employ a widely tunable optical source(s).

In another embodiment the system uses an optical photonic phased array. The phase array can be a static phased array to eliminate or augment the lens that couples light to and from a sample of interest or can be static and use a spectrally dispersive antenna and a tunable source to perform angular sweeping. The phased array can be active in 1 or 2 dimensions so as to scan the light beam in angle. The phased array can also adjust focus. The phased array can implement an optical waveform that will extend depth of field focus for imaging. The phase array can also be a separate standalone element that is fed by one or more optical fibers. The phased array can be for scanning a biomedical specimen used in conjunction with a swept-source OCT system, can be used in a free-space coherent optical communication system for beam pointing or tracking, used in LIDAR applications, or many other beam control or beam steering applications

The present invention provides a method for evaluating a protrusion-forming ability of cell spheroids, comprising step (a) of imaging a cell spheroid labeled with a fluorescent substance using a fluorescence microscope at a resolution capable of identifying individual cells, and acquiring a plane tomographic image of a fluorescence emitted from the fluorescent substance, step (b) of analyzing the plane tomographic image acquired in step (a) to determine a protrusion part of the cell spheroid, and step (c) of evaluating a protrusion-forming ability of the cell spheroid based on the protrusion part determined in step (b).

A method and system for rapid, label free nanoscale chemical imaging and tomography (3D) with multiplexing for speed, and engineered coherent illumination and detection to achieve 3-D resolution at twice the Abbe limit. A sample undergoes photo-thermal heating using a modulated infrared light source and the resulting probe beam modulation is measured with one or more visible laser probes. Varying the infrared wavelength results in a spectrum which characterizes the chemical composition of the sample. Optionally, inelastically scattered light generated as a result of the probe beam interacting with the sample is collected simultaneously to yield additional chemical information.

An optical-fiber measurement system includes an optical system that generates light and a spatial optical switch that is coupled to the optical system that processes the light generated by the optical system and generates light at a plurality of spatially distributed optical ports. A respective one of a plurality of optical cores at a first end of a multicore optical fiber is positioned to receive light from a respective one of the plurality of spatially distributed optical ports, where the light generated at the plurality of spatially distributed optical ports propagates through the multicore optical fiber. Distal optics is positioned adjacent to a second end of the multicore optical fiber and is positioned to collect light from a sample of interest so that the collected light from the sample of interest is coupled to the plurality of optical cores in the multicore optical fiber.

A method for pre-positioning a coaxial sample and sheath combination includes calculating a load shape profile including a plurality of layers of substantially equal volume. The calculated load shape profile is incrementally divided into cross-sectional slices at a first set of distance coordinates along a first axis. Each cross-sectional slice transects the plurality of layers. A sample includes a number of objects residing in solution. A sample chamber is loaded with the sample by incrementally dispensing the sample in a plurality of portions along a vertical axis divided into a second set of distance coordinates proportional to the first set of distance coordinates, where each portion has a volume proportional to the cross-sectional slice at the first distance coordinate nearest in value to the second distance coordinate.