Disclosed is a method for classifying monitoring results from an analytical sensor system (20) arranged to monitor molecular interactions at a sensing surface, wherein detection curves representing progress of the molecular interactions with time are produced. The method comprises steps of: acquiring (100) a set of detection curves, fitting (101) a first mathemati- cal model to the set of detection curves; calculating (102) a set of features from the set of detection curves and fitted mathematical model; based on the calculated set of features, classifying (103) each detection curve into qual- ity classification group; and based on the classification determining which detection curves to use in kinetic analysis of the monitored molecular inter- actions.

Embodiments of the present disclosure provide for methods of detecting, sensors (e.g., chromogenic sensor), kits, compositions, and the like that related to or use tunable macroporous polymer. In an aspect, tunable macroporous materials as described herein can be used to determine the presence of a certain type(s) and quantity of liquid in a liquid mixture.

This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed biological samples. The subject methods include generating a reaction product by carrying out a biochemical reaction on the biological sample introduced into a device and reacting the reaction product with an indicator capable of generating a detectable change in an optical property of the biological sample to indicate the presence, absence, or amount of analyte suspected to be present in the sample.

Disclosed herein are systems and methods for quantifying analytes in a desired complex solution with minimal inter-sample variability. The invention includes methods and diagnostic tools for quantifying analytes in aqueous solutions or biological fluid samples with sample-specific calibration and colorimetric or detectable output.

The invention concerns a method, an assembly and a system for determining a characteristic property of a molecular interaction. The method includes providing a liquid sample including a particle capable of being in a state of equilibrium and in a state of non-equilibrium. The particle includes a marker in at least one of its state of equilibrium and state of non-equilibrium. The method further includes bringing the particle in a state of non-equilibrium by subjecting the sample to a condition jump comprising a jump in temperature and/or pressure; reading out the marker as a function of time during at least a portion of a relaxation time for said particle, and determining said characteristic property of said molecular interaction.

In an embodiment, an optical system comprises an optical cell having an interior fluid chamber defined by an interior surface of a housing, a process inlet disposed in the housing and in fluid communication with the interior fluid chamber, and a process outlet disposed in the housing and in fluid communication with the interior fluid chamber, wherein the process inlet and process outlet facilitate the flow of a fluid through the interior fluid chamber. A sampling outlet can be disposed in the housing and in fluid communication with the interior fluid chamber. A first bi-directional pump can be in fluid communication with the sampling outlet and a first storage vessel and can be configured to withdraw a first sample of the fluid via the sampling outlet and to cause the first sample to flow into the first storage vessel.

A method to make it possible to obtain a value related to the amount of DD by FDP measurement. The method includes optically measuring a first calibration sample prepared from an FDP measurement reagent and a first calibrator containing D-dimer (DD) and having a first value relating to the ratio of the content of fibrin/fibrinogen degradation product FDP to the content of DD, acquiring first calculation data based on temporal change of optical information obtained by optical measurement of the first calibration measurement sample, performing optical measurement of a second calibration measurement sample prepared from FDP measurement reagent and a second calibrator containing DD and having a second value that is different from the first value related to the ratio of the content of FDP to the content of DD, acquiring second calculated data based on a temporal change in optical information obtained by optical measurement of the second calibration measurement sample, and acquiring calibration curve information indicating the relationship between the calculation data and the value relating to the amount of DD based on the first calculation data, the second calculation data, the first value, and the second value.

A luminometer (400) includes a light detector (630) configured to sense photons (135). The luminometer (400) includes an analog circuit (915a) configured to provide an analog signal (965) based on the photons (135) emitted from assay reactions over a time period and a counter circuit (915b) configured to provide a photon count (970) based on the photons (135) emitted from the assay reactions over the time period. The luminometer (400) includes a luminometer controller (905) configured to, in response to an analog signal value of the analog signal (965) being greater than a predetermined value, determine and report a measurement value of the photons (135) emitted from the assay reactions over the time period based on the analog signal value of the analog signal (965) and a linear function (1010). Optionally, the linear function (1010) is derived from a relationship between the analog signal (965) and the photon count (970).

The present invention relates to a method for acquiring information on a cause of prolongation of coagulation time. The present invention also relates to a device, a system and a computer program for analyzing blood coagulation.

An apparatus and method for measuring hydrogen peroxide concentration in water to an accuracy of 0.1 ppm comprises a colorimetric assay method to determine hydrogen peroxide concentration. The assay is monitored spectophotometrically at a desired wavelength. Each sample is corrected relative to a control sample and hydrogen peroxide concentration determined with respect to a standard curve.