Disclosed is a detection method for detecting occurrence of nonspecific reaction in analysis for an antigen or an antibody contained in a biological sample with use of a measurement reagent containing an antibody or an antigen that causes antigen-antibody reaction with the antigen or the antibody in the biological sample, and the detection method includes: generating a data group about progress of antigen-antibody reaction between the antigen or the antibody contained in the biological sample and the antibody or the antigen contained in the measurement reagent; inputting the data group to a deep learning algorithm; and generating information about occurrence of nonspecific reaction, based on a result outputted by the deep learning algorithm.

Provided herein are processes for preparing fluorescent 1-cyano-2-substituted isoindole compounds or N-substituted phthalazinium compounds, comprising reacting an aromatic dialdehyde or aromatic aldehyde-ketone compound with a material that contains primary amino or hydrazine groups, and assaying methods involving the processes thereof.

A breath analyte capture device includes a breath input port into which a user exhales a breath sample, and a cartridge insertion port for receiving a disposable cartridge containing an interactant. During exhalation of a breath sample, at least a portion of the breath sample is routed through the cartridge such that the analyte (such as breath acetone) is captured by the interactant. In some embodiments, the concentration of the analyte in the breath sample is measured by monitoring a chemical reaction that occurs in the disposable cartridge. The chemical reaction may be monitored by illuminating the cartridge at each of multiple light wavelengths while measuring reflected light.

A device for measuring oxygen saturation includes circuitry configured to determine a series resistance for a light emitting diode based on a first diode voltage at the light emitting diode for a first current, a second diode voltage at the light emitting diode for a second current, and a third diode voltage at the light emitting diode for a third current. The circuitry is further configured to determine an intensity of a received photonic signal corresponding to an output photonic signal output using the light emitting diode. The circuitry is further configured to determine an oxygen saturation level based on the intensity of the received photonic signal and the series resistance.

An optical system configured to measure a raised or receded surface feature on a surface of a sample may comprise a broadband light source; a tunable filter configured to filter broadband light emitted from the broadband light source and to generate a first light beam at a selected wavelength; a linewidth control element configured to receive the first light beam and to generate a second light beam having a predefined linewidth and a predetermined coherence length; collimating optics optically coupled to the second light beam and configured to collimate the second light beam; collinearizing optics optically coupled to the collimating optics and configured to align the collimated second light beam onto the raised or receded surface feature of the sample, and a processor system and at least one digital imager configured to measure a height of the raised surface or depth of the receded surface from light reflected at least from those surfaces.

An electronic device includes at least one grid structure that extends in rows and columns of a pixel array including a plurality of imaging pixels and is structured to separate the imaging pixels from one another to provide optical isolation between two adjacent imaging pixels, a grid shutter coupled to the grid structure and configured to allow a gas to enter the grid structure by opening a passage for the gas or block the gas from entering the grid structure by closing the passage in the grid structure, and a gas detection controller configured to identify the gas flowing into the grid structure based on an image that is acquired by the image sensor when the passage for the gas in the grid structure is opened to allow the gas to be present in the grid structure.

An apparatus for estimating bio-information includes an optical sensor including a light source configured to emit light of multiple wavelengths onto an object, and including a plurality of detectors configured to detect light of each wavelength which is scattered or reflected from the object. The apparatus includes a processor configured to obtain spectra based on light of each wavelength which is detected by each detector, determine valid spectra of the obtained spectra, and estimate a bio-information value based on the valid spectra.

According to one embodiment, there is provided a measuring apparatus including a measurement section and a control section. The measurement section is configured to acquire a response from a sample. The control section is configured to compare a loading obtained by performing principal component analysis in advance with a first evaluation-use loading obtained by performing principal component analysis onto the response acquired from the sample, and to generate a first reliability index for measurement using principal component analysis, in accordance with a comparison result.

An apparatus includes an integrated sensor module for detection of chemical substances. The sensor module includes a UV radiation source operable to emit UV radiation onto a sample. The sensor module also includes a sensor including dedicated channels disposed so as receive UV radiation reflected by the sample. Each of the channels is selectively sensitive to a different respective portion of the UV spectrum; collectively, the channels cover at least part of the UV spectrum sufficient for reconstruction of a spectral curve of the sample. An electronic control unit can be used to identify a composition of the sample based on signals from the channels.

The present invention is directed to an apparatus (10) for reliable quantitative measurement of a fluorescent blood analyte in tissue (12) comprising: at least one light source (14), the light source (14) emitting excitation light at least at a first wavelength range between 350 nm and 450 nm to the tissue (12); a detection unit (16), the detection unit (16) measuring: a) a portion of the fluorescent light emitted by the fluorescent blood analyte excited at the first wavelength range; and b) a portion of the auto fluorescence emitted by the tissue (12); and/or c1) a portion of the remitted excitation light at the first wavelength range, and c2) a portion of the remitted light at a second wavelength range; and a control unit (18), the control unit (18) operating the light source (14) and detection unit (16). The present invention is further directed to a method for quantitative measurement of a fluorescent blood analyte in tissue (12).